BIO
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- $10 - $1440
- Product name: BIO
- CAS: 667463-62-9
- MF: C16H10BrN3O2
- MW: 356.17
- EINECS:
- MDL Number:MFCD08705318
- Synonyms:2H-Indol-2-one, 6-broMo-3-[(3E)-1,3-dihydro-3-(hydroxyiMino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-;6BIO;6-bromoindirubin-3-oxime;GSK3 Inhibitor IX1;BIO(GSK-3 Inhibitor IX;BIO (SM04554);InSolution? GSK-3 Inhibitor IX ;(2E,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one
84 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TCI Chemical
- Thermo Scientific Chemicals
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM(in1mLDMSO)
- 10mM*1mLinDMSO
- 1mg
- 30mg
- 250mg
- 10mM(in 1mL DMSO)
- 500μg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1G
- Manufactureraablocks
- Product numberAA00FBFK
- Product descriptionBIO 98%
- Packaging1mg
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBFK
- Product descriptionBIO 98
- Packaging25mg
- Price$212
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBFK
- Product descriptionBIO 98
- Packaging50mg
- Price$367
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBFK
- Product descriptionBIO 98
- Packaging100mg
- Price$534
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22580
- Product descriptionGSK-3 Inhibitor IX 98%
- Packaging100MG
- Price$165
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22580
- Product descriptionGSK-3 Inhibitor IX 98%
- Packaging1G
- Price$815
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-MR-C0019-M010
- Product description6BIO ≥99%(NMR)
- Packaging10mg
- Price$130
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0056-M001
- Product description6BIO ≥98%(NMR)
- Packaging1mg
- Price$30
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0056-M005
- Product description6BIO ≥98%(NMR)
- Packaging5mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0056-M005
- Product description6BIO ≥98%(NMR)
- Packaging5mg
- Price$65
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-MR-C0019-M050
- Product description6BIO ≥99%(NMR)
- Packaging50mg
- Price$480
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-MR-C0019-M050
- Product description6BIO ≥99%(NMR)
- Packaging50mg
- Price$490
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0056-M025
- Product description6BIO ≥98%(NMR)
- Packaging25mg
- Price$260
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number2268AH
- Product description(3Z)-6-Bromo-3-[(3E)-3-hydroxyimino-1H-indol-2-ylidene]-1H-indol-2-one
- Packaging10mg
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2268AH
- Product description(3Z)-6-Bromo-3-[(3E)-3-hydroxyimino-1H-indol-2-ylidene]-1H-indol-2-one
- Packaging50mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1538
- Product descriptionGSK-3InhibitorIX(BIO)
- Packaging50mg
- Price$399
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00FBFK | BIO 98% | 1mg | $10 | 2026-05-28 | Buy |
| aablocks | AA00FBFK | BIO 98 | 25mg | $212 | 2026-05-28 | Buy |
| aablocks | AA00FBFK | BIO 98 | 50mg | $367 | 2026-05-28 | Buy |
| aablocks | AA00FBFK | BIO 98 | 100mg | $534 | 2026-05-28 | Buy |
| ACHEMBLOCK | M22580 | GSK-3 Inhibitor IX 98% | 100MG | $165 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22580 | GSK-3 Inhibitor IX 98% | 1G | $815 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-MR-C0019-M010 | 6BIO ≥99%(NMR) | 10mg | $130 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0056-M001 | 6BIO ≥98%(NMR) | 1mg | $30 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0056-M005 | 6BIO ≥98%(NMR) | 5mg | $65 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-0056-M005 | 6BIO ≥98%(NMR) | 5mg | $65 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-MR-C0019-M050 | 6BIO ≥99%(NMR) | 50mg | $480 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-MR-C0019-M050 | 6BIO ≥99%(NMR) | 50mg | $490 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0056-M025 | 6BIO ≥98%(NMR) | 25mg | $260 | 2026-05-06 | Buy |
| AK Scientific | 2268AH | (3Z)-6-Bromo-3-[(3E)-3-hydroxyimino-1H-indol-2-ylidene]-1H-indol-2-one | 10mg | $218 | 2021-12-16 | Buy |
| AK Scientific | 2268AH | (3Z)-6-Bromo-3-[(3E)-3-hydroxyimino-1H-indol-2-ylidene]-1H-indol-2-one | 50mg | $640 | 2021-12-16 | Buy |
| ApexBio Technology | B1538 | GSK-3InhibitorIX(BIO) | 50mg | $399 | 2021-12-16 | Buy |
Properties
Melting point :300°C(lit.)
Boiling point :554.3±50.0 °C(Predicted)
Density :1.80±0.1 g/cm3(Predicted)
RTECS :NM3241900
storage temp. :2-8°C
solubility :DMSO: >5 mg/mL
form :solid
pka :9.56±0.20(Predicted)
color :dark red
Sensitive :Air & Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,14,18H,(H,19,21)/b15-13-
InChIKey :WFRDXNRAUPBBTO-SQFISAMPSA-N
SMILES :Brc1cc2c(cc1)\C(=C3\Nc4c(cccc4)C\3N=O)\C(=O)N2
Boiling point :554.3±50.0 °C(Predicted)
Density :1.80±0.1 g/cm3(Predicted)
RTECS :NM3241900
storage temp. :2-8°C
solubility :DMSO: >5 mg/mL
form :solid
pka :9.56±0.20(Predicted)
color :dark red
Sensitive :Air & Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,14,18H,(H,19,21)/b15-13-
InChIKey :WFRDXNRAUPBBTO-SQFISAMPSA-N
SMILES :Brc1cc2c(cc1)\C(=C3\Nc4c(cccc4)C\3N=O)\C(=O)N2
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β (IC50 = 5 nM). Its specificity has been tested against various cyclin-dependent kinases (CDKs) (IC50s = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively). BIO was also tested for its specificity towards many other commonly studied kinases (IC50 ≥10 μM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency in human and mouse embryonic stem cells (ESCs). BIO is reported to maintain self-renewal in human and mouse ESCs as well as induce the differentiation of neonatal cardiomyocytes.More related product prices
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