ChemicalBook >?? ???? >10-????????????
10-????????????
|
|
10-???????????? ??
- ???
- 75-77 °C (lit.)
- ?? ?
- 330.8±15.0 °C(Predicted)
- ??
- 1.013±0.06 g/cm3(Predicted)
- ?? ??
- Sealed in dry,Room Temperature
- ???
- ?????(?? ???), ???(?? ???)
- ?? ?? (pKa)
- 4.78±0.10(Predicted)
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ???? ?????
- ??? ?? ??
- ?? ????
- ??? ?? ??
- 10-Hydroxydecanoic acid (1679-53-4)
- InChI
- InChI=1S/C10H20O3/c11-9-7-5-3-1-2-4-6-8-10(12)13/h11H,1-9H2,(H,12,13)
- InChIKey
- YJCJVMMDTBEITC-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CCCCCCCCCO
- LogP
- 1.847 (est)
- CAS ??????
- 1679-53-4(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| WGK ?? | 3 | ||
| ?? ?? ?? | Irritant | ||
| HS ?? | 2918199890 | ||
| ???? ??? | 11 - Combustible Solids | ||
| ???? ?? | KE-20437 |
10-???????????? C??? ??, ??, ??
??
10-Hydroxydecanoic acid is suitable for use in a study on Novozym 435-catalyzed condensation polymerization of cis-9,10-epoxy-18-hydroxyoctadecanoic acid and its comparison with corresponding polymerization of 10-hydroxydecanoic acid.??
ChEBI: A 10-carbon, omega-hydroxy fatty acid, shown to be the preferred hydroxylation product (together with the 9-OH isomer) of capric acid in biosystems, and used as a standard in lipid assays; reported to have cytotoxic effects.?? ??
10-Hydroxydecanoic acid (10-HDA) is a saturated fatty acid of hydroxy-trans-2-decenoic acid (10H2DA). Its molecule has two functional groups (-OH and -COOH). It has been reported to prevent the lipopolysaccharide-induced NO production in murine macrophages. 10-HDA has been extracted from royal jelly obtained from honeybees (Apis mellifera) and exhibits estrogenic action. Its polymerization with the polyethylene glycol-modified lipase in a transparent benzene solution has been reported to proceed by the formation of ester linkage.Synthesis
The alkaline cleavage of ricinoleates may be carried out in ethanol at temperatures of 190-200℃ using two to three equivalents of NaOH to give yields up to 69% of pure 10-hydroxydecanoic acid. This method avoids the use of large excesses of alkali as well as the use of high boiling alcohols as reaction media.In a typical experiment we placed 46.8 g (150 mmoles) of methyl ricinoleate and a solution of 12.0 g (300 mmoles) of NaOH in 100 ml of 95% ethanol. The autoclave was placed in an oven at 190-200℃ for 16-18 hr and then cooled to room temperature, vented to remove a certain amount of ethylene (identified by its mass spectrum) produced during heating and opened. After dissolving the semisolid contents in about 500 ml of water, the resulting solution was extracted with three 200 ml portions of ether to remove neutral material. This step may be omitted if it is not desired to retain the 2-octanol formed as coproduct. The aqueous phase was then acidified with 30 ml of concentrated hydrochloric acid, and the liberated acids extracted with two 200 ml portions of ether. After drying over magnesium sulfate and evaporation under reduced pressure to give about 35 g of solid, the crude acids were then dissolved in 100 ml of warm ethyl acetate and 100 ml of heptane was added. After standing overnight at 0℃ the mixture deposited 20.2 g of crystals, mp 71.5-74.5℃ which on recrystallization from benzene, 140 ml, yielded 19.4 g (104 mmoles, 69%) of 10-hydroxydecanoic acid, mp 73-75℃ (lit. 75-76℃). The above conditions are optimal when methyl ricinoleate is utilized, but the cleavage will proceed at lower temperatures. At 160 C about 41% yield of product was obtained after approximately the same reaction time.[1]
10-???????????? ?? ?? ? ???
???
?? ??
10-???????????? ?? ??
???( 341)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177 |
faithe@yan-xi.com | China | 5838 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 |
sales1@chuanghaibio.com | China | 5218 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-17732866630 |
mina@chuanghaibio.com | China | 18114 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +86-15383190639 |
admin@86-ss.com | China | 992 | 58 |
| HANGZHOU HAILAN CHEMICAL CO.,LTD. | +86-57156122185 +86-15967590394 |
sales@hailan-chem.com | China | 2996 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29626 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 |
info@accelachem.com | United States | 21189 | 58 |
| CONIER CHEM AND PHARMA LIMITED | |
sales@conier.com | China | 49906 | 58 |
| career henan chemical co | +86-0371-86658258 |
factory@coreychem.com | China | 29780 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 |
sales@tnjchem.com | China | 34526 | 58 |