ML414(NGI-1)
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- $13 - $3894
- Product name: ML414(NGI-1)
- CAS: 790702-57-7
- MF: C17H22N4O3S2
- MW: 394.51
- EINECS:-0
- MDL Number:MFCD06358908
- Synonyms:Benzamide, 5-[(dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)-;NGI-1 >=95% (HPLC);
5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benz amide;ML414(NGI-1);ML414;NGI-1; NGI1; NGI 1; ML414; ML 414; ML-414、;NGI-1 (ML414);5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide
71 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 10mM(1mLinDMSO)
- 1mg
- 25
- 5mg
- 10mg
- 25mg
- 5
- 50MG
- 100MG
- 0.1g
- 250mg
- 0.5g
- 1g
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- Manufactureraablocks
- Product numberAA01BEK5
- Product descriptionNGI-1 99%
- Packaging1mg
- Price$13
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01BEK5
- Product descriptionNGI-1 99%
- Packaging5mg
- Price$25
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01BEK5
- Product descriptionNGI-1 99%
- Packaging10mg
- Price$35
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA01BEK5
- Product descriptionNGI-1 99%
- Packaging25mg
- Price$58
- Updated2026-05-29
- Buy
- ManufacturerACHEMBLOCK
- Product numberY229209
- Product descriptionNGI-1 97.00%
- Packaging50MG
- Price$160
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY229209
- Product descriptionNGI-1 97.00%
- Packaging100MG
- Price$290
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number0238CH
- Product description5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-ylbenzamide
- Packaging10mg
- Price$178
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA956586
- Product descriptionNGI-1 99%
- Packaging100mg
- Price$191
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA956586
- Product descriptionNGI-1 99%
- Packaging50mg
- Price$123
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA956586
- Product descriptionNGI-1 99%
- Packaging10mg
- Price$44
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA956586
- Product descriptionNGI-1 99%
- Packaging5mg
- Price$31
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA956586
- Product descriptionNGI-1 99%
- Packaging1mg
- Price$16
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA956586
- Product descriptionNGI-1 99%
- Packaging25mg
- Price$73
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA956586
- Product descriptionNGI-1 99%
- Packaging1g
- Price$871
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA956586
- Product descriptionNGI-1 99%
- Packaging250mg
- Price$323
- Updated2026-06-05
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0009737
- Product descriptionNGI1 95.00%
- Packaging5MG
- Price$451.85
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA01BEK5 | NGI-1 99% | 1mg | $13 | 2026-05-29 | Buy |
| aablocks | AA01BEK5 | NGI-1 99% | 5mg | $25 | 2026-05-29 | Buy |
| aablocks | AA01BEK5 | NGI-1 99% | 10mg | $35 | 2026-05-29 | Buy |
| aablocks | AA01BEK5 | NGI-1 99% | 25mg | $58 | 2026-05-29 | Buy |
| ACHEMBLOCK | Y229209 | NGI-1 97.00% | 50MG | $160 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y229209 | NGI-1 97.00% | 100MG | $290 | 2026-05-27 | Buy |
| AK Scientific | 0238CH | 5-(Dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-pyrrolidin-1-ylbenzamide | 10mg | $178 | 2021-12-16 | Buy |
| Ambeed | A956586 | NGI-1 99% | 100mg | $191 | 2026-06-05 | Buy |
| Ambeed | A956586 | NGI-1 99% | 50mg | $123 | 2026-06-05 | Buy |
| Ambeed | A956586 | NGI-1 99% | 10mg | $44 | 2026-06-05 | Buy |
| Ambeed | A956586 | NGI-1 99% | 5mg | $31 | 2026-06-05 | Buy |
| Ambeed | A956586 | NGI-1 99% | 1mg | $16 | 2026-06-05 | Buy |
| Ambeed | A956586 | NGI-1 99% | 25mg | $73 | 2026-06-05 | Buy |
| Ambeed | A956586 | NGI-1 99% | 1g | $871 | 2026-06-05 | Buy |
| Ambeed | A956586 | NGI-1 99% | 250mg | $323 | 2026-06-05 | Buy |
| American Custom Chemicals Corporation | INB0009737 | NGI1 95.00% | 5MG | $451.85 | 2021-12-16 | Buy |
Properties
Density :1.372±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 5 mg/ml)
pka :7.48±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :QPKGRLIYJGBKJL-UHFFFAOYSA-N
SMILES :[S](=O)(=O)(N(C)C)c1cc(c(cc1)N3CCCC3)C(=O)Nc2[s]c(cn2)C
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 5 mg/ml)
pka :7.48±0.50(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :QPKGRLIYJGBKJL-UHFFFAOYSA-N
SMILES :[S](=O)(=O)(N(C)C)c1cc(c(cc1)N3CCCC3)C(=O)Nc2[s]c(cn2)C
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
NGI-1 (790702-57-7) is a cell-permeable inhibitor of oligosaccharyltransferase (OST) – IC50 = 1.1 μM.1 It blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein and selectively arrests proliferation only in cells dependent on EGFR for survival. NGI-1 caused G1 arrest and senescence in RTK-dependent NSCLC cells (PC9, HCC827, H3255,H1581). NGI-1 displays antiviral behavior against various flaviviruses (Dengue, West Nile, Yellow fever and Zika).2 It also was able to overcome resistance to EGFR tyrosine kinase inhibitors in mutant NSCLC cells3 and enhance radiosensitivity and cytotoxic effects of chemotherapy in glioma cells with high levels of RTK activation4.Related product price
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