Bindarit
|
- $25 - $1842
- Product name: Bindarit
- CAS: 130641-38-2
- MF: C19H20N2O3
- MW: 324.37
- EINECS:
- MDL Number:MFCD00866723
- Synonyms:Bindarit;Propanoic acid, 2-Methyl-2-[[1-(phenylMethyl)-1H-indazol-3-yl]Methoxy]-;2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropionic acid;AF 2838;2-((1-Benzyl-1H-indazol-3-yl)Methoxy)-2-Methylpropanoic acid;AF2838;AF-2838;AF 2838;CS-1989;2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid
69 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Usbiological
Package
- 10mM(in1mLDMSO)
- 10mM*1mLinDMSO(Solution)
- 1mg
- 5mg
- 10mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 25mg
- 10mM*1mLinDMSO
- EvaluationSample
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1G
- 5g
- Manufactureraablocks
- Product numberAA000UNS
- Product description2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid ≥98%
- Packaging1mg
- Price$28
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000UNS
- Product description2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid ≥98%
- Packaging10mg
- Price$63
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000UNS
- Product description2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid ≥98%
- Packaging5mg
- Price$32
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000UNS
- Product description2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid 99%
- Packaging25mg
- Price$135
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000UNS
- Product description2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid 99%
- Packaging100mg
- Price$358
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000UNS
- Product description2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid
- Packaging200mg
- Price$651
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product number10234
- Product descriptionBindarit 98%
- Packaging1G
- Price$1150
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product number10234
- Product descriptionBindarit 98%
- Packaging1G
- Price$1150
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10234
- Product descriptionBindarit 98%
- Packaging25MG
- Price$95
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product number10234
- Product descriptionBindarit 98%
- Packaging100MG
- Price$295
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product number10234
- Product descriptionBindarit 98%
- Packaging100MG
- Price$295
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10234
- Product descriptionBindarit 98%
- Packaging5MG
- Price$35
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product number10234
- Product descriptionBindarit 98%
- Packaging5MG
- Price$35
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10234
- Product descriptionBindarit 98%
- Packaging25MG
- Price$95
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX6136
- Product descriptionBindarit
- Packaging100mg
- Price$455
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0010496
- Product description2-(1-BENZYL-1H-INDAZOL-3-YL)METHOXY-2-METHYLPROPANOIC ACID 95.00%
- Packaging5MG
- Price$330
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000UNS | 2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid ≥98% | 1mg | $28 | 2026-05-25 | Buy |
| aablocks | AA000UNS | 2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid ≥98% | 10mg | $63 | 2026-05-25 | Buy |
| aablocks | AA000UNS | 2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid ≥98% | 5mg | $32 | 2026-05-25 | Buy |
| aablocks | AA000UNS | 2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid 99% | 25mg | $135 | 2026-05-25 | Buy |
| aablocks | AA000UNS | 2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid 99% | 100mg | $358 | 2026-05-25 | Buy |
| aablocks | AA000UNS | 2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid | 200mg | $651 | 2026-05-25 | Buy |
| ACHEMBLOCK | 10234 | Bindarit 98% | 1G | $1150 | 2026-05-25 | Buy |
| ACHEMBLOCK | 10234 | Bindarit 98% | 1G | $1150 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10234 | Bindarit 98% | 25MG | $95 | 2026-05-25 | Buy |
| ACHEMBLOCK | 10234 | Bindarit 98% | 100MG | $295 | 2026-05-25 | Buy |
| ACHEMBLOCK | 10234 | Bindarit 98% | 100MG | $295 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10234 | Bindarit 98% | 5MG | $35 | 2026-05-25 | Buy |
| ACHEMBLOCK | 10234 | Bindarit 98% | 5MG | $35 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10234 | Bindarit 98% | 25MG | $95 | 2026-05-27 | Buy |
| AK Scientific | X6136 | Bindarit | 100mg | $455 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010496 | 2-(1-BENZYL-1H-INDAZOL-3-YL)METHOXY-2-METHYLPROPANOIC ACID 95.00% | 5MG | $330 | 2021-12-16 | Buy |
Properties
Boiling point :542.9±40.0 °C(Predicted)
Density :1.18±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. :2-8°C
solubility :DMSO:47.0(Max Conc. mg/mL);144.89(Max Conc. mM)
form :A crystalline solid
pka :3.59±0.10(Predicted)
color :White to off-white
InChI :InChI=1S/C19H20N2O3/c1-19(2,18(22)23)24-13-16-15-10-6-7-11-17(15)21(20-16)12-14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3,(H,22,23)
InChIKey :MTHORRSSURHQPZ-UHFFFAOYSA-N
SMILES :C(O)(=O)C(C)(OCC1C2=C(N(CC3=CC=CC=C3)N=1)C=CC=C2)C
Density :1.18±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. :2-8°C
solubility :DMSO:47.0(Max Conc. mg/mL);144.89(Max Conc. mM)
form :A crystalline solid
pka :3.59±0.10(Predicted)
color :White to off-white
InChI :InChI=1S/C19H20N2O3/c1-19(2,18(22)23)24-13-16-15-10-6-7-11-17(15)21(20-16)12-14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3,(H,22,23)
InChIKey :MTHORRSSURHQPZ-UHFFFAOYSA-N
SMILES :C(O)(=O)C(C)(OCC1C2=C(N(CC3=CC=CC=C3)N=1)C=CC=C2)C
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Monocyte chemoattractant protein-1 (MCP-1/CCL2) and other members of the MCP cluster (MCP-2/CCL8 and MCP-3/CCL7) are potent chemotactic cytokines that collaboratively promote inflammation through monocyte-macrophage recruitment. Bindarit is an indazolic derivative that inhibits the expression of CCL2, CCL7, and CCL8, as well as IL-12. It can inhibit LPS- or C. albicans-induced production of CCL2 in human monocytes with IC50 values of 172 and 403 μM, respectively. Bindarit has been shown to downregulate the NF-κB pathway, preventing p65 and p65/p50-mediated CCL2 promoter activation. Through potent suppression of CCL2 transcription, bindarit has been reported to reduce symptoms in several animal models of human inflammatory diseases, including lupus nephritis, arthritis, cancer, and encephalomyelitis.Related product price
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