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- 180-182°C
- ?? ?
- 599.6±60.0 °C(Predicted)
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- 1.23±0.1 g/cm3(Predicted)
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- 2-8°C
- ???
- DMSO: ~11mg/mL( 60 °C)
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- ?? ?? (pKa)
- pKa 6.5 (Uncertain)
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- CAS ??????
- 83366-66-9(CAS DataBase Reference)
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| ????? | 22-24/25 | ||
|---|---|---|---|
| WGK ?? | 3 | ||
| ?? ?? ??? | 83366-66-9(Hazardous Substances Data) |
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Crystalline Solid??
A selective serotonin 5-HT2 receptor antagonist. An antidepressantBiological Functions
Although nefazodone (Serzone) is structurally related to trazodone, it is less sedating. It does not block α1- adrenoreceptors, and its use is not associated with priapism. Nefazodone inhibits the neuronal reuptake of serotonin and blocks 5HT2A receptors. Its short half-life requires dosing twice a day. Nefazodone is not associated with weight gain or sexual dysfunction. It inhibits the cytochrome P450 3A4 isoenzyme that is responsible for 50% of known oxidative metabolism, and therefore, nefazodone can elevate levels of drugs dependent on this pathway for metabolism.???? ?? ?? ? ???
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3-???-5-???-1,2,4-????
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1-???-3-???????
3-?????????
Α-PHENOXYPROPIONIC ACID
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