2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
![2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione price.](/CAS/20150408/GIF/1218942-37-0.gif)
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- $9 - $2055
- Product name: 2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
- CAS: 1218942-37-0
- MF: C21H19ClN4O2
- MW: 394.85
- EINECS:942-974-8
- MDL Number:MFCD27923122
- Synonyms:2-(2-Chlorophenyl)-4-(3-(diMethylaMino)phenyl)-5-Methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione;2-(2-chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1,2-dihydro-5H-pyrazolo[4,3-c]pyridine-3,6-dione;2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione GKT137831;GKT137831, >=98%;2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-;CS-1795;GKT-137831;GKT 137831;Setanaxib GKT137831
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Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25MG
- 2x25mg
- 10mM*1mLinDMSO
- 50mg
- 100mg
- 100.00mg
- 200mg
- 250.00mg
- 250mg
- 500mg
- 1.00g
- 1G
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM(1mLinDMSO)
- Manufactureraablocks
- Product numberAA001697
- Product descriptionGKT-137831 97%
- Packaging50mg
- Price$36
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001697
- Product descriptionGKT-137831 97%
- Packaging100mg
- Price$52
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001697
- Product descriptionGKT-137831 97%
- Packaging250mg
- Price$87
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001697
- Product descriptionGKT-137831 97%
- Packaging10mg
- Price$16
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001697
- Product descriptionGKT-137831 97%
- Packaging5mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001697
- Product descriptionGKT-137831 97%
- Packaging1mg
- Price$9
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32838
- Product descriptionGKT137831 98%
- Packaging5MG
- Price$40
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32838
- Product descriptionGKT137831 98%
- Packaging5MG
- Price$40
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32838
- Product descriptionGKT137831 98%
- Packaging25MG
- Price$120
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32838
- Product descriptionGKT137831 98%
- Packaging25MG
- Price$120
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32838
- Product descriptionGKT137831 98%
- Packaging100MG
- Price$335
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32838
- Product descriptionGKT137831 98%
- Packaging100MG
- Price$335
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32838
- Product descriptionGKT137831 98%
- Packaging1G
- Price$1535
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberO32838
- Product descriptionGKT137831 98%
- Packaging1G
- Price$1535
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX3563
- Product descriptionGKT137831
- Packaging10mg
- Price$284
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4763
- Product descriptionGKT137831
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA001697 | GKT-137831 97% | 50mg | $36 | 2026-05-28 | Buy |
| aablocks | AA001697 | GKT-137831 97% | 100mg | $52 | 2026-05-28 | Buy |
| aablocks | AA001697 | GKT-137831 97% | 250mg | $87 | 2026-05-28 | Buy |
| aablocks | AA001697 | GKT-137831 97% | 10mg | $16 | 2026-05-28 | Buy |
| aablocks | AA001697 | GKT-137831 97% | 5mg | $12 | 2026-05-28 | Buy |
| aablocks | AA001697 | GKT-137831 97% | 1mg | $9 | 2026-05-28 | Buy |
| ACHEMBLOCK | O32838 | GKT137831 98% | 5MG | $40 | 2026-05-25 | Buy |
| ACHEMBLOCK | O32838 | GKT137831 98% | 5MG | $40 | 2026-05-27 | Buy |
| ACHEMBLOCK | O32838 | GKT137831 98% | 25MG | $120 | 2026-05-25 | Buy |
| ACHEMBLOCK | O32838 | GKT137831 98% | 25MG | $120 | 2026-05-27 | Buy |
| ACHEMBLOCK | O32838 | GKT137831 98% | 100MG | $335 | 2026-05-25 | Buy |
| ACHEMBLOCK | O32838 | GKT137831 98% | 100MG | $335 | 2026-05-27 | Buy |
| ACHEMBLOCK | O32838 | GKT137831 98% | 1G | $1535 | 2026-05-25 | Buy |
| ACHEMBLOCK | O32838 | GKT137831 98% | 1G | $1535 | 2026-05-27 | Buy |
| AK Scientific | X3563 | GKT137831 | 10mg | $284 | 2021-12-16 | Buy |
| ApexBio Technology | B4763 | GKT137831 | 10mg | $160 | 2021-12-16 | Buy |
Properties
Boiling point :560.5±60.0 °C(Predicted)
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 65 mg/ml).
form :solid
pka :5.13±0.25(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Density :1.42±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (up to 65 mg/ml).
form :solid
pka :5.13±0.25(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
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Description
NADPH oxidase 1 (NOX1) and NOX4 generate reactive oxygen species (ROS) that are critical in regulating a variety of cellular functions but also contribute to many diseases. GKT137831 is a dual inhibitor of both NOX1 and NOX4 with Ki values in the range of 100 to 150 nM in cell-free assays of ROS production. It shows only weak inhibitory activity against NOX2 or xanthine oxidase and does not block neutrophil oxidative burst, scavenge ROS, or have antioxidant activity. GKT137831 displays good oral bioavailability with high plasma concentrations in vivo and attenuates liver fibrosis in mice. It reduces hypoxia-induced pulmonary vascular cell proliferation, ameliorates dopaminergic neuronal death, and provides renoprotection in long-term diabetic nephropathy.Related product price
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