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ChemicalBook >> CAS DataBase List >> SGC0946

SGC0946

$22 - $3200
Product name: SGC0946
CAS: 1561178-17-3
MF: C28H40BrN7O4
MW: 618.57
EINECS:808-588-8
MDL Number:MFCD26523136
Synonyms:5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine;1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahy;SGC0946;1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea;5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-Pyrrolo[2,3-;1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5--bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydro-xytetrahydrofuran-2-yl]methyl](isopropyl)amino]pro-pyl]-3-[4-(2,2-dimethylethyl)phenyl]urea;7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-;SGC0946 USP/EP/BP

Price57 Properties Safety Information Description

57 prices

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Brand

aablocks
ACHEMBLOCK
AK Scientific
Ambeed
ApexBio Technology
Apolloscientific
Arctom
Cayman Chemical
ChemScene
DC Chemicals
Medical Isotopes, Inc.
Sigma-Aldrich
Tocris
TRC
Usbiological

Package

10mM*1mLinDMSO(Solid+Solvent)
1mg
2mg
5mg
10mg
2
25mg
50mg
10mM*1mLinDMSO(Solution)
100MG
250mg
1g

Manufactureraablocks
Product numberAA001OG0
Product description5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 99%
Packaging1mg
Price$22
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001OG0
Product description5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 99%
Packaging5mg
Price$46
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA001OG0
Product description5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 99%
Packaging10mg
Price$81
Updated2026-05-28
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Manufactureraablocks
Product numberAA001OG0
Product description5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 99
Packaging25mg
Price$167
Updated2026-05-28
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Manufactureraablocks
Product numberAA001OG0
Product description5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 99%
Packaging50mg
Price$225
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberU102945
Product descriptionSGC0946 98.00%
Packaging25MG
Price$220
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberU102945
Product descriptionSGC0946 98.00%
Packaging100MG
Price$715
Updated2026-05-27
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ManufacturerAK Scientific
Product number2714AH
Product description5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Packaging50mg
Price$718
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number2714AH
Product description5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Packaging25mg
Price$446
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number2714AH
Product description5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Packaging5mg
Price$143
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number2714AH
Product description5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Packaging2mg
Price$116
Updated2021-12-16
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ManufacturerAmbeed
Product numberA702574
Product description1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%
Packaging5mg
Price$77
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA702574
Product description1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%
Packaging1mg
Price$35
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA702574
Product description1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%
Packaging10mg
Price$115
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA702574
Product description1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%
Packaging50mg
Price$287
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA702574
Product description1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%
Packaging25mg
Price$194
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA001OG0	5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 99%	1mg	$22	2026-05-28	Buy
aablocks	AA001OG0	5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 99%	5mg	$46	2026-05-28	Buy
aablocks	AA001OG0	5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 99%	10mg	$81	2026-05-28	Buy
aablocks	AA001OG0	5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 99	25mg	$167	2026-05-28	Buy
aablocks	AA001OG0	5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 99%	50mg	$225	2026-05-28	Buy
ACHEMBLOCK	U102945	SGC0946 98.00%	25MG	$220	2026-05-27	Buy
ACHEMBLOCK	U102945	SGC0946 98.00%	100MG	$715	2026-05-27	Buy
AK Scientific	2714AH	5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine	50mg	$718	2021-12-16	Buy
AK Scientific	2714AH	5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine	25mg	$446	2021-12-16	Buy
AK Scientific	2714AH	5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine	5mg	$143	2021-12-16	Buy
AK Scientific	2714AH	5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-7H-pyrrolo[2,3-d]pyrimidin-4-amine	2mg	$116	2021-12-16	Buy
Ambeed	A702574	1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%	5mg	$77	2021-12-16	Buy
Ambeed	A702574	1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%	1mg	$35	2021-12-16	Buy
Ambeed	A702574	1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%	10mg	$115	2021-12-16	Buy
Ambeed	A702574	1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%	50mg	$287	2021-12-16	Buy
Ambeed	A702574	1-(3-((((2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 98+%	25mg	$194	2021-12-16	Buy

Next Last

Properties

Melting point :125-126o C
Boiling point :771.5±60.0 °C(Predicted)
Density :1.48±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
pka :12.39±0.70(Predicted)
form :powder
color :white to beige
InChIKey :IQCKJUKAQJINMK-AZXARCNZNA-N
SMILES :N(CCCN(C[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=C(Br)C3=C(N)N=CN=C32)O1)C(C)C)C(NC1=CC=C(C(C)(C)C)C=C1)=O |&1:6,7,9,11,r|

Safety Information

Symbol(GHS):

Signal word:

Danger

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H301	Toxic if swalloed	Acute toxicity,oral	Category 3	Danger		P264, P270, P301+P310, P321, P330,P405, P501

Precautionary statements:

P301+P310

IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

DOT1L is a protein methyltransferase (PMT). It is the only enzyme known to methylate histone 3 at lysine 79 (H3K79), where it catalyzes mono-, di-, and trimethylation. Proper DOT1L function is necessary for transcriptional activation of many genes, DNA damage repair, and cell cycle regulation. SGC0946 is a potent inhibitor of DOT1L (IC50 = 0.3 nM) developed by the Structural Genomics Consortium (SGC). It is over 100-fold selective over other PMTs. It is active in cells, reducing H3K79 dimethylation in A431 and MCF10A cells (IC50s = 2.6 and 8.8 nM, respectively). SGC0946 is a brominated analog of EPZ004777, an S-adenosylmethionine-competitive inhibitor of DOT1L. Both SGC0946 and EPZ004777 selectively kill mixed lineage leukemia (MLL) cells, in which DOT1L is aberrantly localized via interaction with an oncogenic MLL fusion protein.

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SGC0946

Properties

Safety Information

Description

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