(+)-Camptothecin
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- $9 - $1900.44
- Product name: (+)-Camptothecin
- CAS: 7689-03-4
- MF: C20H16N2O4
- MW: 348.35
- EINECS:444-280-6
- MDL Number:MFCD00081076
- Synonyms:CaMpetothecin;(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;CaMptothecin(NATURAL);4-ETHYL-4-HYDROXY-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)DIONE;5,6-DIHYDROXY-4-OXO-2-PHENYL-4H-1-BENZOPYRAN-7-YL BETA-D-GLUCOPYRANOSIDURONIC ACID;(s)-droxy ;1h-pyrano(3’,4’:6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione,4-ethyl-4-hy ;(+)-Camptothecin 4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
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Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
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- 1g
- 5g
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- 50 mg
- Manufactureraablocks
- Product numberAA003B9O
- Product description(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98%
- Packaging1mg
- Price$9
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003B9O
- Product description(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥97%
- Packaging100mg
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003B9O
- Product description(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98%
- Packaging1g
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003B9O
- Product description(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥97%
- Packaging250mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003B9O
- Product description(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98%
- Packaging5g
- Price$42
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003B9O
- Product description(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98%
- Packaging25g
- Price$162
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberF-4794
- Product descriptionCamptothecin 98%
- Packaging25G
- Price$230
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberF-4794
- Product descriptionCamptothecin 98%
- Packaging25G
- Price$230
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0463-M050
- Product description(S)-(+)-Camptothecin >98%(HPLC)
- Packaging50mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0463-M050
- Product description(S)-(+)-Camptothecin >98%(HPLC)
- Packaging50mg
- Price$25
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0463-M250
- Product description(S)-(+)-Camptothecin >98%(HPLC)
- Packaging250mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CN2-0463-M250
- Product description(S)-(+)-Camptothecin >98%(HPLC)
- Packaging250mg
- Price$90
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product numberK332
- Product description(S)-(+)-Camptothecin
- Packaging25g
- Price$327
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ10012
- Product description(S)-(+)-Camptothecin
- Packaging1g
- Price$155
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA159794
- Product description(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
- Packaging10g
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA159794
- Product description(S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
- Packaging25g
- Price$266
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA003B9O | (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98% | 1mg | $9 | 2026-05-28 | Buy |
| aablocks | AA003B9O | (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥97% | 100mg | $10 | 2026-05-28 | Buy |
| aablocks | AA003B9O | (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98% | 1g | $12 | 2026-05-28 | Buy |
| aablocks | AA003B9O | (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ≥97% | 250mg | $12 | 2026-05-28 | Buy |
| aablocks | AA003B9O | (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98% | 5g | $42 | 2026-05-28 | Buy |
| aablocks | AA003B9O | (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98% | 25g | $162 | 2026-05-28 | Buy |
| ACHEMBLOCK | F-4794 | Camptothecin 98% | 25G | $230 | 2026-05-25 | Buy |
| ACHEMBLOCK | F-4794 | Camptothecin 98% | 25G | $230 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CN2-0463-M050 | (S)-(+)-Camptothecin >98%(HPLC) | 50mg | $25 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CN2-0463-M050 | (S)-(+)-Camptothecin >98%(HPLC) | 50mg | $25 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CN2-0463-M250 | (S)-(+)-Camptothecin >98%(HPLC) | 250mg | $90 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CN2-0463-M250 | (S)-(+)-Camptothecin >98%(HPLC) | 250mg | $90 | 2026-05-06 | Buy |
| AK Scientific | K332 | (S)-(+)-Camptothecin | 25g | $327 | 2021-12-16 | Buy |
| AK Scientific | J10012 | (S)-(+)-Camptothecin | 1g | $155 | 2021-12-16 | Buy |
| Ambeed | A159794 | (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% | 10g | $120 | 2021-12-16 | Buy |
| Ambeed | A159794 | (S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% | 25g | $266 | 2021-12-16 | Buy |
Properties
Melting point :260 °C (dec.)(lit.)
alpha :D25 +31.3° (in chloroform-methanol, 8:2)
Boiling point :482.73°C (rough estimate)
Density :1.3112 (rough estimate)
refractive index :1.5700 (estimate)
storage temp. :2-8°C
solubility :chloroform/methanol (4:1): 4 mg/mL
form :solid
pka :pKa 10.83 (Uncertain)
color :yellow
optical activity :Consistent with structure
Water Solubility :insoluble
Merck :14,1735
BRN :631069
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
InChIKey :VSJKWCGYPAHWDS-FQEVSTJZSA-N
SMILES :CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5ccccc5nc34)C2=O
LogP :1.740
CAS DataBase Reference :7689-03-4(CAS DataBase Reference)
alpha :D25 +31.3° (in chloroform-methanol, 8:2)
Boiling point :482.73°C (rough estimate)
Density :1.3112 (rough estimate)
refractive index :1.5700 (estimate)
storage temp. :2-8°C
solubility :chloroform/methanol (4:1): 4 mg/mL
form :solid
pka :pKa 10.83 (Uncertain)
color :yellow
optical activity :Consistent with structure
Water Solubility :insoluble
Merck :14,1735
BRN :631069
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
InChIKey :VSJKWCGYPAHWDS-FQEVSTJZSA-N
SMILES :CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5ccccc5nc34)C2=O
LogP :1.740
CAS DataBase Reference :7689-03-4(CAS DataBase Reference)
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||
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Description
DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs at the cleavage site, thus inhibiting religa Camptothecin is a cytotoxic, quinoline alkaloid, discovered as the active principle of extracts from the Chinese tree C. acuminate, that inhibits the DNA enzyme topoisomerase I (Top1). It binds the Top1-DNA cleavage complex, inducing DNA-strand breaks. Camptothecin has strong anti-tumor activity against a wide range of experimental tumors and inhibits both DNA and RNA synthesis in mammalian cells. It displays cytotoxity in HT-29 cells with an IC50 value of 10 nM and induces DNA damage at concentrations as low as 51 nM in whole cells and 12 nM in isolated nuclei in in vitro assays.More related product prices
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