Ponatinib
|
- $10 - $1963.5
- Product name: Ponatinib
- CAS: 943319-70-8
- MF: C29H27F3N6O
- MW: 532.56
- EINECS:1308068-626-2
- MDL Number:MFCD17215203
- Synonyms:AP24534(Ponatinib);AP24534;AP24534;PONATINIB;3-(IMIDAZO[1,2-B]PYRIDAZIN-3-YLETHYNYL)-4-METHYL-N-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)BENZAMIDE;Ponatinib;3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide;Ponatinib (AP24534);Ponatinib (with 4 ints.);3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
113 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Activate Scientific
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
- Usbiological
Package
- EvaluationSample
- 1mg
- 5mg
- 10mM(in1mLDMSO)
- 10mM*1mLinDMSO(Solid+Solvent)
- 10
- 1unit
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO
- 10mM(in 1mL DMSO)
- 10mg
- 20mg
- 25mg
- 50mg
- 2x25mg
- 100mg
- 100.00mg
- 200mg
- 250mg
- 250.00mg
- 500mg
- 1g
- 1.00g
- 2g
- 5G
- Manufactureraablocks
- Product numberAA0035YH
- Product description3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide 98%
- Packaging5mg
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0035YH
- Product description3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide 98%
- Packaging10mg
- Price$13
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0035YH
- Product description3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide 95%
- Packaging100mg
- Price$52
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0035YH
- Product description3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide 95%
- Packaging250mg
- Price$89
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0035YH
- Product description3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide 95%
- Packaging1g
- Price$233
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberI-9577
- Product descriptionPonatinib 98%
- Packaging5G
- Price$520
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberI-9577
- Product descriptionPonatinib 98%
- Packaging1G
- Price$170
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberI-9577
- Product descriptionPonatinib 98%
- Packaging100MG
- Price$40
- Updated2026-05-27
- Buy
- ManufacturerActivate Scientific
- Product numberAS10209
- Product descriptionPonatinib 95+%
- Packaging5mg
- Price$63
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS10209
- Product descriptionPonatinib 95+%
- Packaging1g
- Price$471
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS10209
- Product descriptionPonatinib 95+%
- Packaging250mg
- Price$225
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberCDX-P0911-M100
- Product descriptionPonatinib ≥98%(HPLC)
- Packaging100mg
- Price$275
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1116-M050
- Product descriptionPonatinib ≥95%
- Packaging50mg
- Price$394
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1116-M001
- Product descriptionPonatinib ≥95%
- Packaging1mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3538-M005
- Product descriptionPonatinib ≥98%
- Packaging5mg
- Price$45
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3538-M001
- Product descriptionPonatinib ≥98%
- Packaging1mg
- Price$25
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0035YH | 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide 98% | 5mg | $10 | 2026-05-28 | Buy |
| aablocks | AA0035YH | 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide 98% | 10mg | $13 | 2026-05-28 | Buy |
| aablocks | AA0035YH | 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide 95% | 100mg | $52 | 2026-05-28 | Buy |
| aablocks | AA0035YH | 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide 95% | 250mg | $89 | 2026-05-28 | Buy |
| aablocks | AA0035YH | 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzamide 95% | 1g | $233 | 2026-05-28 | Buy |
| ACHEMBLOCK | I-9577 | Ponatinib 98% | 5G | $520 | 2026-05-27 | Buy |
| ACHEMBLOCK | I-9577 | Ponatinib 98% | 1G | $170 | 2026-05-27 | Buy |
| ACHEMBLOCK | I-9577 | Ponatinib 98% | 100MG | $40 | 2026-05-27 | Buy |
| Activate Scientific | AS10209 | Ponatinib 95+% | 5mg | $63 | 2021-12-16 | Buy |
| Activate Scientific | AS10209 | Ponatinib 95+% | 1g | $471 | 2021-12-16 | Buy |
| Activate Scientific | AS10209 | Ponatinib 95+% | 250mg | $225 | 2021-12-16 | Buy |
| Adipogen Life Sciences | CDX-P0911-M100 | Ponatinib ≥98%(HPLC) | 100mg | $275 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1116-M050 | Ponatinib ≥95% | 50mg | $394 | 2021-12-16 | Buy |
| Adipogen Life Sciences | SYN-1116-M001 | Ponatinib ≥95% | 1mg | $65 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3538-M005 | Ponatinib ≥98% | 5mg | $45 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3538-M001 | Ponatinib ≥98% | 1mg | $25 | 2021-12-16 | Buy |
Properties
Melting point :>175°C (dec.)
Density :1.3
storage temp. :-20°C
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
form :Yellow powder.
pka :12.99±0.70(Predicted)
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :PHXJVRSECIGDHY-UHFFFAOYSA-N
SMILES :C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)(=O)C1=CC=C(C)C(C#CC2N3C(=NC=2)C=CC=N3)=C1
CAS DataBase Reference :943319-70-8
Density :1.3
storage temp. :-20°C
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming).
form :Yellow powder.
pka :12.99±0.70(Predicted)
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :PHXJVRSECIGDHY-UHFFFAOYSA-N
SMILES :C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)(=O)C1=CC=C(C)C(C#CC2N3C(=NC=2)C=CC=N3)=C1
CAS DataBase Reference :943319-70-8
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | ||||||||||||||
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Description
Ponatinib is an orally available, pan-Bcr-Abl tyrosine kinase inhibitor developed for the treatment of an advanced phase of chronic myeloid leukemia in which mutations of the kinase endow resistance to other Bcr-Abl inhibitors. Ponatinib potently inhibits native Bcr-Abl (IC50 = 0.37 nM) as well as various clinically important mutant forms including Bcr-AblT315I (IC50 = 2 nM). It can also inhibit c-Src (IC50 = 5.4 nM) and VEGFR, FGFR, and PDGFR receptor tyrosine kinases (IC50s = 1-2 nM), yet is >1,000-fold selective against family members of Aurora kinase, insulin receptor kinase, or cyclin-dependent kinase. Ponatinib has been shown to inhibit proliferation of Ba/F3 cells expressing native (IC50 = 0.5 nM) or mutant (IC50s = 0.5-36 nM) Bcr-Abl by inducing apoptosis. In a Ba/F3 Bcr- AblT315I xenograft model, tumor growth was inhibited in mice upon oral dosing at 10-30 mg/kg.Related product price
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Suppliers and manufacturers
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Biochempartner
Ponatinib
CAS:943319-70-8
