OSI-420
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- $59 - $2772
- Product name: OSI-420
- CAS: 183321-86-0
- MF: C21H21N3O4
- MW: 379.41
- EINECS:
- MDL Number:MFCD09841129
- Synonyms:CP 373420;OSI-420 (free base);Erlotinib O-DesMethyl Metabolite;Erlotinib iMpurity H;Desmethyl Erlotinib (CP-473420, OSI-420);6-O-Desmethyl Erlotinib 1;2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethan-1-ol;2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
46 prices
Selected condition：
Brand
- aablocks
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- TRC
- Usbiological
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging25mg
- Price$300
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging50mg
- Price$439
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging100mg
- Price$626
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging10mg
- Price$179
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging5mg
- Price$114
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging2mg
- Price$76
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0027F3
- Product description2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
- Packaging1mg
- Price$59
- Updated2026-05-28
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0152394
- Product description2-(4-(3-ETHYNYLPHENYLAMINO)-7-(2-METHOXYETHOXY)QUINAZOLIN-6-YLOXY)ETHANOL 95.00%
- Packaging10MG
- Price$2728.69
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0152394
- Product description2-(4-(3-ETHYNYLPHENYLAMINO)-7-(2-METHOXYETHOXY)QUINAZOLIN-6-YLOXY)ETHANOL 95.00%
- Packaging1MG
- Price$818.61
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1495
- Product descriptionOSI-420 free base
- Packaging50mg
- Price$647
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1495
- Product descriptionOSI-420freebase
- Packaging200mg
- Price$2006
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1495
- Product descriptionOSI-420 free base
- Packaging200mg
- Price$2006
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1495
- Product descriptionOSI-420 free base
- Packaging5mg
- Price$120
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1495
- Product descriptionOSI-420 free base
- Packaging10mg
- Price$210
- Updated2026-05-06
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1632
- Product descriptionOSI 420
- Packaging2mg
- Price$99
- Updated2026-05-19
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1632
- Product descriptionOSI 420
- Packaging5mg
- Price$148.5
- Updated2026-05-19
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 25mg | $300 | 2026-05-28 | Buy |
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 50mg | $439 | 2026-05-28 | Buy |
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 100mg | $626 | 2026-05-28 | Buy |
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 10mg | $179 | 2026-05-28 | Buy |
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 5mg | $114 | 2026-05-28 | Buy |
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 2mg | $76 | 2026-05-28 | Buy |
| aablocks | AA0027F3 | 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol | 1mg | $59 | 2026-05-28 | Buy |
| American Custom Chemicals Corporation | CHM0152394 | 2-(4-(3-ETHYNYLPHENYLAMINO)-7-(2-METHOXYETHOXY)QUINAZOLIN-6-YLOXY)ETHANOL 95.00% | 10MG | $2728.69 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0152394 | 2-(4-(3-ETHYNYLPHENYLAMINO)-7-(2-METHOXYETHOXY)QUINAZOLIN-6-YLOXY)ETHANOL 95.00% | 1MG | $818.61 | 2021-12-16 | Buy |
| ApexBio Technology | B1495 | OSI-420 free base | 50mg | $647 | 2026-05-06 | Buy |
| ApexBio Technology | B1495 | OSI-420freebase | 200mg | $2006 | 2021-12-16 | Buy |
| ApexBio Technology | B1495 | OSI-420 free base | 200mg | $2006 | 2026-05-06 | Buy |
| ApexBio Technology | B1495 | OSI-420 free base | 5mg | $120 | 2026-05-06 | Buy |
| ApexBio Technology | B1495 | OSI-420 free base | 10mg | $210 | 2026-05-06 | Buy |
| Axon Medchem | Axon1632 | OSI 420 | 2mg | $99 | 2026-05-19 | Buy |
| Axon Medchem | Axon1632 | OSI 420 | 5mg | $148.5 | 2026-05-19 | Buy |
Properties
Melting point :140-142°C
Density :1.30
storage temp. :-20°C Freezer
solubility :insoluble in H2O; insoluble in EtOH; ≥51 mg/mL in DMSO
form :A crystalline solid
color :White to off-white
InChI :InChI=1S/C21H21N3O4/c1-3-15-5-4-6-16(11-15)24-21-17-12-19(27-8-7-25)20(28-10-9-26-2)13-18(17)22-14-23-21/h1,4-6,11-14,25H,7-10H2,2H3,(H,22,23,24)
InChIKey :KOQIAZNBAWFSQM-UHFFFAOYSA-N
SMILES :C(O)COC1C(OCCOC)=CC2C(C=1)=C(NC1=CC=CC(C#C)=C1)N=CN=2
Density :1.30
storage temp. :-20°C Freezer
solubility :insoluble in H2O; insoluble in EtOH; ≥51 mg/mL in DMSO
form :A crystalline solid
color :White to off-white
InChI :InChI=1S/C21H21N3O4/c1-3-15-5-4-6-16(11-15)24-21-17-12-19(27-8-7-25)20(28-10-9-26-2)13-18(17)22-14-23-21/h1,4-6,11-14,25H,7-10H2,2H3,(H,22,23,24)
InChIKey :KOQIAZNBAWFSQM-UHFFFAOYSA-N
SMILES :C(O)COC1C(OCCOC)=CC2C(C=1)=C(NC1=CC=CC(C#C)=C1)N=CN=2
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
OSI-420 is a metabolite of Erlotinib. Erlontinib potently inhibits EGFR autophosphorylation in cultured human head and neck tumor cells, a cell line which exhibits high levels of EGFR. Erlotinib also inhibits the proliferation of PC-9 cell lines, which contain a deletion mutation on exon 19 of the EGFR gene. A combination of Erlotinib and rapamycin produced a synergistic inhibitory effect on cell growth.Related product price
-
OSI-420-d4, Free Base (Desmethyl Erlotinib-d4)
$537-3965 -
Dacomitinib (PF299804)
$10-1703 -
CO-1686
$9-3510
