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6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE

6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE ??? ???
?? ??:
452-35-7
???:
6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE
???(??):
ETHOXZOLAMIDE;U-4191;Cardrase;Ethamide;mingoral;L-643786;PNU-4191;diureticc;Diuretic C;Redupresin
CBNumber:
CB4401490
???:
C9H10N2O3S2
??? ??:
258.32
MOL ??:
452-35-7.mol

6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE ??

???
190-193 °C(lit.)
?? ?
464.9±37.0 °C(Predicted)
??
1.4767 (rough estimate)
???
1.6800 (estimate)
?? ??
Refrigerator
???
DMSO(?? ???), ???????(?? ???)
?? ?? (pKa)
pKa 8.12(H2O t=25.0) (Uncertain)
??? ??
??
??? ??
??? ??
??
???
???
10.33mg/L(25℃)
Merck
13,3790
InChI
InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
InChIKey
OUZWUKMCLIBBOG-UHFFFAOYSA-N
SMILES
S1C2=CC(OCC)=CC=C2N=C1S(N)(=O)=O
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 26
WGK ?? 3
RTECS ?? DL6390000
???? ??? 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
?? ?? ??? 452-35-7(Hazardous Substances Data)
????(GHS): Exclamation Mark (GHS07)
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE C??? ??, ??, ??

??

alcohol dehydrogenase inhibitor, antidote

??

ChEBI: 1,3-Benzothiazole substituted a sulfonamide and an ethoxy group at positions 2 and 6, respectively. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic.

?? ??

6-Ethoxy-2-benzothiazolesulfonamide is a membrane permeable carbonic anhydrase inhibitor and its ocular disposition and pharmacology in normal albino rabbits has been investigated. It causes inhibition of insulin degradation in vitro.

Clinical Use

Ethoxzolamide is another carbonic anhydrase inhibitor with properties and uses resembling those of acetazolamide.

6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE ?? ?? ? ???

???

?? ??


6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE ?? ??

???( 97)?? ??
??? ?? ??? ?? ?? ? ??
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6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE ?? ??:

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