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ChemicalBook >> CAS DataBase List >> LONAFARNIB

LONAFARNIB

LONAFARNIB price.
  • $21 - $11550
  • Product name: LONAFARNIB
  • CAS: 193275-84-2
  • MF: C27H31Br2ClN4O2
  • MW: 638.82
  • EINECS:
  • MDL Number:MFCD06795138
  • Synonyms:LONAFARNIB;4-(2-(4-((R)-3,10-dibroMo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)cyclohexyl)-2-oxoethyl)piperidine-1-carboxaMide;Lonafarnib (SCH66336);1-Piperidinecarboxamide, 4-(2-(4-((11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo(5,6)cyclohepta(1,2-B)pyridin-11-yl)-1-piperidinyl)-2-oxoethyl)-;4-(2-(4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo-(5,6)-cyclohepta(1,2-B)-pyridin-11(R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide;Lonafarnib [usan];Sarasar;Sch 66336
75 prices
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Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 1mg
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  • 10mM*1mLinDMSO
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  • 1G
  • 10mM(in1mLDMSO)
  • 10mM*1mLinDMSO(Solution)
  • 1000mg
  • Manufactureraablocks
  • Product numberAA00ABHU
  • Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 98%
  • Packaging1mg
  • Price$21
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00ABHU
  • Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 98%
  • Packaging5mg
  • Price$64
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00ABHU
  • Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 98%
  • Packaging10mg
  • Price$95
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00ABHU
  • Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 98%
  • Packaging25mg
  • Price$151
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00ABHU
  • Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 98%
  • Packaging50mg
  • Price$251
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00ABHU
  • Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 98%
  • Packaging100mg
  • Price$388
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product number10424
  • Product descriptionLonafarnib 98%
  • Packaging100MG
  • Price$625
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product number10424
  • Product descriptionLonafarnib 98%
  • Packaging25MG
  • Price$245
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product number10424
  • Product descriptionLonafarnib 98%
  • Packaging5MG
  • Price$80
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  • ManufacturerACHEMBLOCK
  • Product number10424
  • Product descriptionLonafarnib 98%
  • Packaging1G
  • Price$3550
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product numberY0240
  • Product descriptionLonafarnib
  • Packaging5mg
  • Price$167
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA257211
  • Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+%
  • Packaging10mg
  • Price$221
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA257211
  • Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+%
  • Packaging5mg
  • Price$122
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA257211
  • Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+%
  • Packaging1mg
  • Price$72
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA257211
  • Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+%
  • Packaging100mg
  • Price$708
  • Updated2021-12-16
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  • ManufacturerAmbeed
  • Product numberA257211
  • Product description(R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+%
  • Packaging250mg
  • Price$1523
  • Updated2021-12-16
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Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00ABHU (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 98% 1mg $21 2026-05-28 Buy
aablocks AA00ABHU (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 98% 5mg $64 2026-05-28 Buy
aablocks AA00ABHU (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 98% 10mg $95 2026-05-28 Buy
aablocks AA00ABHU (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 98% 25mg $151 2026-05-28 Buy
aablocks AA00ABHU (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 98% 50mg $251 2026-05-28 Buy
aablocks AA00ABHU (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 98% 100mg $388 2026-05-28 Buy
ACHEMBLOCK 10424 Lonafarnib 98% 100MG $625 2026-05-27 Buy
ACHEMBLOCK 10424 Lonafarnib 98% 25MG $245 2026-05-27 Buy
ACHEMBLOCK 10424 Lonafarnib 98% 5MG $80 2026-05-27 Buy
ACHEMBLOCK 10424 Lonafarnib 98% 1G $3550 2026-05-27 Buy
AK Scientific Y0240 Lonafarnib 5mg $167 2021-12-16 Buy
Ambeed A257211 (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+% 10mg $221 2021-12-16 Buy
Ambeed A257211 (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+% 5mg $122 2021-12-16 Buy
Ambeed A257211 (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+% 1mg $72 2021-12-16 Buy
Ambeed A257211 (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+% 100mg $708 2021-12-16 Buy
Ambeed A257211 (R)-4-(2-(4-(3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl)-2-oxoethyl)piperidine-1-carboxamide 99+% 250mg $1523 2021-12-16 Buy

Properties

Melting point :214.5-215.9° (monohydrate); mp 222-223°
alpha :D25 = +49.1° (c = 0.21 in methanol)
Boiling point :710.4±70.0 °C(Predicted)
Density :1.536
storage temp. :-20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
form :powder
pka :15.76±0.40(Predicted)
color :white to beige
InChIKey :DHMTURDWPRKSOA-RUZDIDTESA-N
SMILES :O=C(N)N(CC1)CCC1CC(N2CCC([C@H]3C(N=CC(Br)=C4)=C4CCC5=C3C(Br)=CC(Cl)=C5)CC2)=O

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Farnesyl transferase drives the post-translational farnesylation of a number of target proteins, including Ras, a component of the MAPK and Akt signaling pathways involved in cell proliferation, and Ras homolog enriched in brain (Rheb), which stimulates mTOR activity. By arresting growth, farnesyl transferase inhibitors have great potential as antitumor agents. Lonafarnib is a farnesyl transferase inhibitor that blocks the post-translational lipid modification of oncogenic Ras isoforms H-Ras, N-Ras, and K-Ras (IC50s = 1.9, 2.8, and 5.2 nM, respectively) as well as Rheb (IC50 = 10-100 nM). It inhibits H-Ras signaling in whole cells (IC50 = 10 nM) and blocks the transformed growth properties of fibroblasts (IC50 = 75 nM) and human tumor cell lines (IC50 = 400 nM) expressing activated K-Ras proteins. In the nude mouse, lonafarnib demonstrates potent dose-dependent oral activity in an array of human tumor xenograft models including tumors originating from colon, lung, pancreas, prostate, and urinary bladder. Combination treatments with various cytotoxic agents (cyclophosphamide, 5-fluorouracil, and vincristine) or MAPK or Akt pathway inhibitors can enhance the in vivo efficacy of lonafarib.

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