AVN-944
|
- $38 - $3120
- Product name: AVN-944
- CAS: 297730-17-7
- MF: C25H27N5O5
- MW: 477.51
- EINECS:
- MDL Number:
- Synonyms:VX 944;VX944;VX-944;AVN944 (VX-944);(R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate;VX 944; AVN-944;;CS-1604;[(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate
50 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Cayman Chemical
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 10mM*1mLinDMSO(Solution)
- 5mg
- 10mg
- 25mg
- 10mM*1mLinDMSO
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- 1mL(10mMinDMSO)
- Manufactureraablocks
- Product numberAA00BF2S
- Product description(R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97
- Packaging1mg
- Price$64
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF2S
- Product description(R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97
- Packaging5mg
- Price$92
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF2S
- Product description(R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97
- Packaging10mg
- Price$132
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF2S
- Product description(R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97
- Packaging25mg
- Price$238
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF2S
- Product description(R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 99%
- Packaging50mg
- Price$273
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF2S
- Product description(R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97%
- Packaging100mg
- Price$452
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF2S
- Product description(R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97
- Packaging200mg
- Price$699
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF2S
- Product description(R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97%
- Packaging1g
- Price$3120
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberT99316
- Product description(R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate 98%
- Packaging100MG
- Price$705
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberT99316
- Product description(R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate 98%
- Packaging100MG
- Price$705
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberT99316
- Product description(R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate 98%
- Packaging25MG
- Price$235
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberT99316
- Product description(R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate 98%
- Packaging25MG
- Price$235
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number4211CR
- Product descriptionAvn-944
- Packaging1mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberBA1210
- Product descriptionAVN-944
- Packaging10mg
- Price$153
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberBA1210
- Product descriptionAVN-944
- Packaging1mL(10mMinDMSO)
- Price$108
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberBA1210
- Product descriptionAVN-944
- Packaging5mg
- Price$99
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00BF2S | (R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97 | 1mg | $64 | 2026-05-28 | Buy |
| aablocks | AA00BF2S | (R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97 | 5mg | $92 | 2026-05-28 | Buy |
| aablocks | AA00BF2S | (R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97 | 10mg | $132 | 2026-05-28 | Buy |
| aablocks | AA00BF2S | (R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97 | 25mg | $238 | 2026-05-28 | Buy |
| aablocks | AA00BF2S | (R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 99% | 50mg | $273 | 2026-05-28 | Buy |
| aablocks | AA00BF2S | (R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97% | 100mg | $452 | 2026-05-28 | Buy |
| aablocks | AA00BF2S | (R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97 | 200mg | $699 | 2026-05-28 | Buy |
| aablocks | AA00BF2S | (R)-1-Cyanobutan-2-yl ((S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethyl)carbamate 97% | 1g | $3120 | 2026-05-28 | Buy |
| ACHEMBLOCK | T99316 | (R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate 98% | 100MG | $705 | 2026-05-25 | Buy |
| ACHEMBLOCK | T99316 | (R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate 98% | 100MG | $705 | 2026-05-27 | Buy |
| ACHEMBLOCK | T99316 | (R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate 98% | 25MG | $235 | 2026-05-25 | Buy |
| ACHEMBLOCK | T99316 | (R)-1-cyanobutan-2-yl (S)-1-(3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)phenyl)ethylcarbamate 98% | 25MG | $235 | 2026-05-27 | Buy |
| AK Scientific | 4211CR | Avn-944 | 1mg | $140 | 2021-12-16 | Buy |
| ApexBio Technology | BA1210 | AVN-944 | 10mg | $153 | 2026-05-06 | Buy |
| ApexBio Technology | BA1210 | AVN-944 | 1mL(10mMinDMSO) | $108 | 2026-05-06 | Buy |
| ApexBio Technology | BA1210 | AVN-944 | 5mg | $99 | 2026-05-06 | Buy |
Properties
Boiling point :597.4±50.0 °C(Predicted)
Density :1.277±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.52(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);62.83(Max Conc. mM) form :A crystalline solid
pka :11.38±0.46(Predicted)
color :White to off-white
InChIKey :GYCPCOJTCINIFZ-OXJNMPFZSA-N
SMILES :N([C@@H](C)c1cc(ccc1)NC(=O)Nc2cc(c(cc2)c3[o]cnc3)OC)C(=O)O[C@H](CC)CC#N
Density :1.277±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.52(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);62.83(Max Conc. mM) form :A crystalline solid
pka :11.38±0.46(Predicted)
color :White to off-white
InChIKey :GYCPCOJTCINIFZ-OXJNMPFZSA-N
SMILES :N([C@@H](C)c1cc(ccc1)NC(=O)Nc2cc(c(cc2)c3[o]cnc3)OC)C(=O)O[C@H](CC)CC#N
Safety Information
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Description
AVN944 is a selective, noncompetitive inhibitor of inosine-5''-monophosphate dehydrogenase (IMPDH; Ki = 6-10 nM for both human IMPDH isoforms), a rate-limiting enzyme involved in the de novo synthesis of purine nucleotides. Inhibition of IMPDH results in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 has been shown to inhibit the proliferation of multiple myeloma cells in vitro by inducing caspase-independent apoptosis. It is also reported to have antitumor properties in androgen-sensitive and androgen-independent prostate cancer cells in vitro.Related product price
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Suppliers and manufacturers
BOC Sciences
Zhejiang J&C Biological Technology Co.,Limited
HANGZHOU LEAP CHEM CO., LTD.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Zibo Hangyu Biotechnology Development Co., Ltd
Aladdin Scientific
Amadis Chemical Company Limited
Shanghai Boyle Chemical Co., Ltd.
![[(2R)-1-cyanobutan-2-yl] N-[(1S)-1-[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]ethyl]carbamate](https://img.chemicalbook.com/ProductImageEN/2020-1/small/000a41f5-0222-4479-966f-aed4abf409ce.png){kind=small}
