BH3I-1
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1物価
選択條件：
ブランド
- Sigma-Aldrich Japan
パッケージ
- 5mg
- 生産者Sigma-Aldrich Japan
- 製品番號(hào)B8809
- 製品説明 ≥97% (HPLC), powder, yellow
- 英語製品説明BH3I-1 ≥97% (HPLC), powder, yellow
- 包裝単位5mg
- 価格￥38800
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番號(hào) | 製品説明 | 包裝単位 | 価格 | 更新時(shí)間 | 購入 |
|---|---|---|---|---|---|---|
| Sigma-Aldrich Japan | B8809 | ≥97% (HPLC), powder, yellow BH3I-1 ≥97% (HPLC), powder, yellow |
5mg | ￥38800 | 2024-03-01 | 購入 |
プロパティ
沸點(diǎn) :535.2±60.0 °C(Predicted)
比重(密度) :1+-.0.1 g/cm3(Predicted)
貯蔵溫度 :Sealed in dry,2-8°C
溶解性 :DMSO: >10 mg/mL, soluble
外見 :powder, yellow
酸解離定數(shù)(Pka) :3.39±0.10(Predicted)
色 :Light yellow to yellow
InChI :1S/C15H14BrNO3S2/c1-8(2)12(14(19)20)17-13(18)11(22-15(17)21)7-9-3-5-10(16)6-4-9/h3-8,12H,1-2H3,(H,19,20)/b11-7+
InChIKey :COHIEJLWRGREHV-YRNVUSSQSA-N
SMILES :CC(C)C(N1C(=S)S\C(=C\c2ccc(Br)cc2)C1=O)C(O)=O
比重(密度) :1+-.0.1 g/cm3(Predicted)
貯蔵溫度 :Sealed in dry,2-8°C
溶解性 :DMSO: >10 mg/mL, soluble
外見 :powder, yellow
酸解離定數(shù)(Pka) :3.39±0.10(Predicted)
色 :Light yellow to yellow
InChI :1S/C15H14BrNO3S2/c1-8(2)12(14(19)20)17-13(18)11(22-15(17)21)7-9-3-5-10(16)6-4-9/h3-8,12H,1-2H3,(H,19,20)/b11-7+
InChIKey :COHIEJLWRGREHV-YRNVUSSQSA-N
SMILES :CC(C)C(N1C(=S)S\C(=C\c2ccc(Br)cc2)C1=O)C(O)=O
安全情報(bào)
| 絵表示(GHS): |
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| 注意喚起語: | Warning | ||||||||||
| 危険有害性情報(bào): |
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| 注意書き: |
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説明
The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains. BH3I-1 is a cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis. It inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki values of 43.4 and 124 μM, respectively. BH3I-1 enhances radiation sensitivity in non-small cell lung cancer cells.供給者とメーカー
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