BH3I-1
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- $32 - $2439
- Product name: BH3I-1
- CAS: 300817-68-9
- MF: C15H14BrNO3S2
- MW: 400.31
- EINECS:
- MDL Number:MFCD03453544
- Synonyms:5-(p-Bromobenzylidine)-α-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid;BH3I 1 ;BH3I1;BHI1;BHI1;BH 3I1;3-Thiazolidineacetic acid, 5-[(4-bromophenyl)methylene]-α-(1-methylethyl)-4-oxo-2-thioxo-;5-(p-Bromobenzylidene)-a-isopropyl-4-oxo-2-thioxo-3-thiazolidine acetic acid;2-(5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-methylbutanoic acid;MDM-2/p53,BH3I 1,Inhibitor,Ubiquitin ligase,BH3I-1,E3 ligating enzyme,Ubiquitin conjugating enzyme,BH3I1,E2 conjugating enzyme,Bcl-2 Family,BHI 1,E1 activating enzyme,inhibit,BHI-1,BH 3I1,E1/E2/E3 Enzyme,Ubiquitin activating enzyme,BH-3I-1
58 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 1G
- Manufactureraablocks
- Product numberAA00BF4G
- Product descriptionBH3I-1 99%
- Packaging10mg
- Price$61
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF4G
- Product descriptionBH3I-1 99%
- Packaging25mg
- Price$102
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF4G
- Product descriptionBH3I-1 99%
- Packaging5mg
- Price$38
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00BF4G
- Product descriptionBH3I-1 99%
- Packaging2mg
- Price$32
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15360
- Product descriptionBH3I-1 98%
- Packaging1G
- Price$730
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15360
- Product descriptionBH3I-1 98%
- Packaging100MG
- Price$230
- Updated2026-05-27
- Buy
- ManufacturerAmbeed
- Product numberA189286
- Product descriptionBH3I-1 98+%
- Packaging25mg
- Price$340
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189286
- Product descriptionBH3I-1 98+%
- Packaging5mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189286
- Product descriptionBH3I-1 98+%
- Packaging10mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189286
- Product descriptionBH3I-1 98+%
- Packaging50mg
- Price$442
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008455
- Product descriptionBH3I-1 95.00%
- Packaging5MG
- Price$750.87
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6094
- Product descriptionBH3I-1
- Packaging10mg
- Price$111
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6094
- Product descriptionBH3I-1
- Packaging2mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6094
- Product descriptionBH3I-1
- Packaging5mg
- Price$72
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6094
- Product descriptionBH3I-1
- Packaging2mg
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6094
- Product descriptionBH3I-1
- Packaging25mg
- Price$215
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00BF4G | BH3I-1 99% | 10mg | $61 | 2026-05-28 | Buy |
| aablocks | AA00BF4G | BH3I-1 99% | 25mg | $102 | 2026-05-28 | Buy |
| aablocks | AA00BF4G | BH3I-1 99% | 5mg | $38 | 2026-05-28 | Buy |
| aablocks | AA00BF4G | BH3I-1 99% | 2mg | $32 | 2026-05-28 | Buy |
| ACHEMBLOCK | M15360 | BH3I-1 98% | 1G | $730 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15360 | BH3I-1 98% | 100MG | $230 | 2026-05-27 | Buy |
| Ambeed | A189286 | BH3I-1 98+% | 25mg | $340 | 2021-12-16 | Buy |
| Ambeed | A189286 | BH3I-1 98+% | 5mg | $118 | 2021-12-16 | Buy |
| Ambeed | A189286 | BH3I-1 98+% | 10mg | $200 | 2021-12-16 | Buy |
| Ambeed | A189286 | BH3I-1 98+% | 50mg | $442 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008455 | BH3I-1 95.00% | 5MG | $750.87 | 2021-12-16 | Buy |
| ApexBio Technology | B6094 | BH3I-1 | 10mg | $111 | 2026-05-06 | Buy |
| ApexBio Technology | B6094 | BH3I-1 | 2mg | $65 | 2021-12-16 | Buy |
| ApexBio Technology | B6094 | BH3I-1 | 5mg | $72 | 2026-05-06 | Buy |
| ApexBio Technology | B6094 | BH3I-1 | 2mg | $55 | 2026-05-06 | Buy |
| ApexBio Technology | B6094 | BH3I-1 | 25mg | $215 | 2026-05-06 | Buy |
Properties
Boiling point :535.2±60.0 °C(Predicted)
Density :1+-.0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: >10 mg/mL, soluble
form :powder, yellow
pka :3.39±0.10(Predicted)
color :Light yellow to yellow
InChI :1S/C15H14BrNO3S2/c1-8(2)12(14(19)20)17-13(18)11(22-15(17)21)7-9-3-5-10(16)6-4-9/h3-8,12H,1-2H3,(H,19,20)/b11-7+
InChIKey :COHIEJLWRGREHV-YRNVUSSQSA-N
SMILES :CC(C)C(N1C(=S)S\C(=C\c2ccc(Br)cc2)C1=O)C(O)=O
Density :1+-.0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: >10 mg/mL, soluble
form :powder, yellow
pka :3.39±0.10(Predicted)
color :Light yellow to yellow
InChI :1S/C15H14BrNO3S2/c1-8(2)12(14(19)20)17-13(18)11(22-15(17)21)7-9-3-5-10(16)6-4-9/h3-8,12H,1-2H3,(H,19,20)/b11-7+
InChIKey :COHIEJLWRGREHV-YRNVUSSQSA-N
SMILES :CC(C)C(N1C(=S)S\C(=C\c2ccc(Br)cc2)C1=O)C(O)=O
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||
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Description
The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains. BH3I-1 is a cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis. It inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki values of 43.4 and 124 μM, respectively. BH3I-1 enhances radiation sensitivity in non-small cell lung cancer cells.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
BOC Sciences
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific
