Methotrexate
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- $8 - $12270
- Product name: Methotrexate
- CAS: 59-05-2
- MF: C20H22N8O5
- MW: 454.44
- EINECS:200-413-8
- MDL Number:MFCD00064370
- Synonyms:METHOTREXATEFORINJECTION;METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID);4-Amino-N10-methylfolic acid;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI);L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI);L-Methotrexate;Methotrexat-Ebewe;METHOTREXATEC
121 prices
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Brand
- aablocks
- AccelPharmtech
- Acrotein
- Activate Scientific
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- AstaTech
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Chemtos
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Thermo Scientific Chemicals
- Tocris
- TRC
- Usbiological
Package
- 2x50mg
- 2g
- 5ml
- 10/ G
- 0.25G
- 10mM*1mLinDMSO(Solution)
- 2*25/ G
- 5/ G
- 1mL
- 50g
- 100
- m1000000
- 20 mg
- y0001668
- y0000602
- 100 mg
- 10mM(in 1mL DMSO)
- 1mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100MG
- 10mM*1mLinDMSO(Solid+Solvent)
- 200mg
- 250mg
- 500mg
- 1g
- 5g
- 10g
- 25g
- 100g
- Manufactureraablocks
- Product numberAA0039N6
- Product description(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid 99%(contain~10%water)
- Packaging1mg
- Price$9
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039N6
- Product description(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid 96%
- Packaging1g
- Price$15
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039N6
- Product description(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid 99%(contain~10%water)
- Packaging5g
- Price$42
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039N6
- Product description(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid 99%(contain~10%water)
- Packaging10g
- Price$68
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0039N6
- Product description(S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid 99%(contain~10%water)
- Packaging25g
- Price$133
- Updated2026-05-28
- Buy
- ManufacturerAccelPharmtech
- Product numberZQ1052
- Product descriptionMethotrexate 99%
- Packaging10G
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerAccelPharmtech
- Product numberZQ1052
- Product descriptionMethotrexate 99%
- Packaging10G
- Price$250
- Updated2026-05-21
- Buy
- ManufacturerAccelPharmtech
- Product numberZQ1052
- Product descriptionMethotrexate 99%
- Packaging5G
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerAccelPharmtech
- Product numberZQ1052
- Product descriptionMethotrexate 99%
- Packaging5G
- Price$200
- Updated2026-05-21
- Buy
- ManufacturerAcrotein
- Product numberdm-0144
- Product descriptionMethotrexate 97%
- Packaging100g
- Price$594
- Updated2026-05-25
- Buy
- ManufacturerAcrotein
- Product numberDM-0144
- Product descriptionMethotrexate 97%
- Packaging25g
- Price$198
- Updated2021-12-16
- Buy
- ManufacturerAcrotein
- Product numberdm-0144
- Product descriptionMethotrexate 97%
- Packaging25g
- Price$198
- Updated2026-05-25
- Buy
- ManufacturerAcrotein
- Product numberdm-0144
- Product descriptionMethotrexate 97%
- Packaging5g
- Price$66
- Updated2026-05-25
- Buy
- ManufacturerActivate Scientific
- Product numberAS110159-A
- Product descriptionMethotrexate 99%
- Packaging250mg
- Price$34
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS110159-A
- Product descriptionMethotrexate 99%
- Packaging1g
- Price$68
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS110159-A
- Product descriptionMethotrexate 99%
- Packaging5G
- Price$176
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0039N6 | (S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid 99%(contain~10%water) | 1mg | $9 | 2026-05-28 | Buy |
| aablocks | AA0039N6 | (S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid 96% | 1g | $15 | 2026-05-28 | Buy |
| aablocks | AA0039N6 | (S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid 99%(contain~10%water) | 5g | $42 | 2026-05-28 | Buy |
| aablocks | AA0039N6 | (S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid 99%(contain~10%water) | 10g | $68 | 2026-05-28 | Buy |
| aablocks | AA0039N6 | (S)-2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid 99%(contain~10%water) | 25g | $133 | 2026-05-28 | Buy |
| AccelPharmtech | ZQ1052 | Methotrexate 99% | 10G | $250 | 2021-12-16 | Buy |
| AccelPharmtech | ZQ1052 | Methotrexate 99% | 10G | $250 | 2026-05-21 | Buy |
| AccelPharmtech | ZQ1052 | Methotrexate 99% | 5G | $200 | 2021-12-16 | Buy |
| AccelPharmtech | ZQ1052 | Methotrexate 99% | 5G | $200 | 2026-05-21 | Buy |
| Acrotein | dm-0144 | Methotrexate 97% | 100g | $594 | 2026-05-25 | Buy |
| Acrotein | DM-0144 | Methotrexate 97% | 25g | $198 | 2021-12-16 | Buy |
| Acrotein | dm-0144 | Methotrexate 97% | 25g | $198 | 2026-05-25 | Buy |
| Acrotein | dm-0144 | Methotrexate 97% | 5g | $66 | 2026-05-25 | Buy |
| Activate Scientific | AS110159-A | Methotrexate 99% | 250mg | $34 | 2021-12-16 | Buy |
| Activate Scientific | AS110159-A | Methotrexate 99% | 1g | $68 | 2021-12-16 | Buy |
| Activate Scientific | AS110159-A | Methotrexate 99% | 5G | $176 | 2021-12-16 | Buy |
Properties
Melting point :195°C
Boiling point :561.26°C (rough estimate)
alpha :+17～+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis)
Density :1.4080 (rough estimate)
refractive index :1.6910 (estimate)
Flash point :11℃
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :H2O: insoluble
form :powder
pka :pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)
color :Light yellow to yellow
biological source :synthetic
optical activity :Consistent with structure
Water Solubility :Insoluble. <0.1 g/100 mL at 19 ºC
Sensitive :Light Sensitive & Hygroscopic
Merck :14,5985
BRN :70669
BCS Class :3
Stability :Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.
Major Application :pharmaceutical (small molecule)
InChIKey :FBOZXECLQNJBKD-ZDUSSCGKSA-N
SMILES :CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
CAS DataBase Reference :59-05-2(CAS DataBase Reference)
IARC :3 (Vol. 26, Sup 7) 1987
NIST Chemistry Reference :Methotrexate(59-05-2)
EPA Substance Registry System :Methotrexate (59-05-2)
Boiling point :561.26°C (rough estimate)
alpha :+17～+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis)
Density :1.4080 (rough estimate)
refractive index :1.6910 (estimate)
Flash point :11℃
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :H2O: insoluble
form :powder
pka :pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)
color :Light yellow to yellow
biological source :synthetic
optical activity :Consistent with structure
Water Solubility :Insoluble. <0.1 g/100 mL at 19 ºC
Sensitive :Light Sensitive & Hygroscopic
Merck :14,5985
BRN :70669
BCS Class :3
Stability :Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.
Major Application :pharmaceutical (small molecule)
InChIKey :FBOZXECLQNJBKD-ZDUSSCGKSA-N
SMILES :CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
CAS DataBase Reference :59-05-2(CAS DataBase Reference)
IARC :3 (Vol. 26, Sup 7) 1987
NIST Chemistry Reference :Methotrexate(59-05-2)
EPA Substance Registry System :Methotrexate (59-05-2)
Safety Information
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Description
Methotrexate (MTX) is an analog of folic acid and aminopterin that is used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid and blocking key enzymes in the synthesis of purines and pyrimidines required for cell proliferation. MTX is known to induce adenosine release, which mediates many of its anti-inflammatory effects including the reduction of proinflammatory cytokines. MTX is still considered the gold standard of DMARD (disease-modifying antirheumatic drug) therapy to treat both the immune-inflammatory and joint destructive processes of rheumatoid arthritis.More related product prices
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Suppliers and manufacturers
Shaanxi TNJONE Pharmaceutical Co., Ltd
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