D-Phenylalanine
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D-Phenylalanine ??
- ???
- 273-276 °C(lit.)
- ?? ?
- 293.03°C (rough estimate)
- ??
- 33.5 º (c=2, H2O)
- ??
- 1.1603 (rough estimate)
- ???
- 34 ° (C=2, H2O)
- ?? ??
- Store at RT.
- ???
- ???(?? ???), ?(?? ???)
- ??? ??
- ??
- ?? ?? (pKa)
- 2.2(at 25℃)
- ??
- ???? ?????
- ???
- 27 g/L (20 ºC)
- Merck
- 14,7271
- BRN
- 2804068
- ???
- ????. ?? ???, ?, ??? ???? ????.
- ?? ??
- ?? ??
- InChI
- 1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m1/s1
- InChIKey
- COLNVLDHVKWLRT-MRVPVSSYSA-N
- SMILES
- N[C@H](Cc1ccccc1)C(O)=O
- LogP
- 0.235 (est)
- CAS ??????
- 673-06-3(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi,C | ||
|---|---|---|---|
| ?? ???? ?? | 34 | ||
| ????? | 24/25-45-36/37/39-27-26 | ||
| WGK ?? | 3 | ||
| RTECS ?? | AY7533000 | ||
| ?? ?? ?? | Irritant | ||
| TSCA | TSCA listed | ||
| HS ?? | 29224995 | ||
| ???? ??? | 11 - Combustible Solids | ||
| ?? | TDLo orl-hmn: 500 mg/kg/5W-I:GIT JACTDZ 1(3),124,82 |
D-Phenylalanine C??? ??, ??, ??
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D-Phenylalanine, also known as D-alpha-Amino-beta-phenylpropionic acid, is a kind of non-proteinogenic amino acid. The biological function of D-phenylalanine remains unclear. However, it has certain anti-depressant, analgesic activities and pharmacological activity at niacin receptor II. The mechanism action of its analgesic activity seems to originate from its inhibition of enkephalin degradation by the carboxypeptidase A. Enkephalins are part of your body’s natural pain relief system. When they are broken down by enkephalinase, this contributes to the sensation of pain. D-Phenylalanine is specifically thought to be beneficial for reducing feelings of chronic pain. D-phenylalanine has been used with mixed results to treat chronic pain, including pain caused by rheumatoid arthritis. The primary use of D-phenylalanine as a health supplement is the relief of discomfort.??? ??
White crystalline powder??
D-Phenylalanine, the stereoisomer of L-Phenylalanine (P319415) has been used in the synthesis of Schaeffer’s acid analogues as important structures in tuberculostatic design. They exhibit the ability to inhibit Mycobacterium tuberculosis type II dehydroquinase.??
ChEBI: D-phenylalanine is the D-enantiomer of phenylalanine. It is a phenylalanine and a D-alpha-amino acid. It is a conjugate base of a D-phenylalaninium. It is a conjugate acid of a D-phenylalaninate. It is an enantiomer of a L-phenylalanine. It is a tautomer of a D-phenylalanine zwitterion.?? ??
D-phenylalanine appears as needles or prisms.??? ?? ??
Water soluble. Aqueous solutions are weakly acidic.?? ???
D-alpha-Amino-beta-phenylpropionic acid may be light sensitive. D-alpha-Amino-beta-phenylpropionic acid reacts with strong oxidizing agents, acids and bases. . Act as weak acids in solution.????
Flash point data for D-alpha-Amino-beta-phenylpropionic acid are not available, however D-alpha-Amino-beta-phenylpropionic acid is probably combustible.Safety Profile
Mildly toxic by intraperitoneal route. Human systemic effects by ingestion: nausea, hypermotility, diarrhea. When heated to decomposition it emits toxic fumes of NOx.Source
D-Phenylalanine is not found in nature. It is commonly produced through the fermentation and modification of specialized bacterial cultures, such as Escherichia coli, or synthesized chemically as a targeted dietary supplement.?? ??
https://www.alfa.com/en/catalog/A10572/https://en.wikipedia.org/wiki/Phenylalanine
Christianson, D. W., et al. "Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A. " Journal of Biological Chemistry264.22(1989):12849-53.
D-Phenylalanine ?? ?? ? ???
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D-Phenylalanine ?? ??
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|---|---|---|---|---|---|
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D-Phenylalanine ?? ??:
L????? D-??? ????(??) ??? L-3-???????? L-3-???????
D-Tyrosine
D(+)-Tryptophan
D(-)-Arginine
D-Alanine Methyl Ester Hydrochloride
D-Alanine tert-butyl ester hydrochloride
D-Phenylalanine methyl ester hydrochloride
D-Prolinamide
D-Alanyl-D-alanine
Fmoc-L-glutamic acid
FMOC-LYS-OH
Di-tert-butyl dicarbonate
S-Trityl-L-cysteine