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ChemicalBook >> CAS DataBase List >>Nefazodone

Nefazodone

CAS No.
83366-66-9
Chemical Name:
Nefazodone
Synonyms
SERZONE;Dutonin;Nefadar;BMY-13754;NEFAZODONE;MJ-13754-1;MJ-13754-I;Nefazodone base;l)-5-ethyl-4-(2-phenoxyethyl)-;Nefazodone (base and/or unspecified salts)
CBNumber:
CB5144862
Molecular Formula:
C25H32ClN5O2
Molecular Weight:
470.01
MDL Number:
MFCD00865396
MOL File:
83366-66-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 15:13:49
Product description Number Pack Size Price
2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one AA00ID7W 2mg $48
2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one ≥98% AA00ID7W 5mg $52
2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one ≥98% AA00ID7W 10mg $82
2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one AA00ID7W 25mg $166
2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one AA00ID7W 50mg $247
More product size

Nefazodone Properties

Melting point 180-182°C
Boiling point 599.6±60.0 °C(Predicted)
Density 1.23±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ~11 mg/mL at 60 °C
form solid
pka pKa 6.5 (Uncertain)
color white
CAS DataBase Reference 83366-66-9(CAS DataBase Reference)
NCI Dictionary of Cancer Terms nefazodone; Serzone
FDA UNII 59H4FCV1TF
ATC code N06AX06
NIST Chemistry Reference Nefazodone(83366-66-9)

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3
Hazardous Substances Data 83366-66-9(Hazardous Substances Data)

Nefazodone price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
aablocks AA00ID7W 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one 83366-66-9 2mg $48 2026-05-29 Buy
aablocks AA00ID7W 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one ≥98% 83366-66-9 5mg $52 2026-05-29 Buy
aablocks AA00ID7W 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one ≥98% 83366-66-9 10mg $82 2026-05-29 Buy
aablocks AA00ID7W 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one 83366-66-9 25mg $166 2026-05-29 Buy
aablocks AA00ID7W 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one 83366-66-9 50mg $247 2026-05-29 Buy
Product number Packaging Price Buy
AA00ID7W 2mg $48 Buy
AA00ID7W 5mg $52 Buy
AA00ID7W 10mg $82 Buy
AA00ID7W 25mg $166 Buy
AA00ID7W 50mg $247 Buy

Nefazodone Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Originator

Dutonin,Bristol-Myers Squibb,USA

Uses

A selective serotonin 5-HT2 receptor antagonist. An antidepressant

Definition

ChEBI: Nefazodone is a N-arylpiperazine, a N-alkylpiperazine, a member of triazoles, a member of monochlorobenzenes and an aromatic ether. It has a role as an antidepressant, a serotonergic antagonist, a serotonin uptake inhibitor, an alpha-adrenergic antagonist and an analgesic.

brand name

Serzone (Bristol-Myers Squibb).

Therapeutic Function

Antidepressant

Biological Functions

Although nefazodone (Serzone) is structurally related to trazodone, it is less sedating. It does not block α1- adrenoreceptors, and its use is not associated with priapism. Nefazodone inhibits the neuronal reuptake of serotonin and blocks 5HT2A receptors. Its short half-life requires dosing twice a day. Nefazodone is not associated with weight gain or sexual dysfunction. It inhibits the cytochrome P450 3A4 isoenzyme that is responsible for 50% of known oxidative metabolism, and therefore, nefazodone can elevate levels of drugs dependent on this pathway for metabolism.

Global( 69)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49979 58
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418684 +8618949823763 sales@tnjchem.com China 25356 58
Shaanxi Didu New Materials Co. Ltd
+8617792793228 1069@dideu.com China 8561 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
+1-781-999-5354; support@targetmol.com United States 39039 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580 cooperation@kean-chem.com China 40066 58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.
+8618950047208 ellena@amitychem.com China 43414 58

View Lastest Price from Nefazodone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nefazodone pictures 2026-05-26 Nefazodone
83366-66-9
$35.00-54.00 99.85% 10g TargetMol Chemicals Inc.
Nefazodone pictures 2019-07-06 Nefazodone
83366-66-9
$1.00 1G 98% 100KG Career Henan Chemical Co
  • Nefazodone pictures
  • Nefazodone
    83366-66-9
  • $35.00-54.00
  • 99.85%
  • TargetMol Chemicals Inc.
  • Nefazodone pictures
  • Nefazodone
    83366-66-9
  • $1.00
  • 98%
  • Career Henan Chemical Co

Nefazodone Spectrum

3h-1,2,4-triazol-3-one,2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propy l)-5-ethyl-4-(2-phenoxyethyl)- BMY-13754 SERZONE MJ-13754-1 NEFAZODONE 2-[3-[4-(3-CHLOROPHENYL)-1-PIPERAZINYL]PROPYL]-5-ETHYL-2,4-DIHYDRO-4-(2-PHENOXYETHYL)-3H-1,2,4-TRIAZOL-3-ONE HYDROCHLORIDE Nefazodone base 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one, Hydrochloride 3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)- Nefazodone (base and/or unspecified salts) Dutonin MJ-13754-I 2-[3-[4-(3-Chlorophenyl)piperazino]propyl]-4-(2-phenoxyethyl)-5-ethyl-2H-1,2,4-triazole-3(4H)-one 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one Nefadar 83366-66-9 C25H32ClN5O2 API Intermediates & Fine Chemicals Pharmaceuticals
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