??? ?
|
|
??? ? ??
- ???
- ≥300 °C
- ?? ?
- 280.29°C (rough estimate)
- ??
- 1.6814 (rough estimate)
- ???
- 1.4800 (estimate)
- ?? ??
- Sealed in dry,Room Temperature
- ???
- DMSO : 32 mg/mL (205.00 mM; Need ultrasonic and warming)
- ?? ?? (pKa)
- pK1:1.8(+1);pK2:9.55(0) (25°C)
- ??? ??
- ??? ??
- ??
- ???
- ???
- ?? ???
- Merck
- 13,6942
- BRN
- 383901
- ???
- ????. ?? ???? ???? ????.
- ??? ?? ??
- SKIN CONDITIONING
- InChI
- 1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)
- InChIKey
- PXQPEWDEAKTCGB-UHFFFAOYSA-N
- SMILES
- OC(=O)C1=CC(=O)NC(=O)N1
- LogP
- -0.830
- CAS ??????
- 65-86-1(CAS DataBase Reference)
- NIST
- Orotic acid(65-86-1)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 22-36/37/38 | ||
| ????? | 26-36/37/39-22-37/39 | ||
| WGK ?? | 3 | ||
| RTECS ?? | RM3180000 | ||
| F ?????? | 10-21 | ||
| ?? ?? ?? | Harmful | ||
| TSCA | TSCA listed | ||
| HS ?? | 29335990 | ||
| ???? ??? | 11 - Combustible Solids | ||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
||
| ?? ?? ??? | 65-86-1(Hazardous Substances Data) | ||
| ?? | pic-esc 1 g/L ZAPOAK12,583,72 | ||
| ???? ?? | KE-33452 |
??? ? C??? ??, ??, ??
??? ??
white crystalline powder??
Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5-phospho-α-d-ribose 1-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5-monophosphate (OMP). It is used as a starting material for the potential commercial bioproduction of uridine 5-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. It may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.??
ChEBI: A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.?? ??
White crystals or crystalline powder.??? ?? ??
Slightly soluble in water.????
Flash point data for Orotic acid are not available; however, Orotic acid is probably combustible.Safety Profile
Moderately toxic by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.??? ? ?? ?? ? ???
???
6-Methyluracil
???????
1,3-Bisbenzyl-2-oxoimidazolidine-4,5-dicarboxylic acid
????????? ???????
??????
??
????(???)
??????
??
6-(diethoxymethyl)-2-sulfanylidene-1H-pyrimidin-4-one
Glycoluril
6-FORMYL-URACIL MONOHYDRATE
2-??????
6-(??????)???
????-5-????
????????
6-FORMYL-2-THIOURACIL
URACIL-4-ACETIC ACID
?? ??
??? ? ?? ??
???( 522)?? ??
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