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ChemicalBook >> CAS DataBase List >> Ceritinib (LDK378)

Ceritinib (LDK378)

Ceritinib (LDK378) price.
  • $8 - $3600
  • Product name: Ceritinib (LDK378)
  • CAS: 1032900-25-6
  • MF: C28H36ClN5O3S
  • MW: 558.14
  • EINECS:811-457-8
  • MDL Number:MFCD26142648
  • Synonyms:Eritinib;5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)p;Ceritinib (LDK378);LDK 378 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine;Eritinib (LDK378);Ceritinib, >=98%;LDK37;CS-819
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  • 10mM(in1mLDMSO)
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  • Manufactureraablocks
  • Product numberAA003A96
  • Product description5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine 98%
  • Packaging1mg
  • Price$8
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA003A96
  • Product description5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine 98%
  • Packaging5mg
  • Price$10
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA003A96
  • Product description5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine ≥99%
  • Packaging25mg
  • Price$13
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA003A96
  • Product description5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine ≥99%
  • Packaging100mg
  • Price$15
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA003A96
  • Product description5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine ≥99%
  • Packaging250mg
  • Price$21
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA003A96
  • Product description5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine 98%
  • Packaging1g
  • Price$36
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA003A96
  • Product description5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine 98%
  • Packaging25g
  • Price$718
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product number10239
  • Product descriptionLDK378 98%
  • Packaging1G
  • Price$36
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product number10239
  • Product descriptionLDK378 98%
  • Packaging1G
  • Price$36
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product number10239
  • Product descriptionLDK378 98%
  • Packaging100MG
  • Price$12
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product number10239
  • Product descriptionLDK378 98%
  • Packaging100MG
  • Price$12
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product number10239
  • Product descriptionLDK378 98%
  • Packaging5G
  • Price$136
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product number10239
  • Product descriptionLDK378 98%
  • Packaging5G
  • Price$136
  • Updated2026-05-27
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1199-M001
  • Product descriptionLDK378 ≥95%
  • Packaging1mg
  • Price$65
  • Updated2026-05-06
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  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1199-M005
  • Product descriptionLDK378 ≥95%
  • Packaging5mg
  • Price$97
  • Updated2026-05-06
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  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1199-M010
  • Product descriptionLDK378 ≥95%
  • Packaging10mg
  • Price$130
  • Updated2026-05-06
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Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA003A96 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine 98% 1mg $8 2026-05-28 Buy
aablocks AA003A96 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine 98% 5mg $10 2026-05-28 Buy
aablocks AA003A96 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine ≥99% 25mg $13 2026-05-28 Buy
aablocks AA003A96 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine ≥99% 100mg $15 2026-05-28 Buy
aablocks AA003A96 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine ≥99% 250mg $21 2026-05-28 Buy
aablocks AA003A96 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine 98% 1g $36 2026-05-28 Buy
aablocks AA003A96 5-Chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine 98% 25g $718 2026-05-28 Buy
ACHEMBLOCK 10239 LDK378 98% 1G $36 2026-05-25 Buy
ACHEMBLOCK 10239 LDK378 98% 1G $36 2026-05-27 Buy
ACHEMBLOCK 10239 LDK378 98% 100MG $12 2026-05-25 Buy
ACHEMBLOCK 10239 LDK378 98% 100MG $12 2026-05-27 Buy
ACHEMBLOCK 10239 LDK378 98% 5G $136 2026-05-25 Buy
ACHEMBLOCK 10239 LDK378 98% 5G $136 2026-05-27 Buy
Adipogen Life Sciences SYN-1199-M001 LDK378 ≥95% 1mg $65 2026-05-06 Buy
Adipogen Life Sciences SYN-1199-M005 LDK378 ≥95% 5mg $97 2026-05-06 Buy
Adipogen Life Sciences SYN-1199-M010 LDK378 ≥95% 10mg $130 2026-05-06 Buy

Properties

Melting point :173-175°C
Boiling point :720.7±70.0 °C(Predicted)
Density :1.251±0.06 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :Chloroform (Slightly), Methanol (Slightly)
pka :10.16±0.10(Predicted)
form :Off-white solid.
color :White to Off-White
InChIKey :VERWOWGGCGHDQE-UHFFFAOYSA-N
SMILES :C1(NC2=CC(C)=C(C3CCNCC3)C=C2OC(C)C)=NC=C(Cl)C(NC2=CC=CC=C2S(C(C)C)(=O)=O)=N1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Ceritinib (previously LDK378l, brand name Zykadia; Novartis Pharmaceuticals) is an oral small molecule tyrosine kinase inhibitor of ALK [87]. Preclinical studies suggested that it would inhibit ROS1 as well [88, 89].

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