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O-???? ?????

O-???? ?????
O-???? ????? ??? ???
?? ??:
636-21-5
???:
O-???? ?????
???(??):
O-?????????;O-?????????;2-????? ???
???:
O-TOLUIDINE HYDROCHLORIDE
???(??):
nci-c02335;o-ToluidineHCL;2-Toluidine HCl;ORTHO-TOLUIDINEHCL;o-Tolidine hydroch;rcrawastenumberu222;o-Toluidine Chloride;Prilocaine impurity B;PRILOCAINE RC A/ORTHO;O-TOLUIDINIUM CHLORIDE
CBNumber:
CB6264228
???:
C7H10ClN
??? ??:
143.61
MOL ??:
636-21-5.mol
MSDS ??:
SDS

O-???? ????? ??

???
215-217 °C(lit.)
?? ?
242 °C
??
1.0968 (rough estimate)
???
1.5760 (estimate)
?? ??
2-8°C
???
DMSO(?? ???), ???(?? ???), ?(?? ???)
??
???? ????
BRN
3558629
???
????. ???, ???? ???? ????. ?? ??? ?????.
?? ??
???(???)
InChI
InChI=1S/C7H9N.ClH/c1-6-4-2-3-5-7(6)8;/h2-5H,8H2,1H3;1H
InChIKey
OGVXWEOZQMAAIM-UHFFFAOYSA-N
SMILES
C1(C)=CC=CC=C1N.Cl
CAS ??????
636-21-5(CAS DataBase Reference)
EPA
o-Toluidine hydrochloride (636-21-5)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T
?? ???? ?? 45-20/21/22
????? 53-36/37/39-45
????(UN No.) UN 2811 6.1/PG 2
WGK ?? 3
RTECS ?? XU7350000
TSCA TSCA listed
?? ?? 6.1(a)
???? II
HS ?? 2921430000
???? ??? 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Carc. 1B
?? ?? ??? 636-21-5(Hazardous Substances Data)
?????? ??? 97-1-300
?????? ??? ??2-77
?, ??????? ??? 53
?? ? ???? ????: ????; ???(??)????: ????? ? ?? ? ? ? ??? 25% ?? ??? ???. ??, o-????(o-Toluidine)? ?? ?? 0.1% ?? ??? ???
????(GHS): Exclamation Mark (GHS07)Health Hazard (GHS08)
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H350 ?? ??? ? ?? (????? ?? ???? ???? ???? ??? ?? ????? ??? ???? ??) ??? ?? ?? 1A, 1B ??
??????:
P201 ?? ? ?? ???? ?????.
P261 ??·?·??·???·??·...·????? ??? ????.
P280 ????/???/???/?????? ?????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.

O-???? ????? C??? ??, ??, ??

??? ??

white crystalline powder

??

o-Toluidine and o-toluidine hydrochloride are used primarily as intermediates in the manufacture of more than 90 dyes and pigments (NCI 1979, IARC 1982, 2000). They are used in acid-fast dyestuffs, azo pigments and dyes, triarylmethane dyes, sulfur dyes, and indigo compounds and as a photographic dye. o-Toluidine is also used as an intermediate for synthetic rubber and rubber vulcanizing chemicals, pharmaceuticals, and pesticides and as a curing agent in epoxy resin systems. Other minor uses of o-toluidine and its hydrochloride salt are as an intermediate in organic synthesis and as an ingredient in a clinical laboratory reagent for glucose and hemoglobin analyses.

?? ??

Green crystals or white crystalline solid. Melting point 215-217°F. Highly toxic.

??? ?? ??

Insoluble in water.

?? ???

O-TOLUIDINE HYDROCHLORIDE acts as a weak acid. Incompatible with oxidizing agents and with alkalis .

????

Flash point data for O-TOLUIDINE HYDROCHLORIDE are not available; however, O-TOLUIDINE HYDROCHLORIDE is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also o- TOLUIDINE.

Carcinogenicity

o-Toluidine and o-toluidine hydrochloride are reasonably anticipatedto be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals.

O-???? ????? ?? ?? ? ???

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