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SCRIPTAID

SCRIPTAID ??? ???
?? ??:
287383-59-9
???:
SCRIPTAID
???(??):
CS-1136;GCK 1026;Scriptide;Scriptaid (GCK1026);Scriptaid, Scriptide;Scriptaid, 10 mM in DMSO;Scriptaid, HDAC inhibitor;GCK 1026; SCRIPTIDE; GCK1026; GCK-1026;6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide;1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-
CBNumber:
CB5504770
???:
C18H18N2O4
??? ??:
326.35
MOL ??:
287383-59-9.mol
MSDS ??:
SDS

SCRIPTAID ??

???
160-161 °C
??
1.338±0.06 g/cm3(Predicted)
?? ??
-20°C
???
DMSO? ?????(?? 4mg/ml).
?? ?? (pKa)
9.46±0.20(Predicted)
??? ??
??? ??.
??
???
???? ??
synthetic (organic)
??
Light Sensitive
???
??? ?? ?????? 2? ?? ??????. DMSO? ???? -20°?? ?? 2?? ?? ??? ? ????.
InChI
InChI=1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
InChIKey
JTDYUFSDZATMKU-UHFFFAOYSA-N
SMILES
C1(=O)C2=C3C(C=CC=C3C(=O)N1CCCCCC(NO)=O)=CC=C2

??

WGK ?? 3
???? ??? 11 - Combustible Solids

SCRIPTAID C??? ??, ??, ??

??

Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems. It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitro and in vivo. Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.

??

Scriptaid has been used in post activation of oocytes and embryo culture.

?? ??

Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.

???? ??

Novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.

SCRIPTAID ?? ?? ? ???

???

?? ??


SCRIPTAID ?? ??

???( 149)?? ??
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