1-Tetralone
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1-Tetralone ??
- ???
- 2-7 °C(lit.)
- ?? ?
- 113-116 °C6 mm Hg(lit.)
- ??
- 1.099 g/mL at 25 °C(lit.)
- ???
- n
20/D 1.568(lit.)
- ???
- >230 °F
- ?? ??
- 2-8°C
- ???
- ? ????????, ?????? (?? ???)
- ??? ??
- ??
- ??
- ??
- ???
- ???
- BRN
- 607374
- InChI
- 1S/C10H10O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6H,3,5,7H2
- InChIKey
- XHLHPRDBBAGVEG-UHFFFAOYSA-N
- SMILES
- O=C1CCCc2ccccc12
- CAS ??????
- 529-34-0(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 22-20/22-20/21/22 | ||
| ????? | 23-24/25-36 | ||
| WGK ?? | 3 | ||
| RTECS ?? | QK4375000 | ||
| TSCA | TSCA listed | ||
| HS ?? | 29143900 | ||
| ???? ??? | 10 - Combustible liquids | ||
| Hazard Classifications | Acute Tox. 4 Oral | ||
| ?? ?? ??? | 529-34-0(Hazardous Substances Data) | ||
| ?? | LD50 orally in Rabbit: 810 mg/kg LD50 dermal Rabbit > 2200 mg/kg |
1-Tetralone C??? ??, ??, ??
??? ??
Clear amber to brown oily liquid??
1-Tetralone is a reagent used in the synthesis of amino-pyrazolopyridines with anti-NF-κB and pro-apoptotic potential.?? ??
Intramolecular acylation of 4-phenylbutyric acid to 1,2,3,4-tetrahydronaphthalen-1-one (1-Tetralone).
Purification Methods
Check the IR first. Purify α-tetralone by dissolving 20mL in Et2O (200mL), washing with H2O (100mL), 5% aqueous NaOH (100mL), H2O (100mL), 3% aqueous AcOH (100mL), 5% NaHCO3 (100mL) then H2O (100mL) and dry the ethereal layer over MgSO4. Filter, evaporate and fractionate the residue through a 6in Vigreux column (p 11) under reduced pressure to give a colourless oil (~17g) with b 90-91o/0.50.7mm. [Snyder & Werber Org Synth Coll Vol III 798 1955.] It has also been fractionated through a 0.5metre packed column with a heated jacket under reflux using a partial take-off head. It has max 247.5 and 290nm (hexane). The phenylhydrazone has m 83o. The 2,4,6-trinitrophenylhydrazone has m 247.5-248o (from EtOH). [Olson & Bader Org Synth Coll Vol IV 898 1963, Beilstein 7 H 370, 7 III 1416, 7 IV 1015.]1-Tetralone ?? ?? ? ???
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?? ????
?????
4-Phenylbutyric acid
??????????
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2-??-5-?????
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1(2H)-Naphthalenone, 3,4-dihydro-, 2,2-dimethylhydrazone
(4,4-?????-3-??-1-?)??
4-Phenylbutyryl chloride
?? ??
1-Tetralone ?? ??
???( 573)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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1-Tetralone ?? ??:
?????????? ????????? ????????? 2,3-??????-9,10-???????-1,4-?????? 6-???-1-???? 5-????-1-???? ?? 1,4,4A,9A-??????????? 7-???-1-????
Nabumetone
3-BENZOYLPROPIONIC ACID
Sodium 4-phenylbutyrate
4-CYCLOHEXYLBUTYRIC ACID
Tetrahydrothiophen-3-one
1-METHYL-2-TETRALONE
6-hydroxyl-2-tetralone
4-Methyl-1-tetralone
2-Methyl-1-tetralone