Linifanib (ABT-869)
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- $18 - $2654
- Product name: Linifanib (ABT-869)
- CAS: 796967-16-3
- MF: C21H18FN5O
- MW: 375.4
- EINECS:
- MDL Number:MFCD11840918
- Synonyms:1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea;N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea;N-(4-(3-Amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea;Urea, N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)-;ABT-869 5.2G;AL-39324;RG3635;ABT-869/Linifanib
83 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TCI Chemical
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO
- 5mg
- 10mM*1mLinDMSO(Solution)
- 1mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 500mg
- 1.00g
- 1g
- 5g
- 10mM(in1mLDMSO)
- 10mM(in 1mL DMSO)
- Manufactureraablocks
- Product numberAA0036F1
- Product descriptionN-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 98+%
- Packaging10mg
- Price$53
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036F1
- Product descriptionN-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 98+%
- Packaging50mg
- Price$127
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036F1
- Product descriptionN-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 96%
- Packaging100mg
- Price$129
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036F1
- Product descriptionN-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 96
- Packaging25mg
- Price$123
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036F1
- Product descriptionN-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 98+%
- Packaging5mg
- Price$29
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036F1
- Product descriptionN-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 98+%
- Packaging1mg
- Price$18
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036F1
- Product descriptionN-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 96%
- Packaging250mg
- Price$240
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036F1
- Product descriptionN-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 96%
- Packaging1g
- Price$668
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0036F1
- Product descriptionN-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 96%
- Packaging5g
- Price$2654
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15676
- Product descriptionABT-869 98%
- Packaging1G
- Price$536
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15676
- Product descriptionABT-869 98%
- Packaging25MG
- Price$41
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15676
- Product descriptionABT-869 98%
- Packaging100MG
- Price$99
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1002-M001
- Product descriptionLinifanib ≥95%
- Packaging1mg
- Price$86
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1002-M010
- Product descriptionLinifanib ≥95%
- Packaging10mg
- Price$216
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1002-M005
- Product descriptionLinifanib ≥95%
- Packaging5mg
- Price$130
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1002-M050
- Product descriptionLinifanib ≥95%
- Packaging50mg
- Price$594
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0036F1 | N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 98+% | 10mg | $53 | 2026-05-28 | Buy |
| aablocks | AA0036F1 | N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 98+% | 50mg | $127 | 2026-05-28 | Buy |
| aablocks | AA0036F1 | N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 96% | 100mg | $129 | 2026-05-28 | Buy |
| aablocks | AA0036F1 | N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 96 | 25mg | $123 | 2026-05-28 | Buy |
| aablocks | AA0036F1 | N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 98+% | 5mg | $29 | 2026-05-28 | Buy |
| aablocks | AA0036F1 | N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 98+% | 1mg | $18 | 2026-05-28 | Buy |
| aablocks | AA0036F1 | N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 96% | 250mg | $240 | 2026-05-28 | Buy |
| aablocks | AA0036F1 | N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 96% | 1g | $668 | 2026-05-28 | Buy |
| aablocks | AA0036F1 | N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea 96% | 5g | $2654 | 2026-05-28 | Buy |
| ACHEMBLOCK | M15676 | ABT-869 98% | 1G | $536 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15676 | ABT-869 98% | 25MG | $41 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15676 | ABT-869 98% | 100MG | $99 | 2026-05-27 | Buy |
| Adipogen Life Sciences | SYN-1002-M001 | Linifanib ≥95% | 1mg | $86 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1002-M010 | Linifanib ≥95% | 10mg | $216 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1002-M005 | Linifanib ≥95% | 5mg | $130 | 2026-05-06 | Buy |
| Adipogen Life Sciences | SYN-1002-M050 | Linifanib ≥95% | 50mg | $594 | 2026-05-06 | Buy |
Properties
Melting point :180-183°C (dec.)
Boiling point :542.2±50.0 °C(Predicted)
Density :1.424
storage temp. :-20°C Freezer
solubility :DMSO, Methanol
pka :13.30±0.70(Predicted)
form :Brown powder.
color :Beige
InChI :InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
InChIKey :MPVGZUGXCQEXTM-UHFFFAOYSA-N
SMILES :N(C1=CC=C(C2=CC=CC3=C2C(N)=NN3)C=C1)C(NC1=CC(C)=CC=C1F)=O
Boiling point :542.2±50.0 °C(Predicted)
Density :1.424
storage temp. :-20°C Freezer
solubility :DMSO, Methanol
pka :13.30±0.70(Predicted)
form :Brown powder.
color :Beige
InChI :InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
InChIKey :MPVGZUGXCQEXTM-UHFFFAOYSA-N
SMILES :N(C1=CC=C(C2=CC=CC3=C2C(N)=NN3)C=C1)C(NC1=CC(C)=CC=C1F)=O
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | |||||||||||||||||||||||||||||||||||
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Description
Receptor tyrosine kinases (RTKs) mediate critical signaling transduction pathways important for cell survival, growth, and differentiation. Whereas aberrant tyrosine kinase signaling is correlated with the progression of various cancers, RTK inhibitors are useful as cancer therapy agents. ABT-869 is an ATP-competitive, multi-targeted RTK inhibitor that is completely effective against all members of the vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) receptor families (e.g., KDR, FLT1, FLT3, FLT4, CSF-1R, and KIT) demonstrating IC50 values ranging from 4-190 nM. ABT-869 shows little activity against unrelated RTKs, cytoplasmic tyrosine kinases, or Ser/Thr kinases (IC50s > 1 μM). ABT-869 inhibits proliferation in MV-4-11 and MOLM-13 cells (acute myeloid leukemia cell lines harboring RTK mutations; IC50s = 4 and 6 nM, respectively), inducing apoptosis as evidenced by an increased sub-G0/G1 phase cell population, caspase activation, and PARP cleavage. In murine xenograft models, as well as in a phase 1 clinical trial, ABT-869 demonstrated respectable efficacy in solid tumors including lung and hepatocellular carcinomas.More related product prices
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