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ChemicalBook >> CAS DataBase List >> R-406

R-406

R-406 price.
  • $13 - $5180
  • Product name: R-406
  • CAS: 841290-80-0
  • MF: C22H23FN6O5
  • MW: 470.45
  • EINECS:617-533-5
  • MDL Number:MFCD09970820
  • Synonyms:R-406;6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one ;6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one;6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one;R406(free base);R-406 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one;R406 (free base), >=98%;R406 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
80 prices
Selected condition:
Brand
  • aablocks
  • ACHEMBLOCK
  • Adipogen Life Sciences
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 25mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • EvaluationSample
  • 10mM(in1mLDMSO)
  • 1unit
  • 10mM*1mLinDMSO(Solution)
  • 2x25mg
  • 250.00mg
  • 1.00g
  • 5.00g
  • 10mM*1mLinDMSO
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 100mg
  • 500MG
  • 50mg
  • 250mg
  • 5g
  • 10mM(in 1mL DMSO)
  • 1g
  • Manufactureraablocks
  • Product numberAA008GUJ
  • Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%
  • Packaging1mg
  • Price$13
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008GUJ
  • Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%
  • Packaging2mg
  • Price$16
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008GUJ
  • Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%
  • Packaging5mg
  • Price$19
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008GUJ
  • Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%
  • Packaging10mg
  • Price$23
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA008GUJ
  • Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%
  • Packaging100mg
  • Price$34
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA008GUJ
  • Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 95%
  • Packaging250mg
  • Price$40
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA008GUJ
  • Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98%
  • Packaging1g
  • Price$79
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA008GUJ
  • Product description6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 95%
  • Packaging5g
  • Price$318
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberA-624
  • Product description6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 95%
  • Packaging5G
  • Price$243
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberA-624
  • Product description6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 95%
  • Packaging1G
  • Price$72
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberA-624
  • Product description6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 95%
  • Packaging100MG
  • Price$36
  • Updated2026-05-27
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1121-M001
  • Product descriptionR406 ≥95%
  • Packaging1mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1121-M001
  • Product descriptionR406 ≥95%
  • Packaging1mg
  • Price$108
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1121-M005
  • Product descriptionR406 ≥95%
  • Packaging5mg
  • Price$178
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1121-M010
  • Product descriptionR406 ≥95%
  • Packaging10mg
  • Price$270
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1121-M050
  • Product descriptionR406 ≥95%
  • Packaging50mg
  • Price$918
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA008GUJ 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98% 1mg $13 2026-05-28 Buy
aablocks AA008GUJ 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98% 2mg $16 2026-05-28 Buy
aablocks AA008GUJ 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98% 5mg $19 2026-05-28 Buy
aablocks AA008GUJ 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98% 10mg $23 2026-05-28 Buy
aablocks AA008GUJ 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98% 100mg $34 2026-05-28 Buy
aablocks AA008GUJ 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 95% 250mg $40 2026-05-28 Buy
aablocks AA008GUJ 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 98% 1g $79 2026-05-28 Buy
aablocks AA008GUJ 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one 95% 5g $318 2026-05-28 Buy
ACHEMBLOCK A-624 6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 95% 5G $243 2026-05-27 Buy
ACHEMBLOCK A-624 6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 95% 1G $72 2026-05-27 Buy
ACHEMBLOCK A-624 6-[5-Fluoro-2-(3,4,5-trimethoxy-phenylamino)-pyrimidin-4-ylamino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one 95% 100MG $36 2026-05-27 Buy
Adipogen Life Sciences SYN-1121-M001 R406 ≥95% 1mg $108 2021-12-16 Buy
Adipogen Life Sciences SYN-1121-M001 R406 ≥95% 1mg $108 2026-05-06 Buy
Adipogen Life Sciences SYN-1121-M005 R406 ≥95% 5mg $178 2026-05-06 Buy
Adipogen Life Sciences SYN-1121-M010 R406 ≥95% 10mg $270 2026-05-06 Buy
Adipogen Life Sciences SYN-1121-M050 R406 ≥95% 50mg $918 2026-05-06 Buy

Properties

Melting point :182-184°C
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :10.63±0.40(Predicted)
color :Off-White to Light Grey
InChI :1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
InChIKey :NHHQJBCNYHBUSI-UHFFFAOYSA-N
SMILES :CC1(C(NC2=C(O1)C=CC(NC3=NC(NC4=CC(OC)=C(C(OC)=C4)OC)=NC=C3F)=N2)=O)C

Safety Information

Symbol(GHS): Health Hazard (GHS08)Skull and Crossbones (GHS06)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P281 Use personal protective equipment as required.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcεRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 μM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce immune complex-mediated inflammation. In cancers characterized by over-expression of Syk, R406 can prevent signaling downstream of Syk and induce apoptosis. R406 also inhibits Syk-dependent signaling through c-Jun N-terminal kinase in rheumatoid arthritis synoviocytes, suggesting a therapeutic intervention in this autoimmune disease.

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