(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
![(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol price.](/CAS/GIF/779353-01-4.gif)
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- $28 - $3728.1
- Product name: (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
- CAS: 779353-01-4
- MF: C21H28N6O2
- MW: 396.49
- EINECS:214-589-6
- MDL Number:MFCD16037702
- Synonyms:(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Dinaciclib (SCH727965);2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-, (2S)-;Dinaciclib, >=98%;DINACICLIB (SCH727965);SCH 727965;(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol;(S)-3-(((3-Ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methy;PS-095760;(S)-3-((3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyriMidin-7-ylaMino)Methyl)pyridine 1-oxide
88 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Medical Isotopes, Inc.
- Tocris
- TRC
- Usbiological
Package
- EvaluationSample
- 10mM(in 1mL DMSO)
- 10mM(in1mLDMSO)
- 1unit
- 10mM*1mLinDMSO
- 10
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1G
- 1000mg
- Manufactureraablocks
- Product numberAA003AH9
- Product description(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 98%
- Packaging1mg
- Price$33
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003AH9
- Product description(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 98%
- Packaging10mg
- Price$83
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003AH9
- Product description(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 98%
- Packaging5mg
- Price$52
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003AH9
- Product description(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 95%
- Packaging25mg
- Price$202
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003AH9
- Product description(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 98%
- Packaging50mg
- Price$271
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003AH9
- Product description(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 98%
- Packaging100mg
- Price$384
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003AH9
- Product description(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 98%
- Packaging250mg
- Price$958
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51693
- Product descriptionDinaciclib 98%
- Packaging100MG
- Price$490
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51693
- Product descriptionDinaciclib 98%
- Packaging25MG
- Price$185
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51693
- Product descriptionDinaciclib 98%
- Packaging5MG
- Price$70
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51693
- Product descriptionDinaciclib 98%
- Packaging1G
- Price$1650
- Updated2026-05-27
- Buy
- ManufacturerAmbeed
- Product numberA196584
- Product descriptionDinaciclib 98%
- Packaging250mg
- Price$1212
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA196584
- Product descriptionDinaciclib 98%
- Packaging1g
- Price$3532
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA196584
- Product descriptionDinaciclib 98%
- Packaging100mg
- Price$485
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA196584
- Product descriptionDinaciclib 98%
- Packaging5mg
- Price$65
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA196584
- Product descriptionDinaciclib 98%
- Packaging1mg
- Price$41
- Updated2026-06-05
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA003AH9 | (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 98% | 1mg | $33 | 2026-05-28 | Buy |
| aablocks | AA003AH9 | (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 98% | 10mg | $83 | 2026-05-28 | Buy |
| aablocks | AA003AH9 | (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 98% | 5mg | $52 | 2026-05-28 | Buy |
| aablocks | AA003AH9 | (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 95% | 25mg | $202 | 2026-05-28 | Buy |
| aablocks | AA003AH9 | (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 98% | 50mg | $271 | 2026-05-28 | Buy |
| aablocks | AA003AH9 | (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 98% | 100mg | $384 | 2026-05-28 | Buy |
| aablocks | AA003AH9 | (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol 98% | 250mg | $958 | 2026-05-28 | Buy |
| ACHEMBLOCK | P51693 | Dinaciclib 98% | 100MG | $490 | 2026-05-27 | Buy |
| ACHEMBLOCK | P51693 | Dinaciclib 98% | 25MG | $185 | 2026-05-27 | Buy |
| ACHEMBLOCK | P51693 | Dinaciclib 98% | 5MG | $70 | 2026-05-27 | Buy |
| ACHEMBLOCK | P51693 | Dinaciclib 98% | 1G | $1650 | 2026-05-27 | Buy |
| Ambeed | A196584 | Dinaciclib 98% | 250mg | $1212 | 2026-06-05 | Buy |
| Ambeed | A196584 | Dinaciclib 98% | 1g | $3532 | 2026-06-05 | Buy |
| Ambeed | A196584 | Dinaciclib 98% | 100mg | $485 | 2026-06-05 | Buy |
| Ambeed | A196584 | Dinaciclib 98% | 5mg | $65 | 2026-06-05 | Buy |
| Ambeed | A196584 | Dinaciclib 98% | 1mg | $41 | 2026-06-05 | Buy |
Properties
Melting point :>78oC (dec.)
Density :1.33
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :15.15±0.10(Predicted)
form :Solid
color :White to Light Beige
Stability :Hygroscopic
InChIKey :PIMQWRZWLQKKBJ-SFHVURJKSA-N
SMILES :N1(C2C=C(NCC3C=CC=[N+]([O-])C=3)N3N=CC(CC)=C3N=2)CCCC[C@H]1CCO
CAS DataBase Reference :779353-01-4
Density :1.33
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :15.15±0.10(Predicted)
form :Solid
color :White to Light Beige
Stability :Hygroscopic
InChIKey :PIMQWRZWLQKKBJ-SFHVURJKSA-N
SMILES :N1(C2C=C(NCC3C=CC=[N+]([O-])C=3)N3N=CC(CC)=C3N=2)CCCC[C@H]1CCO
CAS DataBase Reference :779353-01-4
Safety Information
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Description
Cyclin-dependent kinases (CDKs) are critical positive regulators of cell cycle progression and cellular transcription whose dysregulation can lead to the development of cancer. Dinaciclib inhibits CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC50 values of 3, 1, 1, and 4 nM, respectively. Compared to the pan-CDK inhibitor flavopiridol , dinaciclib is an equally potent inhibitor of CDK1 and CDK9 but a 12-14-fold more potent inhibitor of CDK2 and CDK5. It has been shown to inhibit DNA synthesis by blocking thymidine incorporation in A2780 ovarian cancer cells with an IC50 value of 4 nM. At 5 mg/kg it prevents tumor growth by 50% in an A2780 ovarian carcinoma mouse xenograft model and is active against a broad spectrum of human tumor cell lines in vitro (IC50s = 7-17 nM).More related product prices
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![(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol](https://img.chemicalbook.com/ProductImageEN/2019-7/small/a5b4d703-7dc0-4232-9cae-87441080794d.png){kind=small}
![(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol](/ProductImageEN/2021-04/small/236f30b8-faec-456a-b187-a54cb47af23c.png){kind=small}