一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
010-86108875
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook >> CAS DataBase List >> 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione price.
  • $10 - $2839
  • Product name: 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione
  • CAS: 425637-18-9
  • MF: C25H22N6O2
  • MW: 438.48
  • EINECS:
  • MDL Number:MFCD16038049
  • Synonyms:3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione;Sotrastaurin (AEB071);3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione;Sotrastaurin - AEB 071 | NVP-AEB 071;CS-1479;AEB071; AEB 071; AEB-071;1H-benzo[d][1,2,3]triazol-5-ol;1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[2-(4-methyl-1-piperazinyl)-4-quinazolinyl]-
71 prices
Selected condition:
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 2mg
  • 10mM*1mLinDMSO
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 2x25mg
  • 50mg
  • 100mg
  • 10mM(in1mLDMSO)
  • 250mg
  • 1G
  • 1000mg
  • 10mM(in 1mL DMSO)
  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione ≥98%
  • Packaging1mg
  • Price$10
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione ≥98%
  • Packaging5mg
  • Price$18
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+%
  • Packaging10mg
  • Price$33
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+%
  • Packaging25mg
  • Price$51
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+%
  • Packaging50mg
  • Price$86
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+%
  • Packaging100mg
  • Price$137
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00C0UE
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+%
  • Packaging250mg
  • Price$221
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10385
  • Product descriptionSotrastaurin 98%
  • Packaging100MG
  • Price$145
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10385
  • Product descriptionSotrastaurin 98%
  • Packaging25MG
  • Price$50
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10385
  • Product descriptionSotrastaurin 98%
  • Packaging1G
  • Price$850
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product numberY6229
  • Product description3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione
  • Packaging250mg
  • Price$327
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0014152
  • Product descriptionSOTRASTAURIN 95.00%
  • Packaging1MG
  • Price$430
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0014152
  • Product descriptionSOTRASTAURIN 95.00%
  • Packaging5MG
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0014152
  • Product descriptionSOTRASTAURIN 95.00%
  • Packaging10MG
  • Price$700
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8525
  • Product descriptionSotrastaurin (AEB071)
  • Packaging50mg
  • Price$935
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8525
  • Product descriptionSotrastaurin(AEB071)
  • Packaging50mg
  • Price$850
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione ≥98% 1mg $10 2026-05-28 Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione ≥98% 5mg $18 2026-05-28 Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+% 10mg $33 2026-05-28 Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+% 25mg $51 2026-05-28 Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+% 50mg $86 2026-05-28 Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+% 100mg $137 2026-05-28 Buy
aablocks AA00C0UE 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 98+% 250mg $221 2026-05-28 Buy
ACHEMBLOCK 10385 Sotrastaurin 98% 100MG $145 2026-05-27 Buy
ACHEMBLOCK 10385 Sotrastaurin 98% 25MG $50 2026-05-27 Buy
ACHEMBLOCK 10385 Sotrastaurin 98% 1G $850 2026-05-27 Buy
AK Scientific Y6229 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione 250mg $327 2021-12-16 Buy
American Custom Chemicals Corporation API0014152 SOTRASTAURIN 95.00% 1MG $430 2021-12-16 Buy
American Custom Chemicals Corporation API0014152 SOTRASTAURIN 95.00% 5MG $550 2021-12-16 Buy
American Custom Chemicals Corporation API0014152 SOTRASTAURIN 95.00% 10MG $700 2021-12-16 Buy
ApexBio Technology A8525 Sotrastaurin (AEB071) 50mg $935 2026-05-06 Buy
ApexBio Technology A8525 Sotrastaurin(AEB071) 50mg $850 2021-12-16 Buy

Properties

Density :1.406
storage temp. :Store at -20°C
solubility :≥21.9 mg/mL in DMSO; insoluble in H2O; ≥2.55 mg/mL in EtOH with ultrasonic
form :solid
pka :7.39±0.60(Predicted)
color :Pink to red
InChI :1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
InChIKey :OAVGBZOFDPFGPJ-UHFFFAOYSA-N
SMILES :N1C(=O)C(C2=C3C(=NC(N4CCN(C)CC4)=N2)C=CC=C3)=C(C2C3=C(NC=2)C=CC=C3)C1=O

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Sotrastaurin is a protein kinase C (PKC) inhibitor that displays immunosuppressive activity, blocking T cell activation through the disruption of downstream NF-κB signaling. In cell-free assays, sotrastaurin was reported to inhibit PKCα, βI, δ, ε, η, and θ with Ki values of 0.95, 0.64, 2.1, 3.2, 1.8, and 0.22 nM, respectively. Sotrastaurin can prevent the production of various cytokines by activated T cells, macrophages, and keratinocytes in vitro and has been shown to inhibit an acute allergic contact dermatitis response in rats when dosed orally at 30 mg. However, clinical investigation of sotrastaurin for its potential to prevent renal transplant rejection was halted during phase II testing due to high incidence of rejection. Sotrastaurin is also reported to activate Wnt/β-catenin signaling via the inhibition of glycogen synthase kinase 3 (IC50s = 229 and 172 nM for α and β isoforms, respectively), which is essential for embryogenesis and adult stem cell maintenance.

Related product price

台中市| 玛纳斯县| 芮城县| 甘孜| 新安县| 康定县| 聂荣县| 墨江| 喀喇沁旗| 镇赉县| 滁州市| 赣州市| 黄山市| 营口市| 怀安县| 贵州省| 咸丰县| 垣曲县| 临桂县| 中山市| 浦东新区| 莫力| 洛浦县| 大关县| 尉氏县| 蛟河市| 华池县| 龙陵县| 济南市| 西城区| 桦川县| 镇雄县| 平山县| 富宁县| 平阴县| 凭祥市| 高雄市| 牙克石市| 崇州市| 苏尼特右旗| 赣州市|