Dicloxacillin sodium
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Dicloxacillin sodium ??
- ???
- 222-225°C
- ??
- D20 +127.2° (water)
- ?? ??
- 2-8°C
- ???
- H2O: ???50mg/mL
- ??? ??
- ??
- ??
- ???? ?????
- ???
- ?? ???
- BRN
- 4778711
- ???
- ???
- ?? ??
- clinical testing
- InChIKey
- SIGZQNJITOWQEF-VICXVTCVSA-M
- SMILES
- [Na+].[H]O[H].Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C([O-])=O)-c4c(Cl)cccc4Cl
- CAS ??????
- 13412-64-1(CAS DataBase Reference)
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- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 36/37/38-42/43 | ||
| ????? | 22-26-36/37-45 | ||
| WGK ?? | 2 | ||
| RTECS ?? | XH8925000 | ||
| HS ?? | 29411099 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Eye Irrit. 2 Resp. Sens. 1 Skin Irrit. 2 STOT SE 3 |
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| ?? | LD50 in mice (g/kg): 0.9 i.v.; in rats (g/kg): 0.63 i.p.; >5 orally (Gloxhuber) |
Dicloxacillin sodium C??? ??, ??, ??
??? ??
White to off-white crystalline powder??
Dicloxacillin sodium salt is used in the treatment of staphylococci resistant to penicillin G. Dicloxacillin binds to specific penicillin-binding proteins in the bacterial cell wall and therefore inhibits the last stage of bacterial cell wall synthesis. Cell lysis, mediated by bacterial cell wall autolytic enzymes, is the result. Dicloxacillin may interfere with autolysin inhibitors.?? ??
The substitution of chlorine atoms on both carbons orthoto the position of attachment of the phenyl ring to the isoxazolering is presumed to enhance further the stability ofthe oxacillin congener dicloxacillin sodium, [3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]penicillin sodiummonohydrate (Dynapen, Pathocil, Veracillin) and toproduce high plasma concentrations of it. Its medicinalproperties and use are similar to those of cloxacillinsodium. Progressive halogen substitution, however, alsoincreases the fraction bound to protein in the plasma, potentiallyreducing the concentration of free antibiotic inplasma and tissues. Its medicinal properties and use are thesame as those of cloxacillin sodium.Dicloxacillin sodium ?? ?? ? ???
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?? 2-????????
Dicloxacillin
3-(2,6-??????)-5-??????-4-?????????
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6-??????? ?
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Dicloxacillin sodium ?? ??
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