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Properties

Melting point:: 168-1700C

Flash point:: 9℃

storage temp.: 2-8°C

solubility: H₂O: 50 mg/mL

form: crystalline

color: white

PH: 4.2～5.2(100g/l,25℃)

Water Solubility: Soluble in water

λmax: 260nm(lit.)

Merck: 14,4920

InChI: 1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H

InChIKey: XZZXIYZZBJDEEP-UHFFFAOYSA-N

SMILES: Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13

CAS DataBase Reference: 113-52-0(CAS DataBase Reference)

EPA Substance Registry System: 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, monohydrochloride (113-52-0)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H300

Precautionary statements: P264-P270-P301+P310-P405-P501

Hazard Codes: Xn,T,F

Risk Statements: 23/25-36/38-36/37/38-22-39/23/24/25-23/24/25-11

Safety Statements: 7-16-24-33-45-36-26-36/37

RIDADR: UN 1230 3/PG 2

WGK Germany: 3

RTECS: HO1925000

TSCA: TSCA listed

HS Code: 2933995800

Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications: Acute Tox. 2 Oral

Toxicity: LD50 in mice, rats (mg/kg): 400, 490 orally; 110, 90 i.p. (Tobe)

Use

Imipramine hydrochloride, 5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine monohydrochloride(Tofranil), is the lead compound of the TCAs. It is also a closerelative of the antipsychotic phenothiazines (replace the10–11 bridge with sulfur, and the compound is the antipsychoticagent promazine). It has weaker D2 postsynaptic blockingactivity than promazine and mainly affects amines (5-HT,NE, and DA) via the transporters. As is typical of dimethylaminocompounds, anticholinergic and sedative (central H1block) effects tend to be marked. The compound per se has a tendency toward a high 5-HT-to-NE uptake block ratio andprobably can be called a serotonin transport inhibitor(SERTI). Metabolic inactivation proceeds mainly by oxidativehydroxylation in the 2-position, followed by conjugationwith glucuronic acid of the conjugate. Urinary excretion predominates(about 75%), but some biliary excretion (up to25%) can occur, probably because of the large nonpolargrouping. Oxidative hydroxylation is not as rapid or completeas that of the more nucleophilic ring phenothiazine antipsychotics;consequently, appreciable N-demethylation occurs,with a buildup of norimipramine (or desimipramine).