NVP-BEZ 235
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- $12 - $1871.1
- Product name: NVP-BEZ 235
- CAS: 915019-65-7
- MF: C30H23N5O
- MW: 469.55
- EINECS:1312995-182-4
- MDL Number:MFCD10565944
- Synonyms:4-[2,3-Dihydro-3-Methyl-2-oxo-8-(quinolin-3-yl)-1H-iMidazo[4,5-c]quinolin-1-yl]-alpha,alpha-diMethylbenzeneacetonitrile;BEZ-235;2-methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile;2-Methyl-2-[3-Methyl-2-oxo-8-(3-quinolinyl)-1-iMidazo[4,5-c]quinolinyl]propanenitrile;BEZ235 (NVP-BEZ235, Dactolisib);2-Methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl;BEZ235 NVP-BEZ235(BEZ235);2-Methyl-2-[4-[3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile BEZ235(NVP-BEZ235)
91 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO
- 1mg
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 2x50mg
- 100.00mg
- 100mg
- 200mg
- 250.00mg
- 250mg
- 500mg
- 1G
- 1.00g
- 5g
- Manufactureraablocks
- Product numberAA00GRS6
- Product description2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile 98%(HPLC)
- Packaging5mg
- Price$25
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GRS6
- Product description2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile 98+%
- Packaging10mg
- Price$27
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GRS6
- Product description2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile ≥99%
- Packaging25mg
- Price$31
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GRS6
- Product description2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile 98+%
- Packaging50mg
- Price$38
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GRS6
- Product description2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile 98+%
- Packaging1mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GRS6
- Product description2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile 98+%
- Packaging100mg
- Price$61
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GRS6
- Product description2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile
- Packaging200mg
- Price$107
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product number10290
- Product descriptionBEZ235 98%
- Packaging100MG
- Price$113
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10290
- Product descriptionBEZ235 98%
- Packaging25MG
- Price$36
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10290
- Product descriptionBEZ235 98%
- Packaging1G
- Price$504
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3633-M005
- Product descriptionNVP-BEZ235 ≥98%
- Packaging5mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3633-M005
- Product descriptionNVP-BEZ235 ≥98%
- Packaging5mg
- Price$25
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3633-M025
- Product descriptionNVP-BEZ235 ≥98%
- Packaging25mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3633-M025
- Product descriptionNVP-BEZ235 ≥98%
- Packaging25mg
- Price$65
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1018-M050
- Product descriptionBEZ235 ≥95%
- Packaging50mg
- Price$178
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ53044
- Product descriptionDactolisib
- Packaging200mg
- Price$156
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00GRS6 | 2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile 98%(HPLC) | 5mg | $25 | 2026-05-28 | Buy |
| aablocks | AA00GRS6 | 2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile 98+% | 10mg | $27 | 2026-05-28 | Buy |
| aablocks | AA00GRS6 | 2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile ≥99% | 25mg | $31 | 2026-05-28 | Buy |
| aablocks | AA00GRS6 | 2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile 98+% | 50mg | $38 | 2026-05-28 | Buy |
| aablocks | AA00GRS6 | 2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile 98+% | 1mg | $12 | 2026-05-28 | Buy |
| aablocks | AA00GRS6 | 2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile 98+% | 100mg | $61 | 2026-05-28 | Buy |
| aablocks | AA00GRS6 | 2-Methyl-2-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)propanenitrile | 200mg | $107 | 2026-05-28 | Buy |
| ACHEMBLOCK | 10290 | BEZ235 98% | 100MG | $113 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10290 | BEZ235 98% | 25MG | $36 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10290 | BEZ235 98% | 1G | $504 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-3633-M005 | NVP-BEZ235 ≥98% | 5mg | $25 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3633-M005 | NVP-BEZ235 ≥98% | 5mg | $25 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3633-M025 | NVP-BEZ235 ≥98% | 25mg | $65 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3633-M025 | NVP-BEZ235 ≥98% | 25mg | $65 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1018-M050 | BEZ235 ≥95% | 50mg | $178 | 2021-12-16 | Buy |
| AK Scientific | J53044 | Dactolisib | 200mg | $156 | 2021-12-16 | Buy |
Properties
Melting point :288-289°C
Boiling point :701.0±70.0 °C(Predicted)
Density :1.299
storage temp. :Refrigerator
solubility :Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75C).
form :White powder.
pka :6.41±0.20(Predicted)
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month.
InChI :InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
InChIKey :JOGKUKXHTYWRGZ-UHFFFAOYSA-N
SMILES :O=C1N(C2C=NC3=CC=C(C4C=NC5C=CC=CC=5C=4)C=C3C=2N1C1C=CC(C(C)(C)C#N)=CC=1)C
CAS DataBase Reference :915019-65-7
Boiling point :701.0±70.0 °C(Predicted)
Density :1.299
storage temp. :Refrigerator
solubility :Soluble in DMSO (up to 1 mg/ml with warming) or in DMF (up to 10 mg/ml, dissolves slowly, requires heating to 75C).
form :White powder.
pka :6.41±0.20(Predicted)
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 1 month.
InChI :InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3
InChIKey :JOGKUKXHTYWRGZ-UHFFFAOYSA-N
SMILES :O=C1N(C2C=NC3=CC=C(C4C=NC5C=CC=CC=5C=4)C=C3C=2N1C1C=CC(C(C)(C)C#N)=CC=1)C
CAS DataBase Reference :915019-65-7
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. NVP-BEZ235 is a potent dual inhibitor of PI3K and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies. It inhibits PI3K isoforms and mutants with low nanomolar IC50 values, leading to growth arrest in the G1 phase. Through its effects on PI3K, NVP-BEZ235 inhibits VEGF-induced angiogenesis. By directly blocking cell growth and indirectly inhibiting angiogenesis, it has potential in both solid tumors and in metastatic melanoma therapy.More related product prices
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