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Properties

Melting point:: 226°C (dec.)

storage temp.: Amber Vial, Refrigerator

solubility: H₂O: 25 mg/mL

form: powder

color: white

PH: pH (20g/l, 25℃) : 3.0～4.0

Water Solubility: freely soluble

Sensitive: Light Sensitive

Merck: 14,7019

BRN: 3921435

Stability:: Stable, but may be light sensitive.

InChI: InChI=1S/C20H21NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-8,10-12H,9H2,1-4H3;1H

InChIKey: UOTMYNBWXDUBNX-UHFFFAOYSA-N

SMILES: C1(CC2=CC=C(OC)C(OC)=C2)=C2C(C=C(OC)C(OC)=C2)=CC=N1.[H]Cl

CAS DataBase Reference: 61-25-6(CAS DataBase Reference)

EPA Substance Registry System: Papaverine hydrochloride (61-25-6)

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301

Precautionary statements: P264-P270-P301+P310-P405-P501

PPE: dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes: Xn,C,F

Risk Statements: 22-34-11

Safety Statements: 22-45-36/37/39-26-16

RIDADR: UN 1544 6.1/PG 3

WGK Germany: 1

RTECS: NW8575000

F: 8

TSCA: TSCA listed

HazardClass: 6.1

PackingGroup: III

HS Code: 29391900

Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications: Acute Tox. 3 Oral

Toxicity: LD50 in mice, rats (mg/kg): 27.5, 20 i.v.; 150, 370 s.c. (Levis)

Use

Papaverine hydrochloride,6,7-dimethoxy-1-veratrylisoquinoline hydrochloride,was isolated by Merck in 1848 from opium,in which it occurs to the extent of about 1%. Althoughits natural origin is closely related to morphine, the pharmacologicalactions of papaverine hydrochloride areunlike those of morphine. Its main effect is as a spasmolyticon smooth muscle, acting as a direct, nonspecificrelaxant on vascular, cardiac, and other smooth muscle.Because of its broad antispasmodic action on ACh muscarinicreceptors, it is often called a nonspecific antagonist.Papaverine hydrochloride has been used in the treatmentof peripheral vascular disorders, but its use is limitedby lack of potency. Papaverine hydrochloride interferes with the mechanismof muscle contraction by inhibiting the cyclic nucleotidephosphodiesterases in smooth muscle cells responsible forconverting cAMP and cyclic guanosine monophosphate(cGMP) to 5' -AMP and 5' -GMP, respectively. The increasedlevels of cAMP and cGMP are associated with muscle relaxation through their phosphorylation of myosinlight-chain kinase.PAPAVERINE HYDROCHLORIDE is Crystalline Solid Papaverine hydrochloride,6,7-dimethoxy-1-veratrylisoquinoline hydrochloride,was isolated by Merck in 1848 from opium,in which it occurs to the extent of about 1%. Althoughits natural origin is closely related to morphine, the pharmacologicalactions of papaverine hydrochloride areunlike those of morphine. Its main effect is as a spasmolyticon smooth muscle, acting as a direct, nonspecificrelaxant on vascular, cardiac, and other smooth muscle.Because of its broad antispasmodic action on ACh muscarinicreceptors, it is often called a nonspecific antagonist.Papaverine hydrochloride has been used in the treatmentof peripheral vascular disorders, but its use is limitedby lack of potency. Papaverine hydrochloride interferes with the mechanismof muscle contraction by inhibiting the cyclic nucleotidephosphodiesterases in smooth muscle cells responsible forconverting cAMP and cyclic guanosine monophosphate(cGMP) to 5' -AMP and 5' -GMP, respectively. The increasedlevels of cAMP and cGMP are associated with muscle relaxation through their phosphorylation of myosinlight-chain kinase.