xav-939
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- $7 - $3173
- Product name: xav-939
- CAS: 284028-89-3
- MF: C14H11F3N2OS
- MW: 312.31
- EINECS:687-302-1
- MDL Number:MFCD00106866
- Synonyms:2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-3H-thiopyrano[4,3-d]pyrimidin-4(5H)-one;XAV-939;XAV 939;xav-939;3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one;XAV 939/NVP-XAV939;XAV 939, >=98%;SteMolecule;1,5,7,8-Tetrahydro-2-[4-(trifluoroMethyl)phenyl]-4H-thiopyrano[4,3-d]pyriMidin-4-one
141 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Acints
- Advanced Chemicals Intermediat
- AK Scientific
- Ambeed
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 200mg
- 10mM(1mLinDMSO)
- 10mM(in1mLDMSO)
- 500mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO
- 10
- 10mM*1mLinDMSO(Solution)
- 2x25mg
- EvaluationSample
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1G
- 5g
- Manufactureraablocks
- Product numberAA0039CE
- Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%
- Packaging1mg
- Price$18
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039CE
- Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%(HPLC)
- Packaging5mg
- Price$32
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039CE
- Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%
- Packaging10mg
- Price$42
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039CE
- Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%(HPLC)
- Packaging25mg
- Price$88
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039CE
- Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%
- Packaging50mg
- Price$125
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039CE
- Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%
- Packaging100mg
- Price$196
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039CE
- Product description3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%
- Packaging250mg
- Price$359
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product number10254
- Product descriptionXAV-939 98%
- Packaging1G
- Price$500
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10254
- Product descriptionXAV-939 98%
- Packaging100MG
- Price$100
- Updated2026-05-27
- Buy
- ManufacturerAcints
- Product numberATI-06G-001
- Product description2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable
- Packaging250mg
- Price$189
- Updated2026-05-20
- Buy
- ManufacturerAcints
- Product numberACI-02730
- Product description2-(4-Trifluoromethyl-phenyl)-3,5,7,8-tetrahydro-thiopyrano[4,3-d]pyrimidin-4-one 95%+
- Packaging1g
- Price$498.15
- Updated2026-05-20
- Buy
- ManufacturerAcints
- Product numberATI-06G-001
- Product description2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable
- Packaging1g
- Price$378
- Updated2026-05-20
- Buy
- ManufacturerAcints
- Product numberATI-06G-001
- Product description2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable
- Packaging5g
- Price$918
- Updated2026-05-20
- Buy
- ManufacturerAcints
- Product numberACI-02730
- Product description2-(4-Trifluoromethyl-phenyl)-3,5,7,8-tetrahydro-thiopyrano[4,3-d]pyrimidin-4-one 95%+
- Packaging5g
- Price$1510.65
- Updated2026-05-20
- Buy
- ManufacturerAdvanced Chemicals Intermediat
- Product numberATI-06G-001
- Product description2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable
- Packaging5g
- Price$918
- Updated2026-05-19
- Buy
- ManufacturerAdvanced Chemicals Intermediat
- Product numberACI-02730
- Product description2-(4-Trifluoromethyl-phenyl)-3,5,7,8-tetrahydro-thiopyrano[4,3-d]pyrimidin-4-one 95%+
- Packaging5g
- Price$1510.65
- Updated2026-05-19
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0039CE | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98% | 1mg | $18 | 2026-05-28 | Buy |
| aablocks | AA0039CE | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%(HPLC) | 5mg | $32 | 2026-05-28 | Buy |
| aablocks | AA0039CE | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98% | 10mg | $42 | 2026-05-28 | Buy |
| aablocks | AA0039CE | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98%(HPLC) | 25mg | $88 | 2026-05-28 | Buy |
| aablocks | AA0039CE | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98% | 50mg | $125 | 2026-05-28 | Buy |
| aablocks | AA0039CE | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98% | 100mg | $196 | 2026-05-28 | Buy |
| aablocks | AA0039CE | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one 98% | 250mg | $359 | 2026-05-28 | Buy |
| ACHEMBLOCK | 10254 | XAV-939 98% | 1G | $500 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10254 | XAV-939 98% | 100MG | $100 | 2026-05-27 | Buy |
| Acints | ATI-06G-001 | 2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable | 250mg | $189 | 2026-05-20 | Buy |
| Acints | ACI-02730 | 2-(4-Trifluoromethyl-phenyl)-3,5,7,8-tetrahydro-thiopyrano[4,3-d]pyrimidin-4-one 95%+ | 1g | $498.15 | 2026-05-20 | Buy |
| Acints | ATI-06G-001 | 2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable | 1g | $378 | 2026-05-20 | Buy |
| Acints | ATI-06G-001 | 2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable | 5g | $918 | 2026-05-20 | Buy |
| Acints | ACI-02730 | 2-(4-Trifluoromethyl-phenyl)-3,5,7,8-tetrahydro-thiopyrano[4,3-d]pyrimidin-4-one 95%+ | 5g | $1510.65 | 2026-05-20 | Buy |
| Advanced Chemicals Intermediat | ATI-06G-001 | 2-(4-Trifluoromethyl-phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol Notavailable | 5g | $918 | 2026-05-19 | Buy |
| Advanced Chemicals Intermediat | ACI-02730 | 2-(4-Trifluoromethyl-phenyl)-3,5,7,8-tetrahydro-thiopyrano[4,3-d]pyrimidin-4-one 95%+ | 5g | $1510.65 | 2026-05-19 | Buy |
Properties
Boiling point :429.3±55.0 °C(Predicted)
Density :1.5
Flash point :213.4℃
storage temp. :room temp
solubility :DMSO: soluble5mg/mL, clear
form :powder
pka :0.23±0.20(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChI :1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
InChIKey :KLGQSVMIPOVQAX-UHFFFAOYSA-N
SMILES :FC(F)(F)c1ccc(cc1)C2=NC3=C(CSCC3)C(=O)N2
Density :1.5
Flash point :213.4℃
storage temp. :room temp
solubility :DMSO: soluble5mg/mL, clear
form :powder
pka :0.23±0.20(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChI :1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
InChIKey :KLGQSVMIPOVQAX-UHFFFAOYSA-N
SMILES :FC(F)(F)c1ccc(cc1)C2=NC3=C(CSCC3)C(=O)N2
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
The Wnt signaling pathway is integral to normal biological processes and inappropriately active in many cancers. It is regulated through degradation of the downstream effector β-catenin via a complex consisting of the tumor suppressor APC, axin, and glycogen synthase kinase 3 (GSK3). Axin is the concentration-limiting factor for this degradation complex. Initially indentified as telomere-associated proteins, tankyrases promote axin ubiquitination, possibly through poly-ADP-ribosylation (PARsylation). XAV939 is a potent, small molecule inhibitor of tankyrase (TNKS) 1 and 2 with IC50 values of 11 and 4 nM, respectively. By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells. At concentrations as low as 0.33 μM, XAV939 inhibits colony formation of APC-deficient colorectal cancer cells.More related product prices
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