Dapagliflozin
|
- $5 - $2631.5
- Product name: Dapagliflozin
- CAS: 461432-26-8
- MF: C21H25ClO6
- MW: 408.88
- EINECS:639-683-0
- MDL Number:MFCD13182359
- Synonyms:Dapagliflozin(BMS-512148);1-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-1-deoxy-beta-D-glucopyranose (1S)-1,5-Anhydro-1-C-[4-chloro-3-(4-ethoxybenzyl)phenyl]-D-glucitol (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxyMethyl)tetrahydro-2H-pyran-3,4,5-triol;(2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxyMethyltetrahydro-2H-pyran-3,4,5-triol;1-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-1-deoxy-beta-D-glucopyranose;BMS5121458;Dag coluMn net;Dapagliflozin Isomer Impurity;Dapagliflozin, >=98%
116 prices
Selected condition：
Brand
- aablocks
- AccelPharmtech
- ACHEMBLOCK
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- TCI Chemical
- Thermo Scientific Chemicals
- TRC
- Usbiological
Package
- 20mg
- 2g
- 50g
- 500mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM(in1mLDMSO)
- 1mg
- 1.00g
- 5.00g
- 10.00g
- 1 g
- 10mM*1mLinDMSO
- 5 g
- 10mM*1mLinDMSO(Solution)
- 1unit
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 5g
- EvaluationSample
- 25g
- 10mM(in 1mL DMSO)
- 10g
- 100g
- Manufactureraablocks
- Product numberAA0039DR
- Product description(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol ≥99%
- Packaging10mg
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039DR
- Product description(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol ≥99%
- Packaging50mg
- Price$11
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039DR
- Product description(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol ≥99%
- Packaging250mg
- Price$20
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039DR
- Product description(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol ≥99%
- Packaging1g
- Price$40
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039DR
- Product description(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol ≥99%
- Packaging5g
- Price$140
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039DR
- Product description(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol ≥99%
- Packaging25g
- Price$430
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039DR
- Product description(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol 98%
- Packaging100g
- Price$1342
- Updated2026-05-28
- Buy
- ManufacturerAccelPharmtech
- Product numberTR0047910g
- Product descriptionDapagliflozin 99%
- Packaging
- Price$267
- Updated2026-05-21
- Buy
- ManufacturerAccelPharmtech
- Product numberTR00479
- Product descriptionDapagliflozin 99%
- Packaging10g
- Price$267
- Updated2026-05-21
- Buy
- ManufacturerACHEMBLOCK
- Product numberG-7893
- Product descriptionDapagliflozin 98%
- Packaging5G
- Price$140
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberG-7893
- Product descriptionDapagliflozin 98%
- Packaging1G
- Price$45
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberG-7893
- Product descriptionDapagliflozin 98%
- Packaging25G
- Price$430
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberG-7893
- Product descriptionDapagliflozin 98%
- Packaging100G
- Price$1150
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberJ95139
- Product descriptionDapagliflozin
- Packaging10g
- Price$380
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ95139
- Product descriptionDapagliflozin
- Packaging1g
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA120381
- Product description(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+%
- Packaging1g
- Price$81
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0039DR | (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol ≥99% | 10mg | $10 | 2026-05-28 | Buy |
| aablocks | AA0039DR | (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol ≥99% | 50mg | $11 | 2026-05-28 | Buy |
| aablocks | AA0039DR | (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol ≥99% | 250mg | $20 | 2026-05-28 | Buy |
| aablocks | AA0039DR | (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol ≥99% | 1g | $40 | 2026-05-28 | Buy |
| aablocks | AA0039DR | (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol ≥99% | 5g | $140 | 2026-05-28 | Buy |
| aablocks | AA0039DR | (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol ≥99% | 25g | $430 | 2026-05-28 | Buy |
| aablocks | AA0039DR | (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol 98% | 100g | $1342 | 2026-05-28 | Buy |
| AccelPharmtech | TR0047910g | Dapagliflozin 99% | $267 | 2026-05-21 | Buy | |
| AccelPharmtech | TR00479 | Dapagliflozin 99% | 10g | $267 | 2026-05-21 | Buy |
| ACHEMBLOCK | G-7893 | Dapagliflozin 98% | 5G | $140 | 2026-05-27 | Buy |
| ACHEMBLOCK | G-7893 | Dapagliflozin 98% | 1G | $45 | 2026-05-27 | Buy |
| ACHEMBLOCK | G-7893 | Dapagliflozin 98% | 25G | $430 | 2026-05-27 | Buy |
| ACHEMBLOCK | G-7893 | Dapagliflozin 98% | 100G | $1150 | 2026-05-27 | Buy |
| AK Scientific | J95139 | Dapagliflozin | 10g | $380 | 2021-12-16 | Buy |
| AK Scientific | J95139 | Dapagliflozin | 1g | $70 | 2021-12-16 | Buy |
| Ambeed | A120381 | (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 97+% | 1g | $81 | 2021-12-16 | Buy |
Properties
Melting point :55-58°C
Boiling point :609.0±55.0 °C(Predicted)
Density :1.349
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.23±0.70(Predicted)
form :Solid
color :White to Pale Yellow
optical activity :[α]/D (+7.0° to +13.0°, c = 0.2 in methanol)
Stability :Hygroscopic
InChI :1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
InChIKey :JVHXJTBJCFBINQ-JNTNYNDRNA-N
SMILES :O[C@@H]1[C@H]([C@H](O)[C@@H](CO)O[C@H]1C1C=CC(Cl)=C(CC2C=CC(OCC)=CC=2)C=1)O |&1:1,2,3,5,9,r|
Boiling point :609.0±55.0 °C(Predicted)
Density :1.349
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :13.23±0.70(Predicted)
form :Solid
color :White to Pale Yellow
optical activity :[α]/D (+7.0° to +13.0°, c = 0.2 in methanol)
Stability :Hygroscopic
InChI :1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1
InChIKey :JVHXJTBJCFBINQ-JNTNYNDRNA-N
SMILES :O[C@@H]1[C@H]([C@H](O)[C@@H](CO)O[C@H]1C1C=CC(Cl)=C(CC2C=CC(OCC)=CC=2)C=1)O |&1:1,2,3,5,9,r|
Safety Information
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| Signal word: | Danger | ||||||||||||||||||||||||||||
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Description
Inhibiting renal glucose reabsorbtion through the sodium-glucose cotransporter (SGLT) offers an insulin-independent alternative to controlling blood glucose concentrations in patients with type 2 diabetes. While the majority of glucose is reabsorbed from glomerular filtrate by SGLT2, which is predominantly expressed in the kidney S1 segment of the proximal tubule, SGLT1 reabsorbs glucose in the distal S3 segment of the renal proximal tubule as well as from the small intestine. Dapagliflozin is a first generation, selective SGLT inhibitor that blocks glucose transport with about 100-fold selectivity for SGLT2 (Ki = 6 nM; EC50 = 1.1 nM) over SGLT1 (Ki = 390 nM). After single oral doses ranging from 0.1 to 1.0 mg/kg, dapagliflozin increases urinary glucose excretion in both normal and diabetic rats, improves glucose tolerance in normal rats, and reduces hyperglycemia in Zucker diabetic fatty rats. Within two weeks of treating diabetic rats with 0.1 to 1.0 mg/kg dapagliflozin, fasting and fed glucose levels have been shown to be significantly lowered as a result of increased glucose utilization accompanied by reduced glucose production.Related product price
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Suppliers and manufacturers
Changzhou Rokechem Technology Co., Ltd.
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RongNa Biotechnology Co.,Ltd
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shandong perfect biotechnology co.ltd
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![(2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol](/ProductImageEN/2023-07/small/bbe4e95a-455f-4b91-9103-e8369bb36ee3.png){kind=small}
Hebei Xinsheng New Material Technology Co., LTD.
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd.
Senova Technology Co. Ltd.
Hubei Ipure Biology Co., Ltd
Protheragen-ING
Dapagliflozin
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