3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
![3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)- price.](/CAS/GIF/120964-45-6.gif)
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- $63 - $3156.5
- Product name: 3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-
- CAS: 120964-45-6
- MF: C12H15ClN4O3
- MW: 298.7255
- EINECS:
- MDL Number:MFCD18782644
- Synonyms:3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-;3-Deazaneplanocin A (hydrochloride);3-Deazaneplanocin hydrochloride;DZNep hydrochloride;NSC 617989 hydrochloride;(-)-1-[(1R,4R,5S)-3-(HydroxyMethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aMinoiMidazo[4,5-c]pyridine hydrochloride DZNep hydrochloride;(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol hydrochloride (1:1);1H-Imidazo[4,5-c]pyridine, 3-cyclopentene-1,2-diol deriv.
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Brand
- aablocks
- ACHEMBLOCK
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 500μg
- 1mg
- 2mg
- 50mg
- 100mg
- 1
- 500ug
- 10mM(in1mLDMSO)
- 5mg
- 10mg
- 25mg
- 10mM(in 1mL DMSO)
- Manufactureraablocks
- Product numberAA003B83
- Product description3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, hydrochloride (1:1), (1S,2R,5R)- 98%
- Packaging1mg
- Price$63
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003B83
- Product description3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, hydrochloride (1:1), (1S,2R,5R)- 98%
- Packaging5mg
- Price$204
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003B83
- Product description3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, hydrochloride (1:1), (1S,2R,5R)- 98%
- Packaging10mg
- Price$320
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003B83
- Product description3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, hydrochloride (1:1), (1S,2R,5R)- 98
- Packaging25mg
- Price$671
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228767
- Product description3-deazaneplanocin A hydrochloride 97.00%
- Packaging25MG
- Price$975
- Updated2026-05-27
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- ManufacturerACHEMBLOCK
- Product numberY228767
- Product description3-deazaneplanocin A hydrochloride 97.00%
- Packaging5MG
- Price$355
- Updated2026-05-27
- Buy
- ManufacturerAmbeed
- Product numberA746301
- Product description3-Deazaneplanocin A hydrochloride 98+%
- Packaging5mg
- Price$301
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA746301
- Product description3-Deazaneplanocin A hydrochloride 98+%
- Packaging1mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8182
- Product description3-Deazaneplanocin A (DZNep) hydrochloride
- Packaging10mM(in1mLDMSO)
- Price$264
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8182
- Product description3-DeazaneplanocinA(DZNep)hydrochloride
- Packaging1mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8182
- Product description3-Deazaneplanocin A (DZNep) hydrochloride
- Packaging1mg
- Price$88
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8182
- Product description3-Deazaneplanocin A (DZNep) hydrochloride
- Packaging5mg
- Price$385
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8182
- Product description3-DeazaneplanocinA(DZNep)hydrochloride
- Packaging5mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8182
- Product description3-DeazaneplanocinA(DZNep)hydrochloride
- Packaging10mM(in 1mL DMSO)
- Price$296
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8182
- Product description3-Deazaneplanocin A (DZNep) hydrochloride
- Packaging25mg
- Price$990
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8182
- Product description3-DeazaneplanocinA(DZNep)hydrochloride
- Packaging25mg
- Price$900
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA003B83 | 3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, hydrochloride (1:1), (1S,2R,5R)- 98% | 1mg | $63 | 2026-05-28 | Buy |
| aablocks | AA003B83 | 3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, hydrochloride (1:1), (1S,2R,5R)- 98% | 5mg | $204 | 2026-05-28 | Buy |
| aablocks | AA003B83 | 3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, hydrochloride (1:1), (1S,2R,5R)- 98% | 10mg | $320 | 2026-05-28 | Buy |
| aablocks | AA003B83 | 3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, hydrochloride (1:1), (1S,2R,5R)- 98 | 25mg | $671 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228767 | 3-deazaneplanocin A hydrochloride 97.00% | 25MG | $975 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228767 | 3-deazaneplanocin A hydrochloride 97.00% | 5MG | $355 | 2026-05-27 | Buy |
| Ambeed | A746301 | 3-Deazaneplanocin A hydrochloride 98+% | 5mg | $301 | 2021-12-16 | Buy |
| Ambeed | A746301 | 3-Deazaneplanocin A hydrochloride 98+% | 1mg | $135 | 2021-12-16 | Buy |
| ApexBio Technology | A8182 | 3-Deazaneplanocin A (DZNep) hydrochloride | 10mM(in1mLDMSO) | $264 | 2026-05-06 | Buy |
| ApexBio Technology | A8182 | 3-DeazaneplanocinA(DZNep)hydrochloride | 1mg | $80 | 2021-12-16 | Buy |
| ApexBio Technology | A8182 | 3-Deazaneplanocin A (DZNep) hydrochloride | 1mg | $88 | 2026-05-06 | Buy |
| ApexBio Technology | A8182 | 3-Deazaneplanocin A (DZNep) hydrochloride | 5mg | $385 | 2026-05-06 | Buy |
| ApexBio Technology | A8182 | 3-DeazaneplanocinA(DZNep)hydrochloride | 5mg | $350 | 2021-12-16 | Buy |
| ApexBio Technology | A8182 | 3-DeazaneplanocinA(DZNep)hydrochloride | 10mM(in 1mL DMSO) | $296 | 2021-12-16 | Buy |
| ApexBio Technology | A8182 | 3-Deazaneplanocin A (DZNep) hydrochloride | 25mg | $990 | 2026-05-06 | Buy |
| ApexBio Technology | A8182 | 3-DeazaneplanocinA(DZNep)hydrochloride | 25mg | $900 | 2021-12-16 | Buy |
Properties
Melting point :168-169℃
storage temp. :-20°C
solubility :H2O: ≥5mg/mL
form :Tan solid
color :white to beige
optical activity :[α]/D -88 to -108°, c =0.1 in water
Water Solubility :Soluble in water (10mM)
InChI :InChI=1/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H/t8-,10-,11+;/s3
InChIKey :UNSKMHKAFPRFTI-FDKLLANESA-N
SMILES :C1[C@@H]([n]2c3ccnc(N)c3nc2)[C@H](O)[C@H](O)C=1CO.Cl |&1:1,12,14,r|
storage temp. :-20°C
solubility :H2O: ≥5mg/mL
form :Tan solid
color :white to beige
optical activity :[α]/D -88 to -108°, c =0.1 in water
Water Solubility :Soluble in water (10mM)
InChI :InChI=1/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H/t8-,10-,11+;/s3
InChIKey :UNSKMHKAFPRFTI-FDKLLANESA-N
SMILES :C1[C@@H]([n]2c3ccnc(N)c3nc2)[C@H](O)[C@H](O)C=1CO.Cl |&1:1,12,14,r|
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
The lysine methyltransferase EZH2 (KMT6), part of the polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells. 3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase. It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells in a dose-dependent manner (0.2-1 μM). 3-Deazaneplanocin A treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis. When used in combination with the pan-histone deacetylase inhibitor panobinostat (10 mg/kg), 3-deazaneplanocin A’s (1 mg/kg) antileukemic effects are synergistically enhanced in mice implanted with AML cells.Related product price
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![3-Cyclopentene-1,2-diol, 5-(4-aMino-1H-iMidazo[4,5-c]pyridin-1-yl)-3-(hydroxyMethyl)-, (Hydrochloride) (1:1), (1S,2R,5R)-](https://img.chemicalbook.com/ProductImageEN/2019-12/small/5a1f7e34-ce06-49f8-aa87-54afe3ad4a94.jpg){kind=small}
