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ChemicalBook >> CAS DataBase List >> Dimethyl fumarate

Dimethyl fumarate

Dimethyl fumarate price.
  • $5 - $1760
  • Product name: Dimethyl fumarate
  • CAS: 624-49-7
  • MF: C6H8O4
  • MW: 144.13
  • EINECS:210-849-0
  • MDL Number:MFCD00064438
  • Synonyms:But-2-enedioicaciddimethylester;Fumaric acid, bis-methyl ester;Dimethyl furmarate;DiMethyl fuMarate, 99% 100GR;DiMethyl fuMarate, 99% 25GR;trans-butenedioicacid,dimethylester ;trans-butenedioicaciddimethylester ;Dimethyl fumarate,99%
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  • aablocks
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  • Manufactureraablocks
  • Product numberAA003PJA
  • Product description(E)-Dimethyl fumarate 99%
  • Packaging100g
  • Price$9
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA003PJA
  • Product description(E)-Dimethyl fumarate 99%
  • Packaging250g
  • Price$17
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA003PJA
  • Product description(E)-Dimethyl fumarate 99%
  • Packaging500g
  • Price$22
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA003PJA
  • Product description(E)-Dimethyl fumarate 99%
  • Packaging1000g
  • Price$36
  • Updated2026-05-28
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  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3701-G025
  • Product descriptionDimethyl fumarate ≥95%
  • Packaging25g
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3701-G025
  • Product descriptionDimethyl fumarate ≥95%
  • Packaging25g
  • Price$30
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3701-G005
  • Product descriptionDimethyl fumarate ≥95%
  • Packaging5g
  • Price$22
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3701-G001
  • Product descriptionDimethyl fumarate ≥95%
  • Packaging1g
  • Price$15
  • Updated2026-05-06
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  • ManufacturerAK Scientific
  • Product numberJ61685
  • Product descriptionDimethyl fumarate 98%
  • Packaging100g
  • Price$53
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberF927
  • Product descriptionDimethyl fumarate >99%(GC)
  • Packaging100g
  • Price$70
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ61685
  • Product descriptionDimethyl fumarate 98%
  • Packaging500g
  • Price$150
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberF927
  • Product descriptionDimethyl fumarate
  • Packaging25g
  • Price$21.3
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberF927
  • Product descriptionDimethyl fumarate >99%(GC)
  • Packaging25g
  • Price$29
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ61685
  • Product descriptionDimethyl fumarate 98%
  • Packaging25g
  • Price$20
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberF927
  • Product descriptionDimethyl fumarate >99%(GC)
  • Packaging5g
  • Price$18
  • Updated2026-06-04
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ61685
  • Product descriptionDimethyl fumarate 98%
  • Packaging5g
  • Price$13
  • Updated2026-06-04
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA003PJA (E)-Dimethyl fumarate 99% 100g $9 2026-05-28 Buy
aablocks AA003PJA (E)-Dimethyl fumarate 99% 250g $17 2026-05-28 Buy
aablocks AA003PJA (E)-Dimethyl fumarate 99% 500g $22 2026-05-28 Buy
aablocks AA003PJA (E)-Dimethyl fumarate 99% 1000g $36 2026-05-28 Buy
Adipogen Life Sciences AG-CR1-3701-G025 Dimethyl fumarate ≥95% 25g $30 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-3701-G025 Dimethyl fumarate ≥95% 25g $30 2026-05-06 Buy
Adipogen Life Sciences AG-CR1-3701-G005 Dimethyl fumarate ≥95% 5g $22 2026-05-06 Buy
Adipogen Life Sciences AG-CR1-3701-G001 Dimethyl fumarate ≥95% 1g $15 2026-05-06 Buy
AK Scientific J61685 Dimethyl fumarate 98% 100g $53 2026-06-04 Buy
AK Scientific F927 Dimethyl fumarate >99%(GC) 100g $70 2026-06-04 Buy
AK Scientific J61685 Dimethyl fumarate 98% 500g $150 2026-06-04 Buy
AK Scientific F927 Dimethyl fumarate 25g $21.3 2021-12-16 Buy
AK Scientific F927 Dimethyl fumarate >99%(GC) 25g $29 2026-06-04 Buy
AK Scientific J61685 Dimethyl fumarate 98% 25g $20 2026-06-04 Buy
AK Scientific F927 Dimethyl fumarate >99%(GC) 5g $18 2026-06-04 Buy
AK Scientific J61685 Dimethyl fumarate 98% 5g $13 2026-06-04 Buy

Properties

Melting point :102-106 °C (lit.)
Boiling point :192-193 °C (lit.)
Density :1,37 g/cm3
vapor pressure :5 hPa (25 °C)
refractive index :1.4062 (estimate)
Flash point :192-193°C
storage temp. :Store below +30°C.
solubility :1.6g/l
form :Liquid
color :Clear colorless to faintly yellow
PH :4.0-6.0 (10g/l, H2O, 20℃)suspension
Water Solubility :Soluble in water (1.6 mg/ml at 20°C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25°C), DMSO (29 mg/ml at 25°C), and DMF (~12 mg/ml).
Merck :14,4287
BRN :774590
Henry's Law Constant :1.4×101 mol/(m3Pa) at 25℃, HSDB (2015)
Stability :Stable. Incompatible with acids, bases, oxidizing agents, reducing agents.
InChI :1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+
InChIKey :LDCRTTXIJACKKU-ONEGZZNKSA-N
SMILES :[H]\C(=C(\[H])C(=O)OC)C(=O)OC
CAS DataBase Reference :624-49-7(CAS DataBase Reference)
NIST Chemistry Reference :2-Butenedioic acid (E)-, dimethyl ester(624-49-7)
EPA Substance Registry System :2-Butenedioic acid (2E)-, 1,4-dimethyl ester (624-49-7)

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)Environment (GHS09)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Dimethyl fumarate is a lipophilic electrophile that has profound effects on oxidative and immunological pathways. It rapidly interacts in a Michael addition reaction with glutathione or is metabolized to monomethyl fumarate. Dimethyl fumarate at low micromolar levels activates the nuclear factor erythroid 2-related factor 2 (Nrf2), resulting in an antioxidant response featuring heme oxygenase-1 expression and increased glutathione levels. It also suppresses the expression of pro-inflammatory cytokines and inhibits angiogenesis. Through these actions dimethyl fumarate alters the course of psoriasis and may reduce inflammation related to multiple sclerosis.

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