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ChemicalBook >> CAS DataBase List >> Alpelisib (BYL719)

Alpelisib (BYL719)

$10 - $2691.1
Product name: Alpelisib (BYL719)
CAS: 1217486-61-7
MF: C19H22F3N5O2S
MW: 441.47
EINECS:
MDL Number:MFCD22417085
Synonyms:BYL-719 /BYL719;BLV-719;1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-;(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719;BYL-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide;BYL-719(Alpelisib);(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)-pyridin-4-yl)thiazol-2-yl)pyrrolid;ALPELISIB;BYL-719; BYL 719

Price98 Properties Safety Information Description

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Brand

aablocks
ACHEMBLOCK
Adipogen Life Sciences
AK Scientific
Ambeed
ApexBio Technology
Arctom
AvaChem
Axon Medchem
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
Medical Isotopes, Inc.
Synthonix
TRC
Usbiological

Package

0.05g
0.1g
200mg
0.25g
1000mg
0.5g
10mM(in1mLDMSO)
50.00g
100.00g
10mM*1mLinDMSO
10.00g
005
10mM(in 1mL DMSO)
1unit
1mg
5mg
10mg
20mg
EvaluationSample
25mg
50mg
100mg
250mg
500mg
1g

Manufactureraablocks
Product numberAA0015MQ
Product description(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide ≥98%
Packaging1mg
Price$10
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0015MQ
Product description(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 99%
Packaging5mg
Price$32
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0015MQ
Product description(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 99%
Packaging10mg
Price$46
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0015MQ
Product description(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 99%
Packaging50mg
Price$70
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0015MQ
Product description(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 99%
Packaging250mg
Price$243
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0015MQ
Product description(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 99%
Packaging100mg
Price$111
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0015MQ
Product description(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 99%
Packaging1g
Price$599
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0015MQ
Product description(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
Packaging500mg
Price$397
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberR16000
Product descriptionBYL719 99%
Packaging100MG
Price$95
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberR16000
Product descriptionBYL719 99%
Packaging1G
Price$295
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberR16000
Product descriptionBYL719 99%
Packaging1G
Price$295
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberR16000
Product descriptionBYL719 99%
Packaging100MG
Price$95
Updated2026-05-25
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1230-M001
Product descriptionAlpelisib ≥95%
Packaging1mg
Price$86
Updated2021-12-16
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1230-M001
Product descriptionAlpelisib ≥95%
Packaging1mg
Price$86
Updated2026-05-06
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1230-M005
Product descriptionAlpelisib ≥95%
Packaging5mg
Price$162
Updated2026-05-06
Buy

ManufacturerAdipogen Life Sciences
Product numberSYN-1230-M010
Product descriptionAlpelisib ≥95%
Packaging10mg
Price$238
Updated2026-05-06
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA0015MQ	(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide ≥98%	1mg	$10	2026-05-28	Buy
aablocks	AA0015MQ	(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 99%	5mg	$32	2026-05-28	Buy
aablocks	AA0015MQ	(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 99%	10mg	$46	2026-05-28	Buy
aablocks	AA0015MQ	(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 99%	50mg	$70	2026-05-28	Buy
aablocks	AA0015MQ	(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 99%	250mg	$243	2026-05-28	Buy
aablocks	AA0015MQ	(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 99%	100mg	$111	2026-05-28	Buy
aablocks	AA0015MQ	(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 99%	1g	$599	2026-05-28	Buy
aablocks	AA0015MQ	(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide	500mg	$397	2026-05-28	Buy
ACHEMBLOCK	R16000	BYL719 99%	100MG	$95	2026-05-27	Buy
ACHEMBLOCK	R16000	BYL719 99%	1G	$295	2026-05-25	Buy
ACHEMBLOCK	R16000	BYL719 99%	1G	$295	2026-05-27	Buy
ACHEMBLOCK	R16000	BYL719 99%	100MG	$95	2026-05-25	Buy
Adipogen Life Sciences	SYN-1230-M001	Alpelisib ≥95%	1mg	$86	2021-12-16	Buy
Adipogen Life Sciences	SYN-1230-M001	Alpelisib ≥95%	1mg	$86	2026-05-06	Buy
Adipogen Life Sciences	SYN-1230-M005	Alpelisib ≥95%	5mg	$162	2026-05-06	Buy
Adipogen Life Sciences	SYN-1230-M010	Alpelisib ≥95%	10mg	$238	2026-05-06	Buy

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Properties

Density :1.391
storage temp. :Store at -20°C
solubility :≥22.07 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :White solid.
pka :6.29±0.70(Predicted)
color :Off-white to light yellow
InChIKey :STUWGJZDJHPWGZ-LBPRGKRZSA-N
SMILES :N1(C(NC2=NC(C)=C(C3C=CN=C(C(C)(C)C(F)(F)F)C=3)S2)=O)CCC[C@H]1C(N)=O

Safety Information

Symbol(GHS):

Signal word:

Danger

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H373	May cause damage to organs through prolonged or repeated exposure	Specific target organ toxicity, repeated exposure	Category 2	Warning		P260, P314, P501

Precautionary statements:

P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P314	Get medical advice/attention if you feel unwell.
P501	Dispose of contents/container to..…

Description

BYL719 is a selective inhibitor of phosphoinositide 3-kinase α (PI3Kα) that is equipotent against both wild type and several mutant isoforms (IC50s = 4.0-4.8 nM). It is less effective against PI3K isoforms β, γ, and δ (IC50s = 1,156, 250, and 290 nM) as well as a range of related kinases. BYL719 is effective in vivo, as it dose-dependently inhibits the growth of PI3Kα-dependent xenograft tumors in mice. Effectiveness against wild type and mutant PI3Kα-dependent tumors may be augmented by combination therapy with inhibitors of other kinases. Combination therapy may be necessary, as loss of downstream pathway components can confer clinical resistance to BYL719.

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Suppliers and manufacturers

Wuhan Fortuna Chemical Co., Ltd

Alpelisib CAS:1217486-61-7

Zibo Hangyu Biotechnology Development Co., Ltd

$50.00
Alpelisib (BYL719) CAS:1217486-61-7

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Alpelisib CAS:1217486-61-7

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

$2.00
Alpelisib (BYL719) CAS:1217486-61-7

Hefei Lbao Physical & Chemical Science Co.,Ltd

Alpelisib (BYL719) CAS:1217486-61-7

career henan chemical co

$2.00
(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide CAS:1217486-61-7

TargetMol Chemicals Inc.

$50.00
Alpelisib CAS:1217486-61-7

ATK CHEMICAL COMPANY LIMITED

BOC Sciences

Xi'an Yutbon Pharmaceutical Technology Co., Ltd

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Alpelisib (BYL719)

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