Memantine HCl
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Memantine HCl ??
- ???
- 292 °C
- ?? ??
- Inert atmosphere,2-8°C
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- ?? ???(?? 20mg/ml)
- ??? ??
- ?? ??
- ??
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- Soluble in water (100mM)
- Merck
- 14,5806
- ???
- ??? ?? ?????? 1? ?? ??????. ??? ??? -20°C?? ?? 2?? ?? ??? ? ????.
- InChI
- InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
- InChIKey
- LDDHMLJTFXJGPI-UHFFFAOYSA-N
- SMILES
- C12(N)CC3(C)CC(CC(C)(C3)C1)C2.[H]Cl
- CAS ??????
- 41100-52-1(CAS DataBase Reference)
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- ?? ? ???? ?? (GHS)
| ????? | 24/25 | ||
|---|---|---|---|
| WGK ?? | 3 | ||
| ?? ?? | IRRITANT | ||
| HS ?? | 29213000 | ||
| ???? ??? | 11 - Combustible Solids |
Memantine HCl C??? ??, ??, ??
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Memantine, a NMDA receptor antagonist, was co-developed by Forest Laboratories with Merz Pharmaceuticals and marketed under the trade name Namenda for the treatment of Alzheimer’s disease in the US after its approval in October, 2003. This drug has been available in many European and Asian markets before getting approval in the US.??? ??
Crystalline Solid?? ??
Memantine HCl has been used:- as a media supplement to serve as a control to study the neuroprotective effects of erythropoietin in N-methyl-D-aspartate receptor-induced toxicity.
- to intraperitoneally inject experimental animal to study its effect on traumatic injury.
- as a test compound to determine the dynamic range and selectivity of retinal pigment epithelium tissue penetration.
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Used as an antiparkinsonian and antispasmodic??
ChEBI: A hydrochloride obtained by reaction of memantine with one equivalent of hydrochloric acid. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.?? ??
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.Memantine Hydrochloride is a drug used for treating the Alzheimer′s disease by means of reducing abnormal activity in the brain. It can help patients suffering from dementia as it assists them to think more clearly and perform their chores with ease.
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Serious side effects:Allergic reaction. Symptoms can include: swelling of your tongue, lips, or face; shortness of breath; skin rash; hives
Hepatitis (inflammation of the liver). Symptoms can include: yellowing of your skin or the whites of your eyes.
Pancreatitis (inflammation of the pancreas). Symptoms can include: severe nausea; severe abdominal pain.
Change in mental health. Symptoms can include: hallucinations; thoughts of suicide.
Congestive heart failure. Symptoms can include: shortness of breath; swelling in your feet and ankles.
Memantine HCl ?? ?? ? ???
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Acetamide, 2-chloro-N-(3,5-dimethyltricyclo[3.3.1.13,7]dec-1-yl)-
1-???-3,5-???????
3,5-???-1-??????
N-(3,5-???????-1-?)(MaMide)
Memantine
1-??-3,5-????????
1-????-3,5-???????
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Memantine HCl ?? ??
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