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ChemicalBook >> CAS DataBase List >> ALK5 inhibitor II

ALK5 inhibitor II

ALK5 inhibitor II price.
  • $10 - $4788
  • Product name: ALK5 inhibitor II
  • CAS: 446859-33-2
  • MF: C17H13N5
  • MW: 287.32
  • EINECS:
  • MDL Number:MFCD09037561
  • Synonyms:ALK5 INHIBITOR I;2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE;2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine;SJN 2511;2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine;E 616452;1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-;RepSox 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
93 prices
Selected condition:
Brand
  • aablocks
  • ACHEMBLOCK
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10mM*1mLinDMSO(Solution)
  • 2mg
  • 10mM(1mLinDMSO)
  • 5mg
  • 10
  • 50
  • 1000mg
  • 10mM*1mLinDMSO
  • 10mM(in1mLDMSO)
  • 1mg
  • 10mg
  • 25MG
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 5g
  • 10mM(in 1mL DMSO)
  • Manufactureraablocks
  • Product numberAA00DEDG
  • Product descriptionRepSox 98%
  • Packaging1mg
  • Price$10
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEDG
  • Product descriptionRepSox 98%
  • Packaging50mg
  • Price$32
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEDG
  • Product descriptionRepSox 98%
  • Packaging100mg
  • Price$53
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEDG
  • Product descriptionRepSox 98%
  • Packaging250mg
  • Price$87
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEDG
  • Product descriptionRepSox 98%
  • Packaging1g
  • Price$234
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEDG
  • Product descriptionRepSox 96%
  • Packaging5g
  • Price$1153
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10369
  • Product descriptionRepSox 98%
  • Packaging1G
  • Price$780
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10369
  • Product descriptionRepSox 98%
  • Packaging100MG
  • Price$260
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10369
  • Product descriptionRepSox 98%
  • Packaging25MG
  • Price$90
  • Updated2026-05-27
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3754
  • Product descriptionRepSox
  • Packaging10mM(in 1mL DMSO)
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3754
  • Product descriptionRepSox
  • Packaging10mg
  • Price$99
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3754
  • Product descriptionRepSox
  • Packaging10mM(in1mLDMSO)
  • Price$105
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3754
  • Product descriptionRepSox
  • Packaging25mg
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3754
  • Product descriptionRepSox
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3754
  • Product descriptionRepSox
  • Packaging25mg
  • Price$182
  • Updated2026-05-06
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S7223
  • Product descriptionRepSox (E-616452) 99.92%
  • Packaging10mM(1mLinDMSO)
  • Price$188
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00DEDG RepSox 98% 1mg $10 2026-05-28 Buy
aablocks AA00DEDG RepSox 98% 50mg $32 2026-05-28 Buy
aablocks AA00DEDG RepSox 98% 100mg $53 2026-05-28 Buy
aablocks AA00DEDG RepSox 98% 250mg $87 2026-05-28 Buy
aablocks AA00DEDG RepSox 98% 1g $234 2026-05-28 Buy
aablocks AA00DEDG RepSox 96% 5g $1153 2026-05-28 Buy
ACHEMBLOCK 10369 RepSox 98% 1G $780 2026-05-27 Buy
ACHEMBLOCK 10369 RepSox 98% 100MG $260 2026-05-27 Buy
ACHEMBLOCK 10369 RepSox 98% 25MG $90 2026-05-27 Buy
ApexBio Technology A3754 RepSox 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A3754 RepSox 10mg $99 2026-05-06 Buy
ApexBio Technology A3754 RepSox 10mM(in1mLDMSO) $105 2026-05-06 Buy
ApexBio Technology A3754 RepSox 25mg $165 2021-12-16 Buy
ApexBio Technology A3754 RepSox 10mg $90 2021-12-16 Buy
ApexBio Technology A3754 RepSox 25mg $182 2026-05-06 Buy
Arctom SLK-S7223 RepSox (E-616452) 99.92% 10mM(1mLinDMSO) $188 2026-05-26 Buy

Properties

Melting point :195 °C
Boiling point :501.9±50.0 °C(Predicted)
Density :1.296±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
form :Yellow solid
pka :10.05±0.50(Predicted)
color :Pale yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
InChIKey :LBPKYPYHDKKRFS-UHFFFAOYSA-N
SMILES :N1C2C(=NC=CC=2)C=CC=1C1=CNN=C1C1=NC(C)=CC=C1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

ALK5 inhibitor II is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.

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