IWR-1-endo
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- $23 - $1802
- Product name: IWR-1-endo
- CAS: 1127442-82-3
- MF: C25H19N3O3
- MW: 409.44
- EINECS:
- MDL Number:MFCD18086875
- Synonyms:[(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide;Benzamide, 4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinyl-, rel-;endo-IWR 1;IWR-1-endo;rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-Methano-2H-isoindol-2-yl]-N-8-quinolinylbenzaMide;rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide IWR-1-endo;IWR-1-endo, >=98%;ENDO-IWR 1;IWR-1-ENDO;IWR1;IWR 1
92 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 500mg
- 1000mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- 10
- 50
- 10mM*1mLinDMSO
- 10 mg
- 10mM(in1mLDMSO)
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250MG
- 1G
- Manufactureraablocks
- Product numberAA0078ZV
- Product descriptionrel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide 98%
- Packaging1mg
- Price$23
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0078ZV
- Product descriptionrel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide 98%
- Packaging5mg
- Price$38
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0078ZV
- Product descriptionrel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide 98%
- Packaging10mg
- Price$68
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0078ZV
- Product descriptionrel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide 98
- Packaging50mg
- Price$265
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0078ZV
- Product descriptionrel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide 98
- Packaging25mg
- Price$155
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0078ZV
- Product descriptionrel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide 98
- Packaging100mg
- Price$371
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberX181661
- Product descriptionIWR-1-endo 98%
- Packaging250MG
- Price$345
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX181661
- Product descriptionIWR-1-endo 98%
- Packaging100MG
- Price$250
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberX181661
- Product descriptionIWR-1-endo 98%
- Packaging1G
- Price$720
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3581-M025
- Product descriptionIWR-1-endo ≥98%
- Packaging25mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3581-M005
- Product descriptionIWR-1-endo ≥98%
- Packaging5mg
- Price$90
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number1806AH
- Product descriptionIWR-1-endo
- Packaging5mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number1806AH
- Product descriptionIWR-1-endo
- Packaging10mg
- Price$162
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA205590
- Product descriptionrel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide 99+%
- Packaging10mg
- Price$122
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA205590
- Product descriptionrel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide 99+%
- Packaging50mg
- Price$311
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA205590
- Product descriptionrel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide 99+%
- Packaging5mg
- Price$72
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0078ZV | rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide 98% | 1mg | $23 | 2026-05-28 | Buy |
| aablocks | AA0078ZV | rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide 98% | 5mg | $38 | 2026-05-28 | Buy |
| aablocks | AA0078ZV | rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide 98% | 10mg | $68 | 2026-05-28 | Buy |
| aablocks | AA0078ZV | rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide 98 | 50mg | $265 | 2026-05-28 | Buy |
| aablocks | AA0078ZV | rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide 98 | 25mg | $155 | 2026-05-28 | Buy |
| aablocks | AA0078ZV | rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide 98 | 100mg | $371 | 2026-05-28 | Buy |
| ACHEMBLOCK | X181661 | IWR-1-endo 98% | 250MG | $345 | 2026-05-27 | Buy |
| ACHEMBLOCK | X181661 | IWR-1-endo 98% | 100MG | $250 | 2026-05-27 | Buy |
| ACHEMBLOCK | X181661 | IWR-1-endo 98% | 1G | $720 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-3581-M025 | IWR-1-endo ≥98% | 25mg | $360 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3581-M005 | IWR-1-endo ≥98% | 5mg | $90 | 2026-05-06 | Buy |
| AK Scientific | 1806AH | IWR-1-endo | 5mg | $118 | 2021-12-16 | Buy |
| AK Scientific | 1806AH | IWR-1-endo | 10mg | $162 | 2021-12-16 | Buy |
| Ambeed | A205590 | rel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide 99+% | 10mg | $122 | 2021-12-16 | Buy |
| Ambeed | A205590 | rel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide 99+% | 50mg | $311 | 2021-12-16 | Buy |
| Ambeed | A205590 | rel-4-((3aR,4S,7R,7aS)-1,3-Dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-(quinolin-8-yl)benzamide 99+% | 5mg | $72 | 2021-12-16 | Buy |
Properties
alpha :-3.0～+3.0°(20℃/D)(c=0.1,CH3CN)
Boiling point :643.9±55.0 °C(Predicted)
Density :1.425±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble5mg/mL, clear
form :Liquid
pka :11.88±0.43(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :ZGSXEXBYLJIOGF-ALFLXDJESA-N
SMILES :N4(C(=O)[C@@H]5[C@@H]([C@H]6C[C@@H]5C=C6)C4=O)c1ccc(cc1)C(=O)Nc2c3ncccc3ccc2
Boiling point :643.9±55.0 °C(Predicted)
Density :1.425±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble5mg/mL, clear
form :Liquid
pka :11.88±0.43(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :ZGSXEXBYLJIOGF-ALFLXDJESA-N
SMILES :N4(C(=O)[C@@H]5[C@@H]([C@H]6C[C@@H]5C=C6)C4=O)c1ccc(cc1)C(=O)Nc2c3ncccc3ccc2
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
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| Precautionary statements: |
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Description
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. It inhibits, at 10 μM, Wnt-induced accumulation of β-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, Ck1, and GSK3β. IWR-1-endo stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK3β. The IWR compound does not change the de novo synthesis of Axin2, alter the affinity of Axin2 for β-catenin, or inhibit the proteasome. It has a half-life of 60 minutes in murine whole blood and 20 minutes in intact murine hepatocytes. In in vivo tests, IWR-1-endo inhibits zebrafish tail fin regeneration with a minimum inhibitory concentration of 0.5 μM. The IWR-1-exo diastereomer exhibits much less activity against the Wnt/β-catenin pathway and has been used as a control.More related product prices
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Hunan Jibang Biological Technology Co., LTD
ShenZhen Trendseen Biological Technology Co.,Ltd.
