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S- (+)-Rolipram

S- (+)-Rolipram ??? ???

?? ??:: 85416-73-5

???:: S- (+)-Rolipram

???(??):: (+)-Rolipram;(S)-(+)-ROLIPRAM;Rolipram (S)-(+)-;S- (+)-Rolipram (ME-3167;(+)-ROLIPRAM;(S)-ROLIPRAM;S- (+)-Rolipram USP/EP/BP;(S)-(+)-Rolipram, 10 mM in DMSO;(S)-(+)-Rolipram, PDE4 inhibitor;Risperidone Impurity 4-d4（Risperidone EP Impurity D-d4）;(4S)-4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone

CBNumber:: CB5397417

???:: C16H21NO3

??? ??:: 275.34

MOL ??:: 85416-73-5.mol

?? ?? 104

S- (+)-Rolipram ??

???: 133-136℃

??: 1.155

?? ??: Sealed in dry,Store in freezer, under -20°C

???: DMSO : 100 mg/mL (363.19 mM; Need ultrasonic)

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?? ? ???? ?? (GHS)

HS ??	2933.79.1500

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P261	??·?·??·???·??·...·????? ??? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

S- (+)-Rolipram C??? ??, ??, ??

??

S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer

??

ChEBI: The (S)-enantiomer of rolipram.

???? ??

Less active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ).

S- (+)-Rolipram ?? ?? ? ???

???

3-CYCLOPENTYLOXY-4-METHOXYBENZALDEHYDE ??????????? ???-???

?? ??

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE

S- (+)-Rolipram ?? ??

???( 104)?? ??

???	??	???	??	?? ?	??
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S- (+)-Rolipram ?? ??:

ZARDAVERINE RO 20-1724 Roflumilast ETAZOLATE BRL 50481 Vinpocetine ZAPRINAST Cilostazol CILOSTAMIDE ROLIPRAM AG 1295 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE EHNA HYDROCHLORIDE (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE S- (+)-Rolipram 4-(3'-Methoxyphenyl)-2-pyrrolidinone 4-(4'-Methoxyphenyl)-2-pyrrolidinone 1-(4-bromobenzyl)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

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