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ChemicalBook >> CAS DataBase List >> BI 2536

BI 2536

BI 2536 price.
  • $30 - $2841
  • Product name: BI 2536
  • CAS: 755038-02-9
  • MF: C28H39N7O3
  • MW: 521.65
  • EINECS:1308068-626-2
  • MDL Number:MFCD10565924
  • Synonyms:BI-2536, BoehringerPLK-1 inhibitor;4-[[(7R)-8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide;BI 2536;Benzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-;Boehringer PLK-1 inhibitor;BI-2536(R-);BI2536/BI-2536;(R)-4-((8-cyclopentyl-7-ethyl-5-Methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)aMino)-3-Methoxy-N-(1-Methylpiperidin-4-yl)benzaMide
110 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • Adipogen Life Sciences
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
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  • Usbiological
Package
  • 200mg
  • 500mg
  • 0.5g
  • 1000mg
  • 5.00g
  • 10.00g
  • 10mM*1mLinDMSO
  • 50.00g
  • 1 unit
  • 5 mg
  • 25 mg
  • 10mM(1mLinDMSO)
  • 1mg
  • 5mg
  • EvaluationSample
  • 10mg
  • 20MG
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1G
  • 10mM(in1mLDMSO)
  • Manufactureraablocks
  • Product numberAA00G2II
  • Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide ≥98%
  • Packaging5mg
  • Price$43
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00G2II
  • Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide ≥98%
  • Packaging10mg
  • Price$76
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00G2II
  • Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide
  • Packaging25mg
  • Price$121
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00G2II
  • Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide 99%
  • Packaging1mg
  • Price$35
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00G2II
  • Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide 99%
  • Packaging50mg
  • Price$146
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00G2II
  • Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide 99%
  • Packaging100mg
  • Price$262
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00G2II
  • Product description(R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide ≥98%
  • Packaging250mg
  • Price$507
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product number10293
  • Product descriptionBI 2536 98%
  • Packaging1G
  • Price$1150
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product number10293
  • Product descriptionBI 2536 98%
  • Packaging100MG
  • Price$350
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10293
  • Product descriptionBI 2536 98%
  • Packaging25MG
  • Price$145
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product number10293
  • Product descriptionBI 2536 98%
  • Packaging5MG
  • Price$65
  • Updated2026-05-27
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  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1019-M005
  • Product description(R)-BI-2536 ≥95%
  • Packaging5mg
  • Price$124
  • Updated2021-12-16
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  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1019-M001
  • Product description(R)-BI-2536 ≥95%
  • Packaging1mg
  • Price$86
  • Updated2026-05-06
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  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1019-M005
  • Product description(R)-BI-2536 ≥95%
  • Packaging5mg
  • Price$124
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1019-M010
  • Product description(R)-BI-2536 ≥95%
  • Packaging10mg
  • Price$211
  • Updated2026-05-06
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  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1019-M050
  • Product description(R)-BI-2536 ≥95%
  • Packaging50mg
  • Price$702
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00G2II (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide ≥98% 5mg $43 2026-05-28 Buy
aablocks AA00G2II (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide ≥98% 10mg $76 2026-05-28 Buy
aablocks AA00G2II (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide 25mg $121 2026-05-28 Buy
aablocks AA00G2II (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide 99% 1mg $35 2026-05-28 Buy
aablocks AA00G2II (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide 99% 50mg $146 2026-05-28 Buy
aablocks AA00G2II (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide 99% 100mg $262 2026-05-28 Buy
aablocks AA00G2II (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide ≥98% 250mg $507 2026-05-28 Buy
ACHEMBLOCK 10293 BI 2536 98% 1G $1150 2026-05-27 Buy
ACHEMBLOCK 10293 BI 2536 98% 100MG $350 2026-05-27 Buy
ACHEMBLOCK 10293 BI 2536 98% 25MG $145 2026-05-27 Buy
ACHEMBLOCK 10293 BI 2536 98% 5MG $65 2026-05-27 Buy
Adipogen Life Sciences SYN-1019-M005 (R)-BI-2536 ≥95% 5mg $124 2021-12-16 Buy
Adipogen Life Sciences SYN-1019-M001 (R)-BI-2536 ≥95% 1mg $86 2026-05-06 Buy
Adipogen Life Sciences SYN-1019-M005 (R)-BI-2536 ≥95% 5mg $124 2026-05-06 Buy
Adipogen Life Sciences SYN-1019-M010 (R)-BI-2536 ≥95% 10mg $211 2026-05-06 Buy
Adipogen Life Sciences SYN-1019-M050 (R)-BI-2536 ≥95% 50mg $702 2026-05-06 Buy

Properties

Density :1.28
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 25 mg/ml)
form :Yellow powder.
pka :14.09±0.20(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :XQVVPGYIWAGRNI-JOCHJYFZSA-N
SMILES :C(NC1CCN(C)CC1)(=O)C1=CC=C(NC2=NC=C3C(=N2)N(C2CCCC2)[C@H](CC)C(=O)N3C)C(OC)=C1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. BI 2536 is a 2-aminopyrimidine-containing inhibitor of Plk1 (IC50 = 0.83 nM). It displays 4- and 11-fold selectivity for Plk1 over Plk2 and Plk3, respectively. BI 2536 induces mitotic arrest and apoptosis in diverse human cancer cell lines and drives regression of human tumor xenografts in nude mice. It shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells. BI 2536 is also an inhibitor of BRD4 (IC50 = 25 nM), suppressing BRD4-dependent c-Myc expression in MM.1S multiple myeloma cells.

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