4-??????
|
|
4-?????? ??
- ???
- 56-62 °C (lit.)
- ?? ?
- 230-250 °C
- ??
- 1.497
- ?? ??
- 810kg/m3
- ???
- 1.5680 (estimate)
- ???
- 222-224°C
- ?? ??
- Store below +30°C.
- ???
- ???: ???0.5g/10mL, ??, ??~?? ??
- ??? ??
- ?? ??
- ?? ?? (pKa)
- 3.86(at 25℃)
- ??
- ???? ?? ???
- ??
- ???
- ???
- 23&C?? <0.1g/100mL
- Merck
- 14,1404
- BRN
- 742031
- Henry's Law Constant
- 1.1×101 mol/(m3Pa) at 25℃, HSDB (2015)
- Dielectric constant
- 13.0（-7℃）
- ???
- ????. ?? ??. ?? ???, ????, ?, ? ???, ? ???, ????????? ???? ????. ??? ??? ? ????.
- InChI
- 1S/C6H6BrN/c7-5-1-3-6(8)4-2-5/h1-4H,8H2
- InChIKey
- WDFQBORIUYODSI-UHFFFAOYSA-N
- SMILES
- Nc1ccc(Br)cc1
- CAS ??????
- 106-40-1(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 21/22-36/37/38-20/21/22 | ||
| ????? | 26-36/37-36/37/39 | ||
| ????(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK ?? | 3 | ||
| RTECS ?? | BW9280000 | ||
| F ?????? | 8-9-23 | ||
| ?? ?? ?? | Harmful | ||
| TSCA | TSCA listed | ||
| ?? ?? | 6.1 | ||
| ???? | III | ||
| HS ?? | 29214210 | ||
| ???? ??? | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 STOT RE 2 |
||
| ?? ?? ??? | 106-40-1(Hazardous Substances Data) | ||
| ?? | LD50 orally in Rabbit: 456 mg/kg LD50 dermal Rat 536 mg/kg | ||
| ???? ?? | KE-03623 |
4-?????? C??? ??, ??, ??
??? ??
Gray-brown crystals with a peculiar odor. When heated or burned, they break down and release harmful fumes that contain hydrogen bromide and nitrogen oxides. When dissolved in water, it acts as a mild base. It reacts with acids and powerful oxidizing agents. The compound 4-bromoaniline consists of a hydrophobic benzene ring and an amino group that assists in carrying substances and improving PSC stability.??
4-Bromoaniline is a brominated aniline that is commonly used as a building block in the preparation of pharmaceutical and organic compounds. It is used in the preparation of azo dyes and is condensed with formaldehyde to prepare dihydroquinazolines. In addition, 4-Bromoaniline is also used as an intermediate in the production of other chemicals such as metobromuron, a herbicide, and resorantel, an antiparasitic agent.?? ??
4-bromoaniline can be made by reacting aniline with bromine with a protection with acetyl chloride.?? ??
P-bromoaniline is a brown solid with a sweet odor. (NTP, 1992)??? ?? ??
4-Bromoaniline is sensitive to prolonged exposure to air. Vapor may form highly reactive mixtures in air . Insoluble in water.?? ???
Vapor may form highly reactive mixtures in air.????
Flash point data are not available for 4-Bromoaniline, but 4-Bromoaniline is probably combustible.Synthesis
RGO/Cu NPs (25 mg), arylboronic acid (1.0 mmol), K2CO3(1.3 mmol), 25-28% aqueous ammonia (5 mmol) and methanol(4 mL) were added to a 50 mL round-bottomed flask. The reactionmixture was stirred under reflux conditions for the appropriatetime. After completion of the reaction as monitored by TLC, themixture was filtered, and the solvent of the filtrate was removedunder vacuum with the aid of a rotary evaporator. The residue waspurified by column chromatography on silica gel to afford 4-Bromoaniline.Purification Methods
Crystallise the aniline (with appreciable loss) from aqueous EtOH. The benzoyl derivative has m 204o (from EtOH). [Beilstein 12 IV 1497.]4-?????? ?? ?? ? ???
???
4-???????
??
???(II)
??? ????
1-Bromo-4-nitrobenzene
?????
??? ???
4-Bromophenylboronic acid
1-Bromo-4-iodobenzene
???
?? ??
4-???-2-????????
6-bromoquinolin-4(3H)-one
polyaniline synthesized by means of condensation polymerization
6-Bromoquinoline
4-???????
6-BROMO-4-CHLOROQUINOLINE
4-(4-??????-1-?)?????
4-BROMOPHENYLUREA
4-????? ??? ??? ????
4'-??????????
4-??????
2-(4-?????)???
2-???-6-????????
brotianide
5-(4-?????)????
4-BROMOPHENYLTHIOUREA
4,4'-????????
Diazene, (4-bromophenyl)(4-chlorophenyl)- (9CI)
????????
4-?????? ?? ??
???( 558)?? ??
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