PD184352
|
- $18 - $2120
- Product name: PD184352
- CAS: 212631-79-3
- MF: C17H14ClF2IN2O2
- MW: 478.66
- EINECS:
- MDL Number:MFCD02683961
- Synonyms:PD184352;2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide;2-(2-CHLORO-4-IODOANILINO)-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE;2-[(2-CHLORO-4-IODOPHENYL) AMINO]-N-(CYCLOPROPYLME;Benzamide, 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-;Ci-1040;CI-1040, PD-184352;3,4-Difluoro-2-(2-chloro-4-iodophenylaMino)-N-cyclopropylMethoxybenzaMide
91 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 20mg
- 10mM*1mLinDMSO
- 2x5mg
- 25.00g
- 50
- 200mg
- 10.00g
- 50.00g
- 10
- 10mM(in1mLDMSO)
- 1mg
- 5mg
- 10mg
- 25mg
- 1G
- 50mg
- 100mg
- 250mg
- 10mM(in 1mL DMSO)
- Manufactureraablocks
- Product numberAA00I40C
- Product descriptionCI-1040 98%
- Packaging1mg
- Price$18
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00I40C
- Product descriptionCI-1040 98%(HPLC)
- Packaging5mg
- Price$29
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00I40C
- Product descriptionCI-1040 98%(HPLC)
- Packaging10mg
- Price$46
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00I40C
- Product descriptionCI-1040 98%(HPLC)
- Packaging25mg
- Price$77
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00I40C
- Product descriptionCI-1040 98%
- Packaging50mg
- Price$129
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00I40C
- Product descriptionCI-1040 98%(HPLC)
- Packaging100mg
- Price$178
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00I40C
- Product descriptionCI-1040 98%(HPLC)
- Packaging250mg
- Price$275
- Updated2026-05-29
- Buy
- ManufacturerACHEMBLOCK
- Product numberK12410
- Product descriptionCI-1040 98%
- Packaging100MG
- Price$150
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberK12410
- Product descriptionCI-1040 98%
- Packaging25MG
- Price$60
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberK12410
- Product descriptionCI-1040 98%
- Packaging1G
- Price$550
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0029-M001
- Product descriptionPD 184352 ≥95%(HPLC,NMR)
- Packaging1mg
- Price$20
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0029-M001
- Product descriptionPD 184,352 ≥98%(HPLC)
- Packaging1mg
- Price$20
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0029-M005
- Product descriptionPD 184,352 ≥98%(HPLC)
- Packaging5mg
- Price$60
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product numberX7396
- Product descriptionPD 184352
- Packaging5mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7396
- Product descriptionPD 184352
- Packaging50mg
- Price$324
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA832312
- Product descriptionCI-1040 98+%
- Packaging100mg
- Price$267
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00I40C | CI-1040 98% | 1mg | $18 | 2026-05-29 | Buy |
| aablocks | AA00I40C | CI-1040 98%(HPLC) | 5mg | $29 | 2026-05-29 | Buy |
| aablocks | AA00I40C | CI-1040 98%(HPLC) | 10mg | $46 | 2026-05-29 | Buy |
| aablocks | AA00I40C | CI-1040 98%(HPLC) | 25mg | $77 | 2026-05-29 | Buy |
| aablocks | AA00I40C | CI-1040 98% | 50mg | $129 | 2026-05-29 | Buy |
| aablocks | AA00I40C | CI-1040 98%(HPLC) | 100mg | $178 | 2026-05-29 | Buy |
| aablocks | AA00I40C | CI-1040 98%(HPLC) | 250mg | $275 | 2026-05-29 | Buy |
| ACHEMBLOCK | K12410 | CI-1040 98% | 100MG | $150 | 2026-05-27 | Buy |
| ACHEMBLOCK | K12410 | CI-1040 98% | 25MG | $60 | 2026-05-27 | Buy |
| ACHEMBLOCK | K12410 | CI-1040 98% | 1G | $550 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-0029-M001 | PD 184352 ≥95%(HPLC,NMR) | 1mg | $20 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-0029-M001 | PD 184,352 ≥98%(HPLC) | 1mg | $20 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0029-M005 | PD 184,352 ≥98%(HPLC) | 5mg | $60 | 2026-05-06 | Buy |
| AK Scientific | X7396 | PD 184352 | 5mg | $49 | 2021-12-16 | Buy |
| AK Scientific | X7396 | PD 184352 | 50mg | $324 | 2021-12-16 | Buy |
| Ambeed | A832312 | CI-1040 98+% | 100mg | $267 | 2021-12-16 | Buy |
Properties
Melting point :166-169°C
Density :1.747±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: ≥30mg/mL
pka :-5.58±0.50(Predicted)
form :powder
color :white to tan
InChI :1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
InChIKey :GFMMXOIFOQCCGU-UHFFFAOYSA-N
SMILES :Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F
Density :1.747±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: ≥30mg/mL
pka :-5.58±0.50(Predicted)
form :powder
color :white to tan
InChI :1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
InChIKey :GFMMXOIFOQCCGU-UHFFFAOYSA-N
SMILES :Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
The dual specific threonine/tyrosine kinase, map kinase kinase (MEK), is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. CI-1040 is a benzhydroxamate compound that potently inhibits MEK in an in vitro mitogen-activated protein kinase cascade assay with an IC50 value of 2.3 nM (Kd = 74 nM when activated with adenosine triphosphate). It can suppress phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 35 nM and demonstrates in vivo activity with oral administration in a mouse tumor model. The second-generation MEK inhibitor PD 0325901 is a structural derivative of CI-1040 that was developed for improved solubility.Related product price
-
Rapamycin
$9-6160 -
252917-06-9
$28-4401 -
SB 203580
$16-2151
