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??????????? ??? ???
?? ??:
129-49-7
???:
???????????
???(??):
???????????
???:
METHYSERGIDE MALEATE
???(??):
sansert;NSC-186061;deseril-retard;Deseril, Sansert;maleate(1:1)(salt);METHYSERGIDE MALEATE;methysergidedimaleate;methysergidebimaleate;Methysergide Maleate, USP;methysergide maleate salt
CBNumber:
CB8753434
???:
C21H27N3O2.C4H4O4
??? ??:
469.53
MOL ??:
129-49-7.mol

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Store at RT
???
DMSO: >10mg/mL
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Soluble to 10 mM in water with gentle warming
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InChIKey
LWYXFDXUMVEZKS-ZVFOLQIPSA-N
SMILES
[n]1(c2c3c(c1)C[C@H]4N(C[C@@H](C=C4c3ccc2)C(=O)N[C@H](CO)CC)C)C.OC(=O)\C=C/C(=O)O
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T
?? ???? ?? 25
????? 45
????(UN No.) UN 2811 6.1/PG 3
WGK ?? 3
RTECS ?? KE5410000
?? ?? 6.1(b)
???? III
HS ?? 2939690000
???? ??? 6.1C - Combustible, acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
?? mouse,LD50,intravenous,185mg/kg (185mg/kg),"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 101, 1972.
????(GHS): Skull and Crossbones (GHS06)
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? P264, P270, P301+P310, P321, P330,P405, P501
??????:
NFPA 704
0
2 0

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Methysergide maleate salt has been used as a serotonin (5HT) receptor antagonist to evaluate the potential systemic effects of methysergide (METH) and 5-HT infusions on production and milk composition in multiparous Holstein cows. It may also be used as a serotonin receptor blocker to identify the serotonergic receptor type involved in the direct excitation of mitral cells in the main olfactory bulb.

???? ??

Mixed 5-HT 1 /5-HT 2 receptor antagonist.

Safety Profile

Poison by ingestion and intravenous routes. Experimental reproductive effects. Human mutation effects reported. When heated to decomposition it emits toxic fumes of NOx.

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