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ChemicalBook >> CAS DataBase List >> Pyrazinecarboxamide, 3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]- (9CI)

Pyrazinecarboxamide, 3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]- (9CI)

Pyrazinecarboxamide, 3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]- (9CI)
 price.
  • $156 - $2800
  • Product name: Pyrazinecarboxamide, 3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]- (9CI)
  • CAS: 906805-42-3
  • MF: C23H31Cl2N7O
  • MW: 492.44
  • EINECS:
  • MDL Number:MFCD11042275
  • Synonyms:Pyrazinecarboxamide, 3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]- (9CI) ;2-Pyrazinecarboxamide, 3-amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-;3-aMino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)Methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-;SCH 546738 (free base);SCH 546738;(S)-3-Amino-6-chloro-5-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpiperazin-1-yl)pyrazine-2-car;3-Amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]pyrazinecarboxamide;(S)-3-Amino-6-chloro-5-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpiperazin-1-yl)pyrazine-2-
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  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
  • Usbiological
Package
  • 500ug
  • 1MG
  • 2.5mg
  • 5mg
  • 10mg
  • 25mg
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  • 100mg
  • 250mg
  • 1.00g
  • 1g
  • Manufactureraablocks
  • Product numberAA006B1O
  • Product description3-Amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide >98%
  • Packaging5mg
  • Price$391
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006B1O
  • Product description3-Amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide >98%
  • Packaging10mg
  • Price$547
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006B1O
  • Product description3-Amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide >98%
  • Packaging25mg
  • Price$869
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA006B1O
  • Product description3-Amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide >98%
  • Packaging50mg
  • Price$1258
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA006B1O
  • Product description3-Amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide >98%
  • Packaging100mg
  • Price$1702
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberAD264368
  • Product descriptionSCH 546738 98%
  • Packaging25MG
  • Price$1085
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberAD264368
  • Product descriptionSCH 546738 98%
  • Packaging5MG
  • Price$460
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberAD264368
  • Product descriptionSCH 546738 98%
  • Packaging1MG
  • Price$165
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product number5102AC
  • Product description(S)-3-Amino-6-chloro-5-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpiperazin-1-yl)pyrazine-2-carboxamide
  • Packaging250mg
  • Price$1275
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number5102AC
  • Product description(S)-3-Amino-6-chloro-5-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpiperazin-1-yl)pyrazine-2-carboxamide
  • Packaging1g
  • Price$2771
  • Updated2021-12-16
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  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberHCH0106210
  • Product description3-AMINO-6-CHLORO-5-[(3S)-4-[1-[(4-CHLOROPHENYL)METHYL]-4-PIPERIDINYL]-3-ETHYL-1-PYRAZINECARBOXAMIDE 95.00%
  • Packaging5MG
  • Price$498.64
  • Updated2021-12-16
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  • ManufacturerCayman Chemical
  • Product number28447
  • Product descriptionSCH 546738 ≥95%
  • Packaging25mg
  • Price$767
  • Updated2026-04-30
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  • ManufacturerCayman Chemical
  • Product number28447
  • Product descriptionSCH 546738 ≥95%
  • Packaging50mg
  • Price$986
  • Updated2026-04-30
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  • ManufacturerCayman Chemical
  • Product number28447
  • Product descriptionSCH 546738 ≥95%
  • Packaging5mg
  • Price$219
  • Updated2026-04-30
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  • ManufacturerCayman Chemical
  • Product number28447
  • Product descriptionSCH 546738 ≥95%
  • Packaging10mg
  • Price$350
  • Updated2026-04-30
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  • ManufacturerChemScene
  • Product numberCS-1978
  • Product descriptionSCH 546738 98.67%
  • Packaging5mg
  • Price$347
  • Updated2026-06-04
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA006B1O 3-Amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide >98% 5mg $391 2026-05-28 Buy
aablocks AA006B1O 3-Amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide >98% 10mg $547 2026-05-28 Buy
aablocks AA006B1O 3-Amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide >98% 25mg $869 2026-05-28 Buy
aablocks AA006B1O 3-Amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide >98% 50mg $1258 2026-05-28 Buy
aablocks AA006B1O 3-Amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-3-ethylpiperazin-1-yl]pyrazine-2-carboxamide >98% 100mg $1702 2026-05-28 Buy
ACHEMBLOCK AD264368 SCH 546738 98% 25MG $1085 2026-05-27 Buy
ACHEMBLOCK AD264368 SCH 546738 98% 5MG $460 2026-05-27 Buy
ACHEMBLOCK AD264368 SCH 546738 98% 1MG $165 2026-05-27 Buy
AK Scientific 5102AC (S)-3-Amino-6-chloro-5-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpiperazin-1-yl)pyrazine-2-carboxamide 250mg $1275 2021-12-16 Buy
AK Scientific 5102AC (S)-3-Amino-6-chloro-5-(4-(1-(4-chlorobenzyl)piperidin-4-yl)-3-ethylpiperazin-1-yl)pyrazine-2-carboxamide 1g $2771 2021-12-16 Buy
American Custom Chemicals Corporation HCH0106210 3-AMINO-6-CHLORO-5-[(3S)-4-[1-[(4-CHLOROPHENYL)METHYL]-4-PIPERIDINYL]-3-ETHYL-1-PYRAZINECARBOXAMIDE 95.00% 5MG $498.64 2021-12-16 Buy
Cayman Chemical 28447 SCH 546738 ≥95% 25mg $767 2026-04-30 Buy
Cayman Chemical 28447 SCH 546738 ≥95% 50mg $986 2026-04-30 Buy
Cayman Chemical 28447 SCH 546738 ≥95% 5mg $219 2026-04-30 Buy
Cayman Chemical 28447 SCH 546738 ≥95% 10mg $350 2026-04-30 Buy
ChemScene CS-1978 SCH 546738 98.67% 5mg $347 2026-06-04 Buy

Properties

Boiling point :628.2±55.0 °C(Predicted)
Density :1.326±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 4.5 mg/mL (9.14 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form :Powder
pka :14.24±0.50(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

3-Amino-6-chloro-5-[(3S)-4-[1-[(4-chlorophenyl)methyl]-4-piperidinyl]-3-ethyl-1-piperazinyl]-2-pyrazinecarboxamide is a potent and non-competitive small molecule CXCR3 antagonist. It was reported that therapy with CXCR3 antagonists may serve as a new strategy for treatment of autoimmune diseases.

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