Lomitapide
|
- $23 - $1500
- Product name: Lomitapide
- CAS: 182431-12-5
- MF: C39H37F6N3O2
- MW: 693.72
- EINECS:
- MDL Number:MFCD16620494
- Synonyms:N-(2,2,2-Trifluoroethyl)-9-(4-[4-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]piperidin-1-yl]butyl)-9H-fluorene-9-carboxamide;N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9-carboxamide;AEGR 733;BMS 201038;BMS 201038-01;BMS 201238;LoMitapide;N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoroMethyl)biphenyl-2-ylcarboxaMido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxaMide
65 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Cayman Chemical
- Chem-Impex
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- 5mg
- 200mg
- 500mg
- 10mM(1mLinDMSO)
- 10mM*1mLinDMSO
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM(in1mLDMSO)
- 1mg
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA0023ST
- Product descriptionLomitapide ≥98%(HPLC)
- Packaging50mg
- Price$41
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0023ST
- Product descriptionLomitapide ≥98%(HPLC)
- Packaging250mg
- Price$153
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0023ST
- Product descriptionLomitapide ≥98%(HPLC)
- Packaging25mg
- Price$23
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0023ST
- Product descriptionLomitapide ≥98%(HPLC)
- Packaging1g
- Price$407
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberL13802
- Product descriptionLomitapide 98%
- Packaging1G
- Price$370
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberL13802
- Product descriptionLomitapide 98%
- Packaging100MG
- Price$68
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberZ1876
- Product descriptionLomitapide
- Packaging1mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberZ1876
- Product descriptionLomitapide
- Packaging10mg
- Price$336
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001125
- Product descriptionBMS-201038 95.00%
- Packaging1MG
- Price$159.6
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4885
- Product descriptionLomitapide
- Packaging10mM(in1mLDMSO)
- Price$77
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4885
- Product descriptionLomitapide
- Packaging5mg
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4885
- Product descriptionLomitapide
- Packaging25mg
- Price$220
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4885
- Product descriptionLomitapide
- Packaging100mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4885
- Product descriptionLomitapide
- Packaging100mg
- Price$605
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-14667
- Product descriptionLomitapide 99.63%
- Packaging100mg
- Price$608
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-14667
- Product descriptionLomitapide 99.63%
- Packaging200mg
- Price$896
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0023ST | Lomitapide ≥98%(HPLC) | 50mg | $41 | 2026-05-28 | Buy |
| aablocks | AA0023ST | Lomitapide ≥98%(HPLC) | 250mg | $153 | 2026-05-28 | Buy |
| aablocks | AA0023ST | Lomitapide ≥98%(HPLC) | 25mg | $23 | 2026-05-28 | Buy |
| aablocks | AA0023ST | Lomitapide ≥98%(HPLC) | 1g | $407 | 2026-05-28 | Buy |
| ACHEMBLOCK | L13802 | Lomitapide 98% | 1G | $370 | 2026-05-27 | Buy |
| ACHEMBLOCK | L13802 | Lomitapide 98% | 100MG | $68 | 2026-05-27 | Buy |
| AK Scientific | Z1876 | Lomitapide | 1mg | $133 | 2021-12-16 | Buy |
| AK Scientific | Z1876 | Lomitapide | 10mg | $336 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001125 | BMS-201038 95.00% | 1MG | $159.6 | 2021-12-16 | Buy |
| ApexBio Technology | B4885 | Lomitapide | 10mM(in1mLDMSO) | $77 | 2026-05-06 | Buy |
| ApexBio Technology | B4885 | Lomitapide | 5mg | $55 | 2026-05-06 | Buy |
| ApexBio Technology | B4885 | Lomitapide | 25mg | $220 | 2026-05-06 | Buy |
| ApexBio Technology | B4885 | Lomitapide | 100mg | $550 | 2021-12-16 | Buy |
| ApexBio Technology | B4885 | Lomitapide | 100mg | $605 | 2026-05-06 | Buy |
| Arctom | HY-14667 | Lomitapide 99.63% | 100mg | $608 | 2026-05-26 | Buy |
| Arctom | HY-14667 | Lomitapide 99.63% | 200mg | $896 | 2026-05-26 | Buy |
Properties
Melting point :142°C(lit.)
Boiling point :778.2±60.0 °C(Predicted)
Density :1.34±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :12.66±0.20(Predicted)
form :powder
color :white to beige
InChIKey :MBBCVAKAJPKAKM-UHFFFAOYSA-N
SMILES :O=C(NCC(F)(F)F)C1(C(C=CC=C2)=C2C3=C1C=CC=C3)CCCCN(CC4)CCC4NC(C5=C(C6=CC=C(C(F)(F)F)C=C6)C=CC=C5)=O
Boiling point :778.2±60.0 °C(Predicted)
Density :1.34±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :12.66±0.20(Predicted)
form :powder
color :white to beige
InChIKey :MBBCVAKAJPKAKM-UHFFFAOYSA-N
SMILES :O=C(NCC(F)(F)F)C1(C(C=CC=C2)=C2C3=C1C=CC=C3)CCCCN(CC4)CCC4NC(C5=C(C6=CC=C(C(F)(F)F)C=C6)C=CC=C5)=O
Safety Information
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| Signal word: | warning | ||||||||||||||||||||||||||||||||
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Description
Lomitapide was approved by the US FDA in December 2012 for the treatment of patients with familial hypercholesteremia (referred to as HoFH) in conjunction with a low-fat diet andother lipid-lowering treatments. Lomitapide was discovered from a high-through put screen that identified several structurally distinct MTP inhibitors. Combination of key structural features from two structurally distinct HTS hits provided potent MTP inhibitors. Parallel analog synthesis led to lomitapide as an optimized structure. Lomitapide was synthesized via alkylation of 9-fluorenylcarboxylic acid with 1,4-dibromobutane which, after trifluoroethylamide formation, provided a bromide intermediate that was displaced by Boc-4-aminopiperidine. Introduction of the 4'-trifluoromethylbiphenylcarboxamide gave lomitapide, which was found to inhibit MTP with an IC50 of 0.5 nM and to exhibit good cholesterol-lowering efficacy in Sprague–Dawley rats (intravenous and oral ED50～0.2 mg/kg).Related product price
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Lomitapide
CAS:182431-12-5
