Ethyl 3-(pyridin-2-ylamino)propanoate
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Ethyl 3-(pyridin-2-ylamino)propanoate ??
- ???
- 48-50°C
- ?? ?
- 125°C/0.2mmHg(lit.)
- ??
- 1.131±0.06 g/cm3(Predicted)
- ?? ??
- Keep in dark place,Inert atmosphere,2-8°C
- ???
- DMSO????? ???
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 6.26±0.10(Predicted)
- ??
- ???
- InChI
- InChI=1S/C10H14N2O2/c1-2-14-10(13)6-8-12-9-5-3-4-7-11-9/h3-5,7H,2,6,8H2,1H3,(H,11,12)
- InChIKey
- UITNIDFEANEWPC-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)CCNC1C=CC=CN=1
- LogP
- 1.54 at 22℃ and pH6
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- ?? ? ???? ?? (GHS)
| HS ?? | 2933.39.9200 |
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Ethyl 3-(pyridin-2-ylamino)propanoate C??? ??, ??, ??
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White Solid??
Ethyl 3-(2-Pyridylamino)propanoate is an intermediate used in the synthesis of Dabigatran etexilate, as thrombin inhibitors. Ethyl Ester form of P993315.Synthesis
A method for preparing Ethyl 3-(pyridin-2-ylamino)propanoate comprises the following steps: using 2-aminopyridine and ethyl acrylate as raw materials, using anhydrous ethanol as a solvent, using trifluoromethanesulfonic acid as a catalyst, and heating in an oil bath to control the temperature at 120 to 160° C. for a catalytic reaction for 16 to 20 hours under nitrogen protection. The obtained reaction solution is washed with petroleum ether at a temperature of 35 to 40° C. and a pressure of 0.09 to 0.1 MPa, then concentrated under reduced pressure, and then washed with petroleum ether/ethyl acetate and recrystallized to obtain white flaky crystals of Ethyl 3-(pyridin-2-ylamino)propanoate.Ethyl 3-(pyridin-2-ylamino)propanoate ?? ?? ? ???
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Ethyl 3-(pyridin-2-ylamino)propanoate ?? ??
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Ethyl 3-(pyridin-2-ylamino)propanoate ?? ??:
2,3/?????? ???????
4-Aminobenzamidine dihydrochloride
N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate
Dabigatran ethyl AcOH Salt
3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester
ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE
3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER