CS-920;1 NM-PP1;NM-PP1, 1-;Chebi:52309;PP1 ANALOG II;1-NM-PP1 ，S6383;PP1 Analog II, 1NM-PP1;1NM-PP1(PP1 Analog II);1-NM-PP1, 10 mM in DMSO;MUTANT KINASES INHIBITOR II
1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become ‘a(chǎn)nalog sensitive’ (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28 μM, respectively). The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 3.2 nM for c-Fyn-as1 versus 1.0 μM for c-Fyn; 5.0 nM for Cdk2-as1 versus 29 μM for Cdk2; 8.0 nM for CAMKII-as1 versus 24 μM for CAMKII). This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems.
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White Cyrstalline Solid
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A highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase
