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ChemicalBook >> CAS DataBase List >> (+)-JQ-1

(+)-JQ-1

$9 - $5000
Product name: (+)-JQ-1
CAS: 1268524-70-4
MF: C23H25ClN4O2S
MW: 456.99
EINECS:
MDL Number:MFCD22683748
Synonyms:(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thienol[3,2-f][1,2,4]troazolo[4,3-a][1,4]diazepin-6-yl)acetate[(+)-6];(+)-JQ1,(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;(+)-JQ1,(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate CAS：;BroModoMain Inhibitor, (+)-JQ1;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-triMethyl-, 1,1-diMethylethyl ester, (6S)-;(S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate (+)-JQ-1;(6s)-6-(2-Tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-F][1,2,4]triazolo[4,3-A][1,4]diazepin-10-ium

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aablocks
ACHEMBLOCK
Adipogen Life Sciences
AK Scientific
Ambeed
ApexBio Technology
Arctom
AvaChem
Axon Medchem
Biorbyt Ltd
Biosynth
BroadPharm
Cayman Chemical
ChemScene
Crysdot
DC Chemicals
Matrix Scientific
Medical Isotopes, Inc.
Sigma-Aldrich
Synthonix
Tocris
TRC
Usbiological

Package

2mg
10mM*1mLinDMSO
1mg
5mg
10mg
20mg
25mg
50mg
100mg
200mg
250mg
500mg
1000mg
1g
10
5g
10mM*1mLinDMSO(Solution)
EvaluationSample
10g
10mM*1mLinDMSO(Solid+Solvent)
10mM(in1mLDMSO)

Manufactureraablocks
Product numberAA000TA7
Product description(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%
Packaging1mg
Price$9
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000TA7
Product description(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%
Packaging10mg
Price$10
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000TA7
Product description(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate ≥98%(HPLC)
Packaging5mg
Price$10
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000TA7
Product description(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%
Packaging25mg
Price$17
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000TA7
Product description(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%
Packaging50mg
Price$20
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000TA7
Product description(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate >97%
Packaging100mg
Price$25
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000TA7
Product description(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate >97%
Packaging250mg
Price$45
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000TA7
Product description(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%
Packaging500mg
Price$75
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000TA7
Product description(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%
Packaging1g
Price$95
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000TA7
Product description(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%
Packaging5g
Price$266
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000TA7
Product description(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%
Packaging10g
Price$464
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberL14965
Product descriptionJQ 1 98%
Packaging5G
Price$845
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberL14965
Product descriptionJQ 1 98%
Packaging5G
Price$845
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberL14965
Product descriptionJQ 1 98%
Packaging1G
Price$190
Updated2026-05-25
Buy

ManufacturerACHEMBLOCK
Product numberL14965
Product descriptionJQ 1 98%
Packaging1G
Price$190
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberL14965
Product descriptionJQ 1 98%
Packaging100MG
Price$40
Updated2026-05-25
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA000TA7	(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%	1mg	$9	2026-05-25	Buy
aablocks	AA000TA7	(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%	10mg	$10	2026-05-25	Buy
aablocks	AA000TA7	(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate ≥98%(HPLC)	5mg	$10	2026-05-25	Buy
aablocks	AA000TA7	(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%	25mg	$17	2026-05-25	Buy
aablocks	AA000TA7	(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%	50mg	$20	2026-05-25	Buy
aablocks	AA000TA7	(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate >97%	100mg	$25	2026-05-25	Buy
aablocks	AA000TA7	(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate >97%	250mg	$45	2026-05-25	Buy
aablocks	AA000TA7	(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%	500mg	$75	2026-05-25	Buy
aablocks	AA000TA7	(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%	1g	$95	2026-05-25	Buy
aablocks	AA000TA7	(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%	5g	$266	2026-05-25	Buy
aablocks	AA000TA7	(S)-(+)-Tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 98%	10g	$464	2026-05-25	Buy
ACHEMBLOCK	L14965	JQ 1 98%	5G	$845	2026-05-25	Buy
ACHEMBLOCK	L14965	JQ 1 98%	5G	$845	2026-05-27	Buy
ACHEMBLOCK	L14965	JQ 1 98%	1G	$190	2026-05-25	Buy
ACHEMBLOCK	L14965	JQ 1 98%	1G	$190	2026-05-27	Buy
ACHEMBLOCK	L14965	JQ 1 98%	100MG	$40	2026-05-25	Buy

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Properties

Melting point :>205°C (dec.)
Boiling point :610.4±65.0 °C(Predicted)
Density :1.33
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :2.05±0.60(Predicted)
color :white to beige
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
InChIKey :DNVXATUJJDPFDM-KRWDZBQOSA-N
SMILES :N12C(C)=NN=C1[C@H](CC(OC(C)(C)C)=O)N=C(C1=CC=C(Cl)C=C1)C1C(C)=C(C)SC=12

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H332	Harmful if inhaled	Acute toxicity,inhalation	Category 4	Warning	P261, P271, P304+P340, P312
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The bromodomain and extra terminal domain (BET) family of proteins, including BRD2, BRD3, and BRD4, play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes. JQ1 displaces BET proteins from chromatin by competitively binding to the acetyl-lysine recognition pocket of BET bromodomains. Enantiomerically pure (+)-JQ1 binds to BRD4 bromodomains 1 and 2 with Kd values of ~50 and 90 nM, respectively, whereas the (?)-JQ1 stereoisomer has no appreciable affinity to BET bromodomains. JQ1 has been used as a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. See the Structural Genomics Consortium (SGC) website for more information.

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Suppliers and manufacturers

career henan chemical co

$1.00
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate CAS:1268524-70-4

Capot Chemical Co.,Ltd.

Nanjing ChemLin Chemical Industry Co., Ltd.

ATK CHEMICAL COMPANY LIMITED

Zhejiang ZETian Fine Chemicals Co. LTD

Biochempartner

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd.

Accela ChemBio Inc.

Shandong chuangyingchemical Co., Ltd.

Shochem(Shanghai) Co.,Ltd

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(+)-JQ-1

Properties

Safety Information

Description

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