Ruxolitinib
|
- $10 - $2757.4
- Product name: Ruxolitinib
- CAS: 941678-49-5
- MF: C17H18N6
- MW: 306.37
- EINECS:1312995-182-4
- MDL Number:MFCD12031592
- Synonyms:(3R)-3-(4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile;(3R)-3-cyclopentyl-3-(4-{7H-pyrrolo[2,3-d]pyriMidin-4-yl}-1H-pyrazol-1-yl)propanenitrile;INCB018424 (Ruxolitinib);Ruxolitinib(INCB-018424);1H-Pyrazole-1-propanenitrile,.beta.-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyriMidin-4-yl)-,(.beta.R)-;Ruxolitinib;Ruxolitinib INCB018424 Jakafi;Jakafi Ruxolitinib (INCB018424)
121 prices
Selected condition：
Brand
- aablocks
- AccelPharmtech
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- Tocris
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO
- 1mg
- EvaluationSample
- 50
- 100.00mg
- 200mg
- 250.00mg
- 0.5g
- 500mg
- 1.00g
- 2g
- 10mM(in1mLDMSO)
- 2.5MG
- 5mg
- 10MG
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 5g
- 10g
- 25g
- Manufactureraablocks
- Product numberAA0034XX
- Product description(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile ≥98%
- Packaging5mg
- Price$10
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0034XX
- Product description(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile ≥98%
- Packaging25mg
- Price$17
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0034XX
- Product description(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile ≥98%
- Packaging100mg
- Price$40
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0034XX
- Product description(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile ≥98%
- Packaging50mg
- Price$30
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0034XX
- Product description(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile ≥98%
- Packaging250mg
- Price$77
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0034XX
- Product description(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile ≥98%
- Packaging1g
- Price$200
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0034XX
- Product description(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile 95%
- Packaging5g
- Price$779
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0034XX
- Product description(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile 95%
- Packaging10g
- Price$1342
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0034XX
- Product description(βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile 95%
- Packaging25g
- Price$2676
- Updated2026-05-28
- Buy
- ManufacturerAccelPharmtech
- Product numberLW2807
- Product descriptionRuxolitinib 98%
- Packaging1G
- Price$1270
- Updated2021-12-16
- Buy
- ManufacturerAccelPharmtech
- Product numberLW2807
- Product descriptionRuxolitinib 98%
- Packaging1G
- Price$1270
- Updated2026-05-21
- Buy
- ManufacturerACHEMBLOCK
- Product numberG-6185
- Product descriptionRuxolitinib 98%
- Packaging5G
- Price$670
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberG-6185
- Product descriptionRuxolitinib 98%
- Packaging1G
- Price$200
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberG-6185
- Product descriptionRuxolitinib 98%
- Packaging100MG
- Price$45
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3624-M005
- Product descriptionRuxolitinib (free base) ≥98%(HPLC)
- Packaging5mg
- Price$60
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3624-M025
- Product descriptionRuxolitinib (free base) ≥98%(HPLC)
- Packaging25mg
- Price$95
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0034XX | (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile ≥98% | 5mg | $10 | 2026-05-28 | Buy |
| aablocks | AA0034XX | (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile ≥98% | 25mg | $17 | 2026-05-28 | Buy |
| aablocks | AA0034XX | (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile ≥98% | 100mg | $40 | 2026-05-28 | Buy |
| aablocks | AA0034XX | (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile ≥98% | 50mg | $30 | 2026-05-28 | Buy |
| aablocks | AA0034XX | (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile ≥98% | 250mg | $77 | 2026-05-28 | Buy |
| aablocks | AA0034XX | (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile ≥98% | 1g | $200 | 2026-05-28 | Buy |
| aablocks | AA0034XX | (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile 95% | 5g | $779 | 2026-05-28 | Buy |
| aablocks | AA0034XX | (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile 95% | 10g | $1342 | 2026-05-28 | Buy |
| aablocks | AA0034XX | (βR)-β-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile 95% | 25g | $2676 | 2026-05-28 | Buy |
| AccelPharmtech | LW2807 | Ruxolitinib 98% | 1G | $1270 | 2021-12-16 | Buy |
| AccelPharmtech | LW2807 | Ruxolitinib 98% | 1G | $1270 | 2026-05-21 | Buy |
| ACHEMBLOCK | G-6185 | Ruxolitinib 98% | 5G | $670 | 2026-05-27 | Buy |
| ACHEMBLOCK | G-6185 | Ruxolitinib 98% | 1G | $200 | 2026-05-27 | Buy |
| ACHEMBLOCK | G-6185 | Ruxolitinib 98% | 100MG | $45 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-3624-M005 | Ruxolitinib (free base) ≥98%(HPLC) | 5mg | $60 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-3624-M025 | Ruxolitinib (free base) ≥98%(HPLC) | 25mg | $95 | 2026-05-06 | Buy |
Properties
Melting point :84-89°C
Density :1.40
storage temp. :-20°
solubility :Soluble in DMSO (up to 28 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
form :White powder.
pka :11.63±0.50(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :InChI=1/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/s3
InChIKey :HFNKQEVNSGCOJV-UJHUVDBMNA-N
SMILES :[C@@H](C1CCCC1)(N1N=CC(C2N=CN=C3NC=CC=23)=C1)CC#N |&1:0,r|
CAS DataBase Reference :941678-49-5
Density :1.40
storage temp. :-20°
solubility :Soluble in DMSO (up to 28 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
form :White powder.
pka :11.63±0.50(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI :InChI=1/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/s3
InChIKey :HFNKQEVNSGCOJV-UJHUVDBMNA-N
SMILES :[C@@H](C1CCCC1)(N1N=CC(C2N=CN=C3NC=CC=23)=C1)CC#N |&1:0,r|
CAS DataBase Reference :941678-49-5
Safety Information
| Symbol(GHS): |
 
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. A JAK2 gene fusion mutation, JAK2V617F, that causes unchecked activation of various growth factors and cytokines, has been linked to myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Ruxolitinib is a potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively and is relatively less selective for JAK3 (IC50 = 322 nM). It can block interleukin-6 (IL-6) signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM). In primary cultures, ruxolitinib preferentially suppresses erythroid progenitor colony formation from JAK2V617F+ polycythemia vera patients (IC50 = 67 nM) versus healthy donors (IC50 > 400 nM). In a mouse model of JAK2V617F+ MPN, 90 mg/kg ruxolitinib reduced splenomegaly, decreased circulating levels of IL-6 and TNF-α, eliminated neoplastic cells, and prolonged survival of the treated animals.More related product prices
871700-17-3 Dasatinib MK-2206 2HCl Bortezomib Ibrutinib Gefitinib Abiraterone Lenalidomide Ponatinib Calcium dobesilate Posaconazole 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol DL-Malic acid 283173-50-2 Ruxolitinib phosphate Y27632 (hydrochloride) PF-01367338Related product price
-
871700-17-3
$28-4391.1 -
Dasatinib
$9-4498.73 -
MK-2206 2HCl
$10-5132
Suppliers and manufacturers
Senova Technology Co. Ltd.
Trametinib
CAS:941678-49-5
shandong perfect biotechnology co.ltd
Ruxolitinib
CAS:941678-49-5
Hangzhou ICH Biofarm Co., Ltd
Ruxolitinib
CAS:941678-49-5
Henan Fengda Chemical Co., Ltd
Ruxolitinib
CAS:941678-49-5
airuikechemical co., ltd.
Zhengzhou Anhuida Chemical Co., Ltd
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD
Suzhou ARTK Medchem Co., Ltd.
Ruxolitinib
CAS:941678-49-5